Use of high-resolution mass spectrometry for veterinary drug multi-residue analysis

Critical Evaluation of Two Qualitative Analytical Approaches for Multiclass Determination of Veterinary Drugs in Bovine Muscle Using UHPLC-Q-Orbitrap: The Wind of Change in Brazilian Monitoring

“…Based on analytical performance, Jongedijk et al [ 27 ] described the significant growth of the application of the technique for the analysis of residues of veterinary drugs and hormones in recent years, especially in the screening of multiple residues. This is a field that already has a high degree of confidence in its applicability in several European laboratories.…”

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

“…GCs have also been widely used in animal husbandry due to their anti-inflammatory, anti-shock, and anti-allergic properties. [12][13][14] Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism. [15][16][17][18] Hence, in order to ensure the human health, the European Union has established the maximum residue limits (MRLs) for GCs in animal tissues and foodstuffs.…”

“…Over the past few decades, the synthetic GCs commonly used in clinical practice included dexamethasone, betamethasone, prednisolone, and methylprednisolone, [9–11] as shown in Figure 1. GCs have also been widely used in animal husbandry due to their anti‐inflammatory, anti‐shock, and anti‐allergic properties [12–14] . Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism [15–18] .…”

Multiclass method for antimicrobial residue analysis in milk using liquid chromatography-quadrupole-time of flight-mass spectrometry (LC-qTOF-MS): validation and application for real samples with ciprofloxacin

“…Therefore, the improvement of analytical instrumentation as provided by tandem mass spectrometry has allowed the development of more sensitive and selective methods, while allowing analysis of multiple groups of antimicrobials in a single run. Thus, mass analyzers such as Time-of-Flight (ToF) and Orbitrap make it possible to perform high-resolution full-scan mass spectrum acquisition, acquiring high-precision mass measurements (< 1-3 mg.kg − 1 ) at resolutions greater than 20,000 and, in most cases, with sensitivity and selectivity comparable to triple quadrupoles in MRM mode (Geib et al 2016;Jongedijk et al 2023).…”