Use of growth factors in ACL surgery: preliminary study

Abstract

There is no general consensus on the use of growth factors (GF) in surgery.

Platelet-Rich Plasma Use in Anterior Cruciate Ligament Surgery: Systematic Review of the Literature

“…Regarding ACL graft maturation, there is some promising evidence that the addition of PRP to the graft or tunnels could be a synergic factor in acquiring maturity more quickly than grafts with no PRP. 10,13,20,22 There were 2 studies that showed a tendency toward this outcome, but the small sample size numbers probably made it difficult to obtain statistically significant differences between the groups. 16,21 There was 1 study that showed no differences regarding maturation when using or not using PRP in ACL reconstruction.…”

“…Ventura et al, 10 regarding graft maturation, presented CT data that showed a significant difference between groups (P < .01), with PRP ACL graft similar to native ACL tissue, whereas untreated grafts showed a more heterogeneous nature. From the clinical aspect, they found no differences in Knee Injury and Osteoarthritis Outcome Score, KT-1000 measurement, or Tegner score between the PRP group and control group at 6 months.…”

“…The first study regarding PRP in ACL surgery was published by Ventura et al 10 in 2005. They randomly assigned 20 patients to ACL hamstring reconstruction with or without PRP.…”

RETRACTED ARTICLE: Comparison of double-bundle anterior cruciate ligament reconstruction with and without autologous conditioned serum application

“…Biological signalling proteins are the driving force behind growing number of groups working on the use of platelet-rich plasma (PRP) as an adjunct treatment after surgery [19,29,34,35,40]. However, it is noteworthy that recent articles appear not to have found bone tunnel widening reduction with PRP [29,39].…”

Clinical Applications of Plasma Growth Factors

“…It has been seen that the PRP is useful in chronic Achilles tendinopathy especially when infiltrations Ozone [8,9,10], patellar tendinopathy [5,6,11], previously used in repairing cuff rotators [12,13,14], repair the anterior cruciate ligament [11] or with plasty erector or tibial bone-tendon graft-bone, meniscal repair the knee joint [5,6], in the reconstruction of the glenoid labrum or hip and ultimately partial and total muscle injury made here open repair and strengthening PRP later [7,19].…”