Use of HOMA-IR in hepatitis C

Eslam, Mohammed; Kawaguchi, Takumi; Campo, J.A. Del; Sata, Michio; Khattab, Mahmoud A.; Romero–Gómez, Manuel

doi:10.1111/j.1365-2893.2011.01474.x

Cited by 38 publications

(30 citation statements)

References 108 publications

(169 reference statements)

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“…Addi tionally, DM has been shown to affect the prognosis of HCC after curative therapies [14] . Furthermore, DM type 2 can lead to HCC caused by carcinogenic effects on the liver and other tissues from insulinlike growth factor1 (IGF1) due to hyperinsulinaemia and insulinresistance ( Figure 1) [15,16] . The risk for HCC was particularly higher in diabetic patients treated with insulin [17] .…”

Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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The prevalence of hepatocellular carcinoma (HCC) has progressively increased in recent years and is now the fifth and the second most common cancer in the World and in Egypt, respectively. Much work has focused in the development of assays for detecting hepatic carcinogensis before the observance of hepatic focal lesions. Particular attention has been directed towards HCC-specific biomarkers for use in the early diagnosis of HCC and in the confirmation of radiological studies. Although a number of biomarkers have been identified, none have been considered reliable indicators of early HCC lesions. This review presents a few of the most relevant HCC biomarkers and suggests improvements to the accuracy of diagnostic assays through their combined use. Furthermore, we present an algorithm for the biomarker-based diagnosis of HCC and highlight its important role in the early prediction of HCC. Core tip: Alpha-fetoprotein (AFP) has been widely used as a reference biomarker to validate the diagnosis of hepatocellular carcinoma (HCC). However, normal physiological-levels of AFP are observed in approximately one third of HCC cases. Furthermore, a number of HCC positive patients have AFP levels less than the threshold value of 400 ng/mL. These factors make an AFP-based diagnosis of HCC far from reliable. However, high diagnostic accuracy indices have been reported when AFP is combined with other biomarkers such as midkine, golgi protein 73, des-γ-carboxyprothrombin, glypican-3, and gamma-glutamyl transferase.Khattab M, Fouad M, Ahmed E. Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma. World J Hepatol 2015; 7(23): 24742481 Available from:

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Section: Pathogenesis and Risk Factorsmentioning

confidence: 99%

Role of biomarkers in the prediction and diagnosis of hepatocellular carcinoma

Khattab

Fouad

Ahmed

2015

WJH

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“…Many studies have described the interaction of HIV, HCV infection, and antiretroviral therapy to increase the risk of insulin resistance and T2DM, 48,49 although the mechanisms are not completely understood. Moreover, there is growing evidence that genetic background may contribute to differences between individuals in complex diseases.…”

Section: Discussionmentioning

confidence: 99%

rs7903146 Polymorphism atTranscription Factor 7 Like 2Gene Is Associated with Total Cholesterol and Lipoprotein Profile in HIV/Hepatitis C Virus-Coinfected Patients

Pineda‐Tenor

Berenguer

Jiménez-Sousa

et al. 2015

AIDS Research and Human Retroviruses

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Transcription factor 7 like 2 (TCF7L2) rs7903146 polymorphism has been associated with metabolic disturbance and cardiovascular disease. The aim of this study was to analyze the association between TCF7L2 rs7903146 polymorphism and potential disturbances on the lipid profile in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients. We performed a cross-sectional study on 263 HIV/HVC-coinfected patients. TCF7L2 polymorphism was genotyped by GoldenGate assay. The analysis was performed by linear and logistic regression under a dominant model of inheritance. The variables analyzed were total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), non-HDL-C, and triglycerides. Patients harboring the rs7903146 TT/TC genotype showed a diminished concentration of TC (p=0.003), LDL-C (p=0.004), HDL-C (p=0.012), and non-HDL-C (p=0.013), a lower percentage of TC≥200 mg/dl (p=0.038), and a higher percentage of HDL≤40 mg/dl (p=0.023). In addition, we observed that rs7903146 was differently related to fasting serum lipid levels according to the HCV-genotype (HCV-GT). With regard to HCV-GT1 patients, the rs7903146 TT/TC genotype was associated with lower levels of HDL-C [adjusted arithmetic mean ratio (aAMR)=0.91; p=0.049] and an elevated percentage of patients with HDL-C≤40 mg/dl [adjusted odds ratio (aOR)=3.26; p=0.003]. For HCV-GT3 patients, the rs7903146 TT/TC genotype was associated with lower serum values of TC (aAMR=0.81; p=0.037), LDL-C (aAMR=0.67; p=0.001), and non-HDL-C (aAMR=0.75; p=0.002) and a reduced percentage of TC≥200 mg/dl (aOR=0.089; p=0.037). In conclusion, the TCF7L2 rs7903146 TT/TC genotype was associated with lower levels of TC, LDL, and HDL in HCV-GT3 patients, and lower levels of HDL-C in HCV-GT1 patients, suggesting a role in cardiovascular disease and a potential use as a biomarker in HIV/HCV-coinfected patients.

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“…The HOMA-IR is the most commonly used model for assessing insulin resistance in CHC [18], but there is great variability in the threshold HOMA-IR levels (from 1.5 to >4) to define insulin resistance in CHC [18]. In this article, we evaluated the thresholds for HOMA-IR at least 2.0, 2.5, 3.0 and 3.8.…”

Section: Biochemical Datamentioning

confidence: 97%