Use of helminth therapy for management of ulcerative colitis and Crohn's disease: a systematic review

Shields, Victoria Emma; Cooper, Jan

doi:10.1017/s0031182021001670

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…49 Helminthic therapy has been investigated as a treatment for relapsing remitting multiple sclerosis, Crohn's diseases, allergies and asthma. 50 The mechanism of how the helminths modulate the immune response, is unknown. Helminth's relationship to humans as hosts should be classified as mutualistic or symbiotic.…”

Section: Recent Approach In Immunotherapy 921 Allergen Immunotherapymentioning

confidence: 99%

Immunotherapeutics: Advancing precision medicine in cancer treatment

Savan,

Vaghela,

Zalavadiya

et al. 2024

IJCAAP

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Immunotherapy, also known as biologic therapy or biotherapy, is a medical treatment that utilizes the immune system to combat diseases, including cancer. Over the past few decades, immunotherapy has emerged as an integral part of cancer treatment, with various approaches being explored. This article provides an overview of immunotherapy, its mechanisms of action, and the different types of immunomodulators involved. Activation immunotherapies aim to enhance the immune response, such as cancer vaccines and cellular therapies, while suppression immunotherapies work to reduce or suppress immune activity. The article also discusses the different types of immunotherapies, including cell-based immunotherapies, immunomodulators, vaccines, antibody-based targeted therapies, and oncolytic viruses. Additionally, it highlights the characteristics of an ideal immunomodulator and the limitations associated with these therapies. Monoclonal antibodies, both naked and conjugated, are explored as a specific type of immunotherapy, with examples of their use in treating various cancers. Furthermore, the article touches upon the classification and uses of immunosuppressive agents, particularly in organ transplantation, along with their adverse effects. Overall, this article provides a comprehensive overview of immunotherapy and its diverse applications in disease treatment.

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Section: Recent Approach In Immunotherapy 921 Allergen Immunotherapymentioning

confidence: 99%

Immunotherapeutics: Advancing precision medicine in cancer treatment

Savan,

Vaghela,

Zalavadiya

et al. 2024

IJCAAP

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show abstract

“…Most of the studies on the efficacy of helminth therapy in IBD are restricted to animal models. In a recent meta-analysis, Shields and Cooper 106 concluded that it is difficult to reach any conclusion regarding the efficacy of helminth therapy. Nevertheless, helminth therapy is safe and tolerable.…”

Section: Helminths In Ibd Therapeuticsmentioning

confidence: 99%

Helminths in alternative therapeutics of inflammatory bowel disease

Pandey,

Tang,

Wong

et al. 2024

Intest Res

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anatomical distribution of inflammatory lesions. 5 Traditional IBD treatment includes immunosuppressants, corticosteroids, and aminosalicylates. The traditional treatment is now supplemented with biological therapies, which include anti-tumor necrosis factor (TNF), 6,7 anti-integrins, 8-10 anti-interleukins (ILs), [11][12][13][14][15][16] and Janus kinase (JAK) inhibitors. [17][18][19][20] Nearly 50% of patients do not respond or respond slowly to traditional and biological therapies, 21 which necessitates the continued development of new therapeutic options for IBD treatment.Researchers have been exploring the potential of helminths in various autoimmune disorders, including IBD. 22 Intestinal helminthic infections are common in developing countries with high population densities and poor sanitation. Coincidentally, these are also the regions of lower IBD prevalence. Autoimmune and inflammatory diseases are common in developed countries, though incidences of such diseases are also rising in developing countries. According to the "hygiene hypothesis, "

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“…Consequently, parasites and their products are being tested as treatments for autoimmune diseases [ 5 ]. Clinical studies on patients with inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease have shown that nematode infection can reduce inflammation of the intestine and colon [ 6 , 7 ]. Similarly, in patients suffering from multiple sclerosis, a positive outcome of helminth therapy has been observed [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation

Maruszewska-Cheruiyot

Krawczak-Wójcik

Michniowska

et al. 2023

Life

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Accumulating data suggest an important role of growth factors in autoimmune diseases and parasitic nematode infections. Nematodes are used in clinical studies of autoimmune diseases and parasite-derived molecules are widely studied for their therapeutic potential in various types of disorders. However, the effect of nematode infection on growth factors in autoimmune disorders has not been studied. The objective of this study was to evaluate the influence of infection with the intestinal nematode Heligmosomoides polygyrus in murine autoimmune models on the production of growth factors. Here, the level of a variety of growth factors related mainly to angiogenesis was evaluated by protein array in the intestinal mucosa of C57BL/6 dextran sodium sulfate-induced colitic mice and in cerebral spinal fluid of experimental autoimmune encephalomyelitis (EAE) mice infected with nematodes. In addition, vessel formation was evaluated in the brains of EAE mice infected with H. polygyrus. A significant influence of nematode infection on the level of angiogenic factors was observed. Parasitic infection of colitic mice resulted in upregulation of mucosal AREG, EGF, FGF-2, and IGFBP-3 in the intestine of the host and better adaptation (infectivity). In EAE mice, infection increased the level of FGF-2 and FGF-7 in CSF. In addition, remodeling of brain vessels was observed, with a higher density of long vessels. Nematode-derived factors are promising tools to fight autoimmune diseases and to study angiogenesis.

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Use of helminth therapy for management of ulcerative colitis and Crohn's disease: a systematic review

Cited by 8 publications

References 48 publications

Immunotherapeutics: Advancing precision medicine in cancer treatment

Immunotherapeutics: Advancing precision medicine in cancer treatment

Helminths in alternative therapeutics of inflammatory bowel disease

Nematode-Induced Growth Factors Related to Angiogenesis in Autoimmune Disease Attenuation

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