Use of gold seeds as tumor bed markers

Nag, Subir; Abdou, Jiddou; Scruggs, Granger R.

doi:10.1002/jso.20312

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Typically, the local recurrences are controlled by adjuvant radiation therapy. However, the delineation of tumor bed for radiation therapy is highly variable among radiation oncologists. − This discrepancy among radiation therapy planning is of particular concern for APBI, in which only the tumor bed is irradiated. Our results show that aPTT can greatly reduce the risk of local recurrences by utilizing the heat generated by GBP-PEG upon laser irradiation to eliminate residual malignant cells, if any, after breast-conserving surgery.…”

Section: Discussionmentioning

confidence: 99%

Adjuvant Photothermal Therapy Inhibits Local Recurrences after Breast-Conserving Surgery with Little Skin Damage

Wang

Hong

et al. 2017

ACS Nano

View full text Add to dashboard Cite

Adjuvant treatments following breast-conserving surgery (BCS) are essential to reduce the risk of local recurrences in patients with breast cancer. However, current adjuvant treatments are based on ionizing radiation, which brings radiation-induced damage and amplifies the risk of death. Here we explore the feasibility of using non-ionizing light to induce photothermal therapy as an adjuvant treatment to BCS. In an orthotopic breast cancer mice model, we demonstrate that adjuvant photothermal therapy (aPTT) decreases the incidence of local recurrences after BCS with no expense of cosmetic outcome. In comparison with conventional photothermal therapy, the technique used in aPTT provides more uniformly distributed light energy and less risk of skin burns and local recurrences. Overall, this work represents a departure from the traditional concept of using PTT as an alternative to surgery and reveals the potential of using PTT as an alternative to adjuvant radiation therapy, which is valuable especially for patients susceptible to radiation damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Adjuvant Photothermal Therapy Inhibits Local Recurrences after Breast-Conserving Surgery with Little Skin Damage

Wang

Hong

et al. 2017

ACS Nano

View full text Add to dashboard Cite

show abstract

“…Such fiducial markers are also used for setup verification prior to radiation dose delivery that is mostly conducted using cone‐beam CT in image‐guided RT. Fiducial markers have been successfully applied in a variety of treatment sites to provide guidance . Endoscopy‐/EUS‐guided implantation of fiducial markers has recently been shown feasible in esophageal cancer patients .…”

Section: Introductionmentioning

confidence: 99%