Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers

Yamamoto, Shohei; Tanaka, Akihito; Ohmagari, Norio; Yamaguchi, Koushi; Ishitsuka, Kazue; Morisaki, Naho; Kojima, Masayo; Nishikimi, Akihiko; Tokuda, Harukuni; Inoue, Manami; Tanaka, Shiori; Umezawa, Jun; Okubo, Ryo; Nishimura, Kunihiro; Konishi, Maki; Miyo, Kengo; Mizoue, Tetsuya

doi:10.1016/j.ypmed.2022.107123

Cited by 20 publications

(16 citation statements)

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“…In fact, the consumption of alcoholic beverages can generally affect the immune response. Actually, there is strong evidence that chronic alcohol abuse is associated with increased immunosuppression and susceptibility to both bacterial and viral infections [ 50 ]. Conversely, moderate alcohol consumption exerts positive effects, which has been hypothesized to enhance vaccine response [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine

et al. 2023

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The COVID-19 pandemic has hugely impacted many different aspects of human health, and vaccination is one of the most effective weapons to manage it. However, many different factors, such as age, gender, comorbidities and lifestyles, play a role in the response to infections and vaccines. We carried out this study to evaluate the potential role played by some individual factors in the production of anti-COVID-19 antibodies in the light of personalized and future vaccinology. We conducted an observational study consisting of a retrospective phase, exploiting previous data about anti-COVID-19 antibody responses, with a prospective phase to investigate individual variables through the use of a questionnaire. The antibody response after the COVID-19 vaccination was inversely related to old age, increased BMI and the number of smoking years, while a positive correlation was found with moderate alcohol consumption and especially with circulating levels of vitamin D, as clearly shown by the multivariate regression analysis. Our study showed that a number of variables are involved in the COVID-19 vaccine antibody response. These findings are very important and can be considered in the light of a future and personalized vaccinology.

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Section: Discussionmentioning

confidence: 99%

Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine

et al. 2023

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“…Studies among 2-dose recipients showed that anti-SARS-CoV-2 spike antibody titers waned faster in older age [4] and female sex [3] and slower in those with a history of COVID-19 [5], but no such investigation has been done for 3-dose. It remains elusive for both doses whether the waning speed of antibody differs depending on obesity [6,7], comorbid conditions [7,8], immunosuppression [7,8], or behavioral factors (smoking and alcohol drinking [9][10][11]), which have been linked to lower immune response to COVID-19 vaccine.…”

Section: Introductionmentioning

confidence: 99%

Durability and determinants of anti-SARS-CoV-2 spike antibodies following the second and third doses of mRNA COVID-19 vaccine

Yamamoto

Oshiro

Inamura

et al. 2022

Preprint

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Background Epidemiological data regarding differences in durability and its determinants of humoral immunity following 2– and 3–dose COVID–19 vaccination are scarce. Methods We repeatedly assessed the anti–spike IgG antibody titers of 2– and 3–dose mRNA vaccine recipients among the staff of a medical and research center in Tokyo. Linear mixed models were used to estimate trajectories of antibody titers from 14 to 180 days after the last immune–conferred event (vaccination or infection) and compare antibody waning rates across prior infection and vaccination status, and across background factors in infection–naive participants. Results A total of 6901 measurements from 2964 participants (median age, 35 years; 30% male) were analyzed. Antibody waning rate (per 30 days [95% CI]) was slower after 3–dose (25% [23 – 26]) than 2–dose (36% [35 – 37]). Participants with hybrid immunity (vaccination and infection) had further slower waning rates: 2–dose plus infection (16% [9 – 22]); 3–dose plus infection (21% [17 – 25]). Older age, male sex, obesity, coexisting diseases, immunosuppressant use, smoking, and alcohol drinking were associated with lower antibody titers, whereas these associations disappeared after 3–dose, except for sex (lower in female participants) and immunosuppressant use. Antibody waning was faster in older participants, females, and alcohol drinkers after 2–dose, whereas it did not differ after 3–dose across except sex. Conclusions The 3–dose mRNA vaccine conferred higher durable antibody titers, and previous infection further enhanced its durability. The antibody levels at a given time point and waning speed after 2–dose differed across background factors; however, these differences mostly diminished after 3–dose.

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“…Age, 6,8,9 sex, 9 BMI, 16 hypertension, 6,8 diabetes, 17 smoking, 8,9 alcohol consumption, 18 and days after vaccine 8 are potential modifiers of vaccine‐induced SARS‐CoV‐2 antibody levels. We thus included these factors as covariates in the analyses.…”

Section: Methodsmentioning

confidence: 99%

Dyslipidemia and SARS‐CoV‐2 spike antibody titres after the second and third doses of the BNT162b2 vaccine among healthcare workers in Japan

Islam

Yamamoto

Mizoue

et al. 2022

Diabetes Metabolism Res

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Objective This study aimed to examine the sex‐associated differences in the relationship between dyslipidemia and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike immunoglobulin (Ig)G antibodies among BNT162b2 vaccine recipients. Methods Participants were staff members (aged 21–75 years) of a medical and research institution who underwent an anti‐SARS‐CoV‐2 spike IgG antibody test after the second (n = 1872) and third doses (n = 1075) of the BNT162b2 vaccine. Dyslipidemia was defined as triglyceride level ≥150 mg/dl, high‐density lipoprotein‐cholesterol level <40 mg/dl, low‐density lipoprotein‐cholesterol level ≥140 mg/dl, or lipid‐lowering medication use. Multivariable linear regression was used to calculate the ratio of means for SARS‐CoV‐2 spike IgG titre according to dyslipidemia status. Results The prevalence of dyslipidemia was 38.0% in men and 19.6% in women. The relationship between dyslipidemia and SARS‐CoV‐2 spike IgG titres after the second dose differed markedly by sex (P for interaction <0.001). In men, dyslipidemia was associated with significantly lower IgG titres: the ratio of means (95% confidence interval) was 0.82 (0.72–0.93). However, this association disappeared after the third dose (0.96 [0.78–1.18]). Of the dyslipidemia components, hypertriglyceridemia was inversely associated with SARS‐CoV‐2 spike IgG antibody titre after both the second and third doses (ratio of means: 0.82 [0.70–0.95] and 0.73 [0.56–0.95], respectively). In women, IgG titres did not differ according to dyslipidemia or hypertriglyceridemia status after either dose. Conclusions These results suggest a detrimental role of hypertriglyceridemia in the humoral immune response to the BNT162b2 vaccine for COVID‐19 in men but not in women.

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Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers

Cited by 20 publications

References 20 publications

Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine

Towards a Future of Personalized Vaccinology: Study on Individual Variables Influencing the Antibody Response to the COVID-19 Vaccine

Durability and determinants of anti-SARS-CoV-2 spike antibodies following the second and third doses of mRNA COVID-19 vaccine

Dyslipidemia and SARS‐CoV‐2 spike antibody titres after the second and third doses of the BNT162b2 vaccine among healthcare workers in Japan

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