Use of glycerolized cadaver skin for the treatment of scalds in children

Peeters, Rudi L.; Caluwé, D. De; Neetens, C.; Hubens, A

doi:10.1016/0305-4179(94)90086-8

Cited by 15 publications

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“…The operative treatment of DDPT burns is also recommended by Engrav [4] and Gray [6]. Peeters [18], Brans [1], Moerman [15], and others describe the management of DDPT burns using human cryopreserved and glycerolpreserved allograft skin. Other authors have noted that, in contrast to FT burns, there is still a possibility of self-re-epithelialisation with DDPT burns.…”

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confidence: 99%

Comparison of the Results of Operative and Conservative Treatment of Deep Dermal Partial-Thickness Scalds in Children

et al. 2007

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Deep dermal partial-thickness scalds remain one of the most common types of injuries in childhood. Local treatment of those wounds, alternatively described as IIb degree, is still very controversial. Some authors advise conservative treatment of such wounds, pointing to their ability to self-reepithelialise, which is possible but significantly prolonged. Other investigators postulate operative treatment, i.e., tangential necrectomy and split-thickness autologous skin grafting, which may shorten the time of wound healing. Arguments call for contra-arguments, and the problem still seems to be unresolved. There is indeed a lack of acceptable standardisation of the local treatment for deep dermal partial-thickness scalds in the paediatric population. The results of both conservative and operative treatment of 114 children aged between 3 months and 17 years, treated for deep dermal partial-thickness scalds from 1997 to 2004 are presented. The treatment of five groups of patients, divided into groups based on the extent of their burn wounds, is evaluated. The patients were treated by tangential necrectomy and skin grafting, mechanical dermabrasion, Granuflex(R) (Convatec) hydrocolloid dressings, Iruxol Mono(R) (Knoll) enzymatic dressings, or Aquacel Ag(R) (Convatec) hydrofibre dressings with silver ions. A number of parameters of wound healing were analysed. The results of this paper encouraged us to present and discuss a proposition for the standardisation of local treatment of deep dermal partial-thickness burn wounds in the paediatric population, according to the extent of injury.

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confidence: 99%

Comparison of the Results of Operative and Conservative Treatment of Deep Dermal Partial-Thickness Scalds in Children

et al. 2007

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“…In clinical medicine, allograft and/or commercialized artificial skin have been used in extensive burn patients to promote dermis recovery, to evade bacterial contamination, and to prevent body fluid and body temperature loss. After the regeneration of the dermis, the cadaver or commercialized artificial skin (1–3) will be removed, and then a split‐thickness autograft will be applied on the wound bed for epidermis growth (4,5). This so‐called “two‐step grafting” process is now the orthodox procedure in clinical practice for extensive burn patients.…”

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confidence: 99%

Biomimetic Bilayered Gelatin‐Chondroitin 6 Sulfate‐Hyaluronic Acid Biopolymer as a Scaffold for Skin Equivalent Tissue Engineering

Wang

Huang

et al. 2006

Artificial Organs

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In order to develop an adequate scaffold for skin tissue engineering, a bilayered gelatin-chondroitin 6 sulfate-hyaluronic acid membrane with a different pore size on either side was prepared. A rete ridges-like topographic microporous structure, which provided the paracrine crosstalk in the epithelial-mesenchymal interactions, was formed. Chondroitin-6-sulfate and hyaluronic acid were incorporated within the gelatin membrane to mimic skin composition and create an appropriate microenvironment for cell proliferation, differentiation, and migration. In the study, the lower layer of the membrane (pore size: 150 microm) was seeded with dermal fibroblasts and acted as the feeder layer for keratinocyte inoculation. Meanwhile, the upper layer (pore size: 20-50 microm) was seeded with keratinocytes for epidermalization. The dermal fibroblasts were dynamically seeded in a self-designed spinner flask for more even cell distribution. The keratinocytes were cultured in submerged conditions for 5 days and then in an air-liquid interface condition for further differentiation. After being cultured for 21 days, the upper layer, seeded with keratinocytes, developed into an epidermis-like structure while the lower part, which was seeded with dermal fibroblasts developed into a dermis-like structure. A histological examination and immunostain were used to prove that keratinocytes maintain their phenotype and stratified epidermis layers were formed within 21 days. In brief, the bilayered skin substitute with biological dermal analog and epidermal structure was successfully fabricated. From this study, we can suggest that the culture model is suitable for autologous skin equivalent preparation.

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“…A outra utilização do EAPG é como um curativo biológico, seja no tratamento de queimaduras de espessura parcial superficial 30,72,73,74 em feridas com exposição de estruturas como vasos, nervos, tendão ou osso, em pacientes com necrólise epidérmica tóxica 26 , ou ainda, como cobertura de enxerto autógeno em malha muito expandido 69 . Nestes casos, o EAPG atua como um curativo colocado sobre a ferida, mantido no lugar pela adesividade à fibrina.…”

Section: O Método De Glicerolizaçãounclassified

Enxertos combinados de derme alógena residual, preservada em glicerol, sobreposta por pele autógena, como cobertura definitiva de queimaduras pofundas - relato de casos

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Use of glycerolized cadaver skin for the treatment of scalds in children

Cited by 15 publications

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Comparison of the Results of Operative and Conservative Treatment of Deep Dermal Partial-Thickness Scalds in Children

Comparison of the Results of Operative and Conservative Treatment of Deep Dermal Partial-Thickness Scalds in Children

Biomimetic Bilayered Gelatin‐Chondroitin 6 Sulfate‐Hyaluronic Acid Biopolymer as a Scaffold for Skin Equivalent Tissue Engineering

Enxertos combinados de derme alógena residual, preservada em glicerol, sobreposta por pele autógena, como cobertura definitiva de queimaduras pofundas - relato de casos

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