Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Swider, Pascal; Conroy, Mary Carol; Pedrono, Annaig; Ambard, Dominique; Mantell, Susan C.; Søballe, Kjeld; Bechtold, Joan E.

doi:10.1016/j.jbiomech.2006.10.002

Cited by 38 publications

(21 citation statements)

References 32 publications

(27 reference statements)

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“…The microCT technique has also been used to monitor three-dimensional mineralization over time in a perfusion bioreactor (Porter et al 2007). High-resolution magnetic resonance imaging (MRI) could also be useful to determine axial fluid velocity within the pores of a scaffold (Swider et al 2007).…”

Section: Scaffold Characterization Through Computed Tomography Imagesmentioning

confidence: 99%

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Lacroix

Planell

Prendergast

2009

Phil. Trans. R. Soc. A.

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Scaffold biomaterials for tissue engineering can be produced in many different ways depending on the applications and the materials used. Most research into new biomaterials is based on an experimental trial-and-error approach that limits the possibility of making many variations to a single material and studying its interaction with its surroundings. Instead, computer simulation applied to tissue engineering can offer a more exhaustive approach to test and screen out biomaterials. In this paper, a review of the current approach in biomaterials designed through computer-aided design (CAD) and through finite-element modelling is given. First we review the approach used in tissue engineering in the development of scaffolds and the interactions existing between biomaterials, cells and mechanical stimuli. Then, scaffold fabrication through CAD is presented and characterization of existing scaffolds through computed images is reviewed. Several case studies of finite-element studies in tissue engineering show the usefulness of computer simulations in determining the mechanical environment of cells when seeded into a scaffold and the proper design of the geometry and stiffness of the scaffold. This creates a need for more advanced studies that include aspects of mechanobiology in tissue engineering in order to be able to predict over time the growth and differentiation of tissues within scaffolds. Finally, current perspectives indicate that more efforts need to be put into the development of such advanced studies, with the removal of technical limitations such as computer power and the inclusion of more accurate biological and genetic processes into the developed algorithms.

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Section: Scaffold Characterization Through Computed Tomography Imagesmentioning

confidence: 99%

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Lacroix

Planell

Prendergast

2009

Phil. Trans. R. Soc. A.

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“…18,19 It is therefore capable of influencing tissue formation, by the diffusion of nutrients, waste products and cytokines through the scaffold. 3,20,21 Permeability is determined by various other parameters including porosity and the arrangement of pore struts. 22 It can also be affected by scaffold anisotropy.…”

Section: The Unique Case Of Tissue Engineering Scaffolds Specific Reqmentioning

confidence: 99%

“…47,50 It is powerful in that fluid velocity data may also be obtained to gain an impression of the effect of the scaffold architecture on fluid flow. 21 The disadvantage is that the resolution of MRI is low, limited to ,50 um. 47 Micro-CT, with available resolutions of 1 mm and lower, has therefore emerged as a key technique for analysis of tissue engineering scaffolds.…”

Section: Existing Characterisation Techniquesmentioning

confidence: 99%

Quantitative architectural description of tissue engineering scaffolds

Ashworth

Best

Cameron

2014

Materials Technology

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Arguably one of the most specialised subtopics in porous materials research is that of tissue engineering scaffolds. The porous architecture of these scaffolds is a key variable in determining biological response. However, techniques for characterising these materials tend to vary widely in the literature. There is a need for a set of transferable and effective methods for architectural characterisation. In this review, four key areas of importance are addressed. First, the definition and interpretation of pore size are considered in relation to fluid transport properties, by analogy with filtration research. Second, the definition of interconnectivity is discussed using insight obtained from cement and concrete research. Third, the issue of data scalability is addressed by consideration of percolation theory, as implemented for the study of geological materials. Finally, emerging techniques such as confocal and multiphoton microscopy are discussed. These methods allow the three-dimensional observation of pore strut arrangement, as well holding great potential for understanding changes in pore architecture under dynamic conditions.

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“…A complete description of the velocity field in slices with phase contrast (PC) method was shown. The velocity field is influenced by the size of MR image pixel and pore size, and the pixel size was chosen to be lower than the pore size (Swider et al, 2007). Two dimensional and three dimensional liquid distribution images in catalyst beds under steady state trickle flow condition were measured (Nguyen et al, 2005;Gladden et al, 2005;Anadon et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

An experimental study on CO2/water displacement in porous media using high-resolution Magnetic Resonance Imaging

Song

Jiang

Liu

et al. 2012

International Journal of Greenhouse Gas Control

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Use of high-resolution MRI for investigation of fluid flow and global permeability in a material with interconnected porosity

Cited by 38 publications

References 32 publications

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Computer-aided design and finite-element modelling of biomaterial scaffolds for bone tissue engineering

Quantitative architectural description of tissue engineering scaffolds

An experimental study on CO2/water displacement in porous media using high-resolution Magnetic Resonance Imaging

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