Use of gated myocardial perfusion imaging to assess clinical value of Xinmailong injection in chronic congestive heart failure

Liu, Yan; Wang, Zhiqian; Xiao, Wenliang; Li, Yuan

doi:10.1016/s0254-6272(15)30062-5

Cited by 13 publications

(12 citation statements)

References 3 publications

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“…This protection by XML was evident from echocardiographic analysis of left ventricular wall thickness and cardiac function. Similar changes in cardiac tissue have been reported in patients with chronic congestive heart failure (Liu et al, 2014b;Ma et al, 2013). Thus, XML consistently the improved survival rate of rats treated with XML to EPI-induced cardiac dysfunction (Fig.…”

Section: Influence Of Xml On Left Ventricle Wall Thickness and The Ejsupporting

confidence: 82%

“…Xinmailong Injection, a bioactive composite extracted from Periplaneta americana, can dilate coronary arteries, antagonize the activation of neuroendocrine systems, increase blood supply to cardiac muscle, improve cardiac function, and antagonize ventricular restructuring (Liu et al, 2014b). The present study examined the possible protective effect of XML on EPI-induced heart failure in a rat model.…”

Section: Resultsmentioning

confidence: 99%

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Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Mao

Zhang

et al. 2016

Journal of Ethnopharmacology

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Section: Influence Of Xml On Left Ventricle Wall Thickness and The Ejsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Mao

Zhang

et al. 2016

Journal of Ethnopharmacology

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“…Liu et al . assessed the effects of XML injection in clinical HF patients for 3 months 4 using Gated Myocardial Perfusion Imaging (G-MPI) to evaluate left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV) and left ventricular end-systolic volume (LVESV). They found that LVEDV, LVESV, and plasma BNP levels were significantly lower, while LVEF was significantly higher in the XML group than in the control group (all P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Xinmailong (XML), a bioactive composite extracted from periplaneta Americana ( Fig. 1a ), has been widely used in China to treat patients with HF 4 5 . As shown in Fig.…”

mentioning

confidence: 99%

Mechanisms of Chinese Medicine Xinmailong’s protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes

Tan

et al. 2017

Sci Rep

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Patients with heart failure (HF) have high mortality and mobility. Xinmailong (XML) injection, a Chinese Medicine, is clinically effective in treating HF. However, the mechanism of XML’s effectiveness on HF was unclear, and thus, was the target of the present study. We created a mouse model of pressure-overload-induced HF with transverse aortic constriction (TAC) surgery and compared among 4 study groups: SHAM (n = 10), TAC (n = 12), MET (metoprolol, positive drug treatment, n = 7) and XML (XML treatment, n = 14). Dynamic changes in cardiac structure and function were evaluated with echocardiography in vivo. In addition, H9C2 rat cardiomyocytes were cultured in vitro and the phosphorylation of ERK1/2, AKT, GSK3β and protein expression of GATA4 in nucleus were detected with Western blot experiment. The results showed that XML reduced diastolic thickness of left ventricular posterior wall, increased ejection fraction and fraction shortening, so as to inhibit HF at 2 weeks after TAC. Moreover, XML inhibited the phosphorylation of ERK1/2, AKT and GSK3β, subsequently inhibiting protein expression of GATA4 in nucleus (P < 0.001). Together, our data demonstrated that XML inhibited the TAC-induced HF via inactivating the ERK1/2, AKT/GSK3β, and GATA4 signaling pathway.

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“…They showed that xinmailong was efficient in activating the PI3K/Akt signaling pathway and suppressing the Erk1/2 and P38 MAPK signaling pathways. Xinmailong prevented left ventricle dilatation and improved cardiac function (Liu et al, 2014 ; Wang X. et al, 2014 ; Li et al, 2016 ). Additionally, xinmailong treatment dramatically enhanced the survival rate of rats with epirubicin-induced HF.…”

Section: Protective Effects Of Traditional Chinese Medicine and Its Cmentioning

confidence: 99%

A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

Yang

Liu

et al. 2018

Front. Pharmacol.

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Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.

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Use of gated myocardial perfusion imaging to assess clinical value of Xinmailong injection in chronic congestive heart failure

Cited by 13 publications

References 3 publications

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

Mechanisms of Chinese Medicine Xinmailong’s protection against heart failure in pressure-overloaded mice and cultured cardiomyocytes

A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

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