Use of High-density SNP analyses to develop a long-term strategy for conventional populations to prevent loss of diversity - review

Moravčíková, Nina; Kasarda, Radovan

doi:10.15414/afz.2020.23.04.236-240

Cited by 2 publications

(2 citation statements)

References 13 publications

(13 reference statements)

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“…The iHS method was also utilised in an approach that combines outcomes of different selection signature methods in dairy and beef cattle breeds (Utsunomiya et al, 2013, Kasarda et al, 2015. The detection of differences in LD variability was used to detect selection signatures between beef cattle breeds in Moravčíková et al (2019). The advantage of the LD based methods is the possibility to identify the age of each segment, thus the age of the selection signature, based on the length of the LD segment (Otto, 2000).…”

Section: Linkage Disequilibriummentioning

confidence: 99%

Linkage disequilibrium, genomic inbreeding and effective populations size to unravel population history

Mészárosová

Mészáros

Moravčíková

et al. 2021

Acta fytotechn zootechn

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Licensed under a Creative Commons Attribution 4.0 International LicenseThe use of single nucleotide polymorphism (SNP) data had become commonplace in animal breeding activities and management of livestock populations. The cost-effective genotyping allowed us to assess entire populations and learn about their history on the genomic level. This paper reviews several approaches that are commonly used in the context of genomic diversity in livestock, such as the linkage disequilibrium (LD) and assessment of autozygosity via runs of homozygosity (ROH). Both methods, however, are being used to assess the impact of natural or artificial selection on the livestock genome. Apart from these selection signatures, both the LD and ROH are used to assess the effective population size (Ne), which likewise, serves as a diversity management tool and describes the historical events in populations.

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Section: Linkage Disequilibriummentioning

confidence: 99%

Linkage disequilibrium, genomic inbreeding and effective populations size to unravel population history

Mészárosová

Mészáros

Moravčíková

et al. 2021

Acta fytotechn zootechn

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“…Therefore, the identification and evaluation of genomic regions that control congenital defects was a breakthrough for the breeding programs (Sevillano et al, 2015). Besides, the detailed knowledge of the genome using single nucleotide polymorphism (SNP) markers can be usefully applied to manage the diversity of conventional populations (Moravčíková and Kasarda, 2020).…”

Section: Introductionmentioning

confidence: 99%

Candidate genes for congenital malformations in pigs

Krupová

2021

Acta fytotechn zootechn

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Licensed under a Creative Commons Attribution 4.0 International License Congenital malformations occur in numerous pig breeding programs. Clinical symptoms, etiopathogenesis and candidate genes of the most critical congenital malformations in pigs were briefly overviewed in the study. Based on the recent literature, identifying and evaluating the genomic regions associated with defects, such as splay legs syndrome, hernias, cryptorchidism, atresia ani, kyphosis, intersexuality, and malignant melanoma, can enhance the selection response. As promising genes were published e.g. NREP, FBXO32, and HOMER1 for splay leg syndrome, SRC, OSM, COL family, and CGRP for hernias, GNRHR, GATA2, and RLF for cryptorchidism, and GLI2 for atresia ani. Potential candidate genes associated with defects were mainly detected in literature by the genome-wide association approach. Reviewing the studies and following the suggestions in some of papers it is indicated the necessity for molecular and more comprehensive evaluation in terms of the sample standardisation and accurate phenotyping of a broad spectrum of populations and breeds. Moreover, knowledge transmission among all livestock species and humans is recommended in literature to better understand malformation biology.

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Use of High-density SNP analyses to develop a long-term strategy for conventional populations to prevent loss of diversity - review

Cited by 2 publications

References 13 publications

Linkage disequilibrium, genomic inbreeding and effective populations size to unravel population history

Linkage disequilibrium, genomic inbreeding and effective populations size to unravel population history

Candidate genes for congenital malformations in pigs

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