Use of high pressure techniques to produce Mangifera indica L. leaf extracts enriched in potent antioxidant phenolic compounds

Férnandez-Ponce, M.T.; Casas, Lourdes; Mantell, Casimiro; Ossa, Enrique Martínez de la

doi:10.1016/j.ifset.2015.04.006

Cited by 78 publications

(57 citation statements)

References 31 publications

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“…This behavior was observed for phenolic compounds from Euterpe edulis peels and pulp near the seeds by Garcia-Mendonza et al (Garcia-Mendoza et al, 2017). According to Fernández-Ponce et al (2015) and Santos et al (2012), others fruits extracts presented the same behaviors for temperature action. The interaction of ratio of microwave power (X 1 ) and exposition time (X 2 ) are presented in Figure 1-A3.…”

Section: Interactions Of the Studied Factorssupporting

confidence: 55%

Natural Antioxidant Activity and Compounds Content from Wastes of Euterpe edulis Berries

Frasão¹,

Costa²,

Rodrigues³

et al. 2017

JAS

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The Euterpe edulis (Juçara) is native to Brazil, which berries and wastes present high antioxidant content. Therefore, in this study, microwave-assisted extraction (MAE) was investigated for antioxidant compounds extraction from E. edulis waste and maximized antioxidant activities using response surface methodology coupled with a central composite design. Three factors were observed: microwave power (400/500/600 W), exposition time (30/60/90 sec) and ethanol concentration solvent (40/60/80%). The extracts were characterized by determination of total phenolic (TPC), flavonoids (TFC), monomeric anthocyanins (TAC), tannins content (TTC), and in vitro antioxidant assay (AA%). The yield of TPC, TFC, TAC, and TTC varied at 595.43-2171.34 mg GAE·100 g DM , respectively. The optimal MAE parameters for TPC was microwave power 668.18 W, exposition time 110.45 s and aqueous ethanol concentration 93.64%, for TFC same parameters observed; though for TAC the different parameters were 532.28 W, and for TTC 9.55 s. However, for antioxidant activity, the parameters were 668.18 W, 110.45 s time and 64.41% of aqueous ethanol solvent. Therefore, this methodology was successfully applied for optimal extraction of total phenolics, flavonoids, monomeric anthocyanins and tannins from juçara waste and obtain optimal antioxidant activity.

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Section: Interactions Of the Studied Factorssupporting

confidence: 55%

Natural Antioxidant Activity and Compounds Content from Wastes of Euterpe edulis Berries

Frasão¹,

Costa²,

Rodrigues³

et al. 2017

JAS

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show abstract

“…C57BL/KsJ heterozygous db/1 mice were purchased from Harlan Laboratories (Boxmeer, The Netherlands). Wild type, db/db and db/1 mice were generated from crosses between heterozygous db/1 mice and all mice were genotyped as previously described (13). As heterozygous (db/1) mice do not show specific phenotype at central or peripheral level (26,38), wild type and db/1 mice were included in the control group.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

et al. 2016

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Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. AD patients are in a tremendous need of new therapeutic options because of the limited success of available treatments. Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities. The role of MGF in central complications associated with T2D, after long-term treatment of db/db mice with MGF was analyzed. Metabolic parameters (body weight, glucose and insulin levels) as well as central complications including brain atrophy, inflammatory processes, spontaneous bleeding, tau phosphorylation and cognitive function in db/db mice treated with MGF for 22 weeks were assessed. MGF limits body weight gain in obese db/db mice. Insulin and C-peptide levels, indicative of pancreatic function, were longer maintained in MGF-treated animals. MGF reduced central inflammation by lowering microglia burden, both in the cortex and the hippocampus. Likewise, central spontaneous bleeding was significantly reduced in db/db mice. Cortical and hippocampal atrophy was reduced in db/db mice and tau hyperphosphorylation was lower after MGF treatment, resulting in partial recovery of learning and memory disabilities. Altogether, the data suggested that MGF treatment may provide a useful tool to target different aspects of AD and VaD pathology, and could lead to more effective clinical therapies for the prevention of metabolic related central complications associated with AD and VaD.

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“…In plants, bioactive compounds exist enclosed in insoluble structures, such as cell vacuoles, which are not accessible to solvents. The Th use of heat to enhance mass transfer and reduce the extraction time can have deleterious eff ects, since high temperature can degrade thermolabile ff ff compounds [140,141]. Besides, the use of solvent mixtures containing acetone or methanol, pure or combined with water or an acid, is not in accordance with the green chemistry concept [142].…”

Section: Conventional Methodsmentioning

confidence: 99%

“…Furthermore, the addition of high concentrations of CO 2 to pressurized liquid solvents enhances the kinetic desorption of analytes, inactivates unwanted enzymes that may destroy bioactive compounds, minimizes the use of liquid solvents, and reduces undesired concentration steps. Unlike MAE, PLE is not limited to solvents that can absorb microwaves [141]. Additionally, for extraction of polar compounds, PLE is considered as a potential alternative to supercritical fluid extraction (SFE).…”

Section: High-voltage Electrical Dischargesmentioning

confidence: 99%

“…Additionally, for extraction of polar compounds, PLE is considered as a potential alternative to supercritical fluid extraction (SFE). Recent studies have evalufl ated the suitability of this technology for the extraction of phenolics from mango (Mangifera indica L.) leaves [141] and roots of Scutellaria pinnatifida fi A. Hamilt. ssp.…”

Section: High-voltage Electrical Dischargesmentioning

confidence: 99%

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Determination of Antioxidant Compounds in Foodstuff

et al. 2016

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Use of high pressure techniques to produce Mangifera indica L. leaf extracts enriched in potent antioxidant phenolic compounds

Cited by 78 publications

References 31 publications

Natural Antioxidant Activity and Compounds Content from Wastes of Euterpe edulis Berries

Natural Antioxidant Activity and Compounds Content from Wastes of Euterpe edulis Berries

Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model

Determination of Antioxidant Compounds in Foodstuff

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