Use of Golden Syrian Hamster as an Animal Model to Study Leptospirosis-Associated Immune Responses

Cagliero, Julie; Huet, Karl; Matsui, Mariko

doi:10.1007/978-1-0716-0459-5_22

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Cited by 3 publications

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“…For in vivo study of flaA and flaB gene expression, 6–8-week old healthy animals ( n ≥ 5 individuals per condition) were infected and experiments were carried out as previously described ( 21 ). Briefly, OF1 mice and hamsters were IP injected with 2 × 10 8 virulent L. interrogans Icterohaemorrhagiae strain Verdun in 500–800 μL of EMJH medium, as recently reviewed ( 25 ). After euthanasia with CO 2 , whole blood was rapidly collected by cardiac puncture at 24 h p.i.…”

Section: Methodsmentioning

confidence: 99%

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella

et al. 2020

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Holzapfel et al. TLR5 Evasion by Leptospires the FlaB, but not the FlaA subunits. Altogether, in contrast to different bacteria that modify their flagellin sequences to escape TLR5 recognition, our study suggests that the peculiar central localization and stability of the FlaB monomers in the periplasmic endoflagellae, associated with the downregulation of FlaB subunits in hosts, constitute an efficient strategy of leptospires to escape the TLR5 recognition and the induced immune response.

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Section: Methodsmentioning

confidence: 99%