Use of gold nanoparticles as crosslink agent to form chitosan nanocapsules: Study of the direct interaction in aqueous solutions

Prado‐Gotor, Rafael; López-Pérez, G.; Martín, Miguel; Cabrera‐Escribano, Francisca; Franconetti, Antonio

doi:10.1016/j.jinorgbio.2014.03.005

Cited by 24 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research efforts are currently focused on structure–property relationships of polymer nanocomposites, as well as in quantifying the role of nanofiller/matrix interfacial interactions on nanocomposite properties, to further shed light on the mechanisms behind these reinforcements [ 24 – 28 ]. One hypothesis that has gained significant support in recent years is that strong polymer/nanofiller interactions facilitate the formation of non-covalent or pseudo crosslinks, and thereby contribute to enhancements in polymer properties [ 18 , 29 – 33 ]. In this study, our initial objective was to conduct experiments in further support of the pseudo crosslinking hypothesis using synthetic polyacrylamide (pAAM) hydrogels incorporating silica nanoparticles (SiNPs) as the model system.…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite Hydrogels

et al. 2015

View full text Add to dashboard Cite

Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and modeling analyses, has not fully elucidated the mechanistic underpinnings behind these enhancements. Moreover, few studies have focused on developing an understanding among two or more polymer properties affected by incorporation of nanomaterials. In our study, we investigated the elastic and thermal properties of poly(acrylamide) hydrogels containing silica nanoparticles. Both nanoparticle concentration and size affected hydrogel properties, with similar trends in enhancements observed for elastic modulus and thermal diffusivity. We also observed significantly lower swellability for hydrogel nanocomposites relative to neat hydrogels, consistent with previous work suggesting that nanoparticles can mediate pseudo crosslinking within polymer networks. Collectively, these results indicate the ability to develop next-generation composite materials with enhanced mechanical and thermal properties by increasing the average crosslinking density using nanoparticles.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite Hydrogels

et al. 2015

View full text Add to dashboard Cite

show abstract

“…CS has been employed as a reducing and stabilizing agent in the synthesis of metallic nanoparticles (Huang and Yang 2004;Wu et al 2008;Regiel et al 2013) and as a coating agent to design nanoparticle systems able to act as sensors or drug carriers (Bhattarai et al 2008;Regiel et al 2013;Prado-Gotor et al 2014). However, few works have been devoted to directly study the influence of solution parameters on the interaction between CS and nanoparticles (Prado-Gotor et al 2014). The goal of the present paper is to evaluate the role of CS in preventing AuNP aggregation in salty solutions and reveal the kind of structures formed when an AuNP suspension and a solution of CS of medium molecular weight are mixed.…”

Section: Introductionmentioning

confidence: 99%

Aggregation behaviour of gold nanoparticles in presence of chitosan

et al. 2015

View full text Add to dashboard Cite

Chitosan (CS) is a biocompatible polysaccharide with positive charge that is widely used as a coating agent for negatively charged nanoparticles. However, the types of structures that emerge by combining CS and nanoparticles as well as their behaviour are still poorly understood. In this work, we characterize the nanocomposites formed by gold nanoparticles (AuNPs) and CS and study the influence of CS in the expected aggregation process that should experience those nanoparticles under the favourable conditions of low pH and high ionic strength. Thus, at the working CS concentration, we observe the existence of CS structures that quickly trap the AuNPs and avoid the formation of nanoparticle aggregates in environmental conditions that, otherwise, would lead to such an aggregation.

show abstract

“…As shown in recent works, the addition of AuNPs into the hydrogel provides conductive properties and enhance cell proliferation. 16 Although some authors have mentioned that an ionic crosslinking may take place among chitosan molecules and citrate-capped AuNPs, 17,18 to our knowledge, no work has reported on the chitosan hydrogel crosslinked by covalent bond with AuNP. The crosslinking by covalent bond between chitosan and AuNPs brings the advantage of higher stability over the ionic crosslinking provided by the citrate-capped AuNPs or in situ synthesized AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Chitosan hydrogel covalently crosslinked by gold nanoparticle: Eliminating the use of toxic crosslinkers

Tenório

Montanheiro

Santos

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Tissue engineering has directed a lot of effort toward the development of devices with suitable biocompatibility and mechanical properties. Chitosan has been pointed as a valuable material to be applied in scaffolds due to its antimicrobial activity and biocompatibility. Nevertheless, the low mechanical resistance associated with the requirement of toxic crosslinkers has hampered translational application of chitosan hydrogel. Herein, the use of gold nanoparticles (AuNP) as crosslinker is reported as a great strategy to obtain chitosan hydrogel without using toxic reactants. In addition, the resultant chitosan hydrogel, crosslinked by AuNP of 30 nm (AuNP30), presented outstanding properties compared to chitosan hydrogel crosslinked by glutaraldehyde. Chitosan hydrogel crosslinked by AuNP30 presented lower porosity, which provided lower swelling degree and slower degradation rate. In addition, compressive strength was about two times higher than the chitosan hydrogel crosslinked by glutaraldehyde. The crosslink by AuNP30 also increased the biocompatibility of the hydrogel. Chitosan hydrogel crosslinked by AuNP30 did not show cytotoxicity against MEF cells, whereas cell viability of cells incubated with extract from chitosan hydrogel crosslinked by glutaraldehyde was only 41%. In conclusion, the results reported herein pointed that the use of AuNP30 as crosslinker agent provided to chitosan hydrogel enhanced properties that made it suitable to application in biomedical devices.

show abstract

Use of gold nanoparticles as crosslink agent to form chitosan nanocapsules: Study of the direct interaction in aqueous solutions

Cited by 24 publications

References 34 publications

Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite Hydrogels

Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite Hydrogels

Aggregation behaviour of gold nanoparticles in presence of chitosan

Chitosan hydrogel covalently crosslinked by gold nanoparticle: Eliminating the use of toxic crosslinkers

Contact Info

Product

Resources

About