Use of Granulocyte-Macrophage Colony Stimulating Factor for Treatment of Drug-Induced Agranulocytosis

Wallach, Frances; Zirn, Jonathan R.; Murray, Henry W.; Tepler, Jeffrey; Luger, Norton M.

doi:10.1093/clinids/13.3.523

Cited by 11 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early surgical debridement is usually delayed because of severe persistent neutropenia [4], Therapeutic benefits of white blood cell transfusions arc not constant [5]. Recombinant hematopoietic growth factors -G-CSF or granulocytemacrophage colony-stimulating factor (GM-CSF) -were successfully used in toxic or drug-induced neutropenia [6,7]. We believe that G-CSF contributed to improve the prognosis in our patient.…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic Growth Factors in Treatment of Necrotizing Cellulitis Patients with Drug-Induced Neutropenia

Souidi¹,

Chosidow²,

Cordonnier³

et al. 1993

Dermatology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Hematopoietic Growth Factors in Treatment of Necrotizing Cellulitis Patients with Drug-Induced Neutropenia

Souidi¹,

Chosidow²,

Cordonnier³

et al. 1993

Dermatology

View full text Add to dashboard Cite

show abstract

Risks of rhG-CSF treatment in drug-induced agranulocytosis

et al. 1995

View full text Add to dashboard Cite

Nine patients with drug-induced agranulocytosis received recombinant human granulocyte colony-stimulating factor (rhG-CSF) to accelerate myeloid recovery because of life-threatening infections related to neutropenia. All patients showed a quick recovery of their granulocyte counts. Side effects were substantial, however. Three patients, two with a severe infection and one with preexisting pulmonary infiltrates, developed worsening of their respiratory status during neutrophil recovery, resulting in clinical manifestations of the adult respiratory distress syndrome (ARDS). In view of these major complications, the exact place of hematopoietic growth factors in the treatment of drug-induced agranulocytosis remains to be determined.

show abstract

Treatment of drug-induced agranulocytosis with recombinant granulocyte colony-stimulating factor (rh G-CSF)

Willfort

Lorber

Kapiotis³

et al. 1993

Ann Hematol

View full text Add to dashboard Cite

Five patients with drug-induced agranulocytosis received 300 micrograms recombinant human granulocyte colony-stimulating factor (rh G-CSF) subcutaneously twice daily for 2-5 days. G-CSF therapy resulted in a steep increase of the neutrophil count, which was faster than that in patients with spontaneous recovery reported in the literature. In all four patients with infectious complications fever rapidly declined with the increase of granulocytes. G-CSF may be useful in the management of drug-induced agranulocytosis.

show abstract

Use of Granulocyte-Macrophage Colony Stimulating Factor for Treatment of Drug-Induced Agranulocytosis

Cited by 11 publications

References 4 publications

Hematopoietic Growth Factors in Treatment of Necrotizing Cellulitis Patients with Drug-Induced Neutropenia

Hematopoietic Growth Factors in Treatment of Necrotizing Cellulitis Patients with Drug-Induced Neutropenia

Risks of rhG-CSF treatment in drug-induced agranulocytosis

Treatment of drug-induced agranulocytosis with recombinant granulocyte colony-stimulating factor (rh G-CSF)

Contact Info

Product

Resources

About