Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington’s disease

Busse, Monica; Hughes, Gareth; Wiles, C. M.; Rosser, Anne Elizabeth

doi:10.1007/s00415-008-0964-x

Cited by 67 publications

(64 citation statements)

References 36 publications

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“…The strength testing protocol discriminated between patients with MS who had mild-to-moderate disability and controls and, thus, may be a useful tool to identify weakness in people with MS. People with MS were significantly weaker in all muscle groups tested in the lower extremities and trunk, which is consistent with findings in people with Huntington's disease. 21 Less has been reported on the discriminant validity of the non-HHD assessments used in this study, but the mean ± SD values from the present study are comparable with = SD√ (1−ICC). The MDC is a measure of the minimal change needed to exceed the measurement error, where MDC 95 = SEM*1.96*√ 2.…”

Section: Discussionsupporting

confidence: 46%

“…Little has been reported on discriminant validity of strength measured by HHD in people with neurologic conditions. 21 In people with MS, HHD measurements of knee strength have been shown to discriminate between disability levels, 22 but, to our knowledge, discriminant validity of HHD between people with MS and controls has not been reported.…”

Section: Participantsmentioning

confidence: 87%

“…Handheld dynamometry has been found to have high test-retest reliability in controls, [23][24][25][26] in elderly persons who fall, 27 and in other neurologic populations. 21,[28][29][30][31] In people with MS, test-retest reliability of HHD has been reported only for knee flexion and extension, where it has been shown to have acceptable reliability. 22 Test-retest reliability has not been investigated in the ankle, hip, or trunk in people with MS.…”

Section: Participantsmentioning

confidence: 99%

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Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis

Mañago¹,

Hebert²,

Schenkman³

2017

International Journal of MS Care

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Background: Strength training in people with multiple sclerosis (MS) is an important component of rehabilitation, but it can be challenging for clinicians to quantify strength accurately and reliably. This study investigated the psychometric properties of a clinical strength assessment protocol using handheld dynamometry and other objective, quantifiable tests for the lower extremities and trunk in people with MS.

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Section: Discussionsupporting

confidence: 46%

Section: Participantsmentioning

confidence: 87%

Section: Participantsmentioning

confidence: 99%

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Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis

Mañago¹,

Hebert²,

Schenkman³

2017

International Journal of MS Care

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“…It has been previously found to be a reliable method of assessing muscle strength in people with diseases such as Huntington chorea 11 and other neurologic conditions.…”

Section: Methodsmentioning

confidence: 99%

Between-Rater Reliability of the 6-Minute Walk Test, Berg Balance Scale, and Handheld Dynamometry in People with Multiple Sclerosis

Toomey¹,

Coote²

2013

International Journal of MS Care

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This study investigated the between-rater reliability of the Berg Balance Scale (BBS), 6-Minute Walk test (6MW), and handheld dynamometry (HHD) in people with multiple sclerosis (MS). Previous studies that examined BBS and 6MW reliability in people with MS have not used more than two raters, or analyzed different mobility levels separately. The reliability of HHD has not been previously reported for people with MS. In this study, five physical therapists assessed eight people with MS using the BBS, 6MW, and HHD, resulting in 12 pairs of data. Data were analyzed using intraclass correlation coefficients (

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“…These defects are the result of involuntary and prolonged contractions. Examinations of HD skeletal muscle have demonstrated atrophy, metabolic and mitochondrial defects, nonspecific histological abnormalities, and a loss of strength (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Far more studies of HD have focused on the central nervous system, and the motor defects are widely considered to be the result of neurodegeneration (1,2,8).…”

mentioning

confidence: 99%

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction

Waters

Varuzhanyan

Talmadge

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Huntington disease is a progressive and fatal genetic disorder with debilitating motor and cognitive defects. Chorea, rigidity, dystonia, and muscle weakness are characteristic motor defects of the disease that are commonly attributed to central neurodegeneration. However, no previous study has examined the membrane properties that control contraction in Huntington disease muscle. We show primary defects in ex vivo adult skeletal muscle from the R6/2 transgenic mouse model of Huntington disease. Action potentials in diseased fibers are more easily triggered and prolonged than in fibers from WT littermates. Furthermore, some action potentials in the diseased fibers self-trigger. These defects occur because of decreases in the resting chloride and potassium conductances. Consistent with this, the expression of the muscle chloride channel, ClC-1, in Huntington disease muscle was compromised by improper splicing and a corresponding reduction in total Clcn1 (gene for ClC-1) mRNA. Additionally, the total Kcnj2 (gene for the Kir2.1 potassium channel) mRNA was reduced in disease muscle. The resulting muscle hyperexcitability causes involuntary and prolonged contractions that may contribute to the chorea, rigidity, and dystonia that characterize Huntington disease.

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Use of hand-held dynamometry in the evaluation of lower limb muscle strength in people with Huntington’s disease

Cited by 67 publications

References 36 publications

Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis

Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis

Between-Rater Reliability of the 6-Minute Walk Test, Berg Balance Scale, and Handheld Dynamometry in People with Multiple Sclerosis

Huntington disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction

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