Use of galvanostatic coulometry in the analysis of arbidol drug

Абдуллина, С. Г.; Petrova, I.K.; Лира, О. А.; Ziyatdinova, Guzel; Budnikov, H. C.

doi:10.1134/s1061934812010029

J Anal Chem

2012

DOI: 10.1134/s1061934812010029

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Use of galvanostatic coulometry in the analysis of arbidol drug

С. Г. Абдуллина

I.K. Petrova

О. А. Лира

et al.

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Cited by 2 publications

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“…8,9 To determine the concentration of umifenovir in biological fluids as well as pharmaceutical formulations, only a relatively small number of analytical techniques have been published. The majority of them are focused on high-performance liquid chromatography (HPLC), 14,15 liquid chromatography-electrospray ionization mass spectrometry (LC-ESI/MS), 16 HPLC-tandem mass spectrometry (MS/MS), 17 coulometry, 18 ultrafast liquid chromatography (UFLC), 19 and high-performance thin-layer chromatography (HPTLC). 20 Nevertheless, no studies have been conducted to determine umifenovir utilizing voltammetric approaches.…”

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The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media

Özok¹,

Kıran²,

Yunusoğlu³

et al. 2023

J. Electrochem. Soc.

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An electroanalytical procedure for sensing umifenovir (arbidol) by square wave adsorptive stripping voltammetry (SW-AdSV) was developed utilizing an anodically pretreated boron-doped diamond electrode. Measurements of umifenovir using cyclic voltammetry with phosphate buffer solution (PBS, 0.1 M, pH 2.5) revealed irreversible behaviour, adsorption-controlled as well as an ill-defined (+1.13 V, PA1) and a well-defined (+1.47 V, PA2) two oxidation peaks. Umifenovir oxidations depend critically on supporting electrolytes and pH. The second oxidation peak (PA2) current of the umifenovir was enhanced by adding sodium dodecyl sulfate (SDS, anionic surfactant) in the chosen supporting electrolyte. Umifenovir was quantified using its second oxidation peak (PA2) at about +1.39 V. Using the optimized condition, the oxidation peak current of PA2 showed a linear relationship for umifenovir determination in the concentration range from 0.005 to 1.0 μg mL-1 (9.73x10-9-1.95x10-6 M), with a detection limit of 0.0014 μg mL-1 (2.72x10-9 M) in PBS (PH 2.5) with SDS. Finally, the developed approach was successfully utilized to determine umifenovir in the pharmaceutical formulation and urine samples. To the best of our knowledge, this is the first electroanalytical approach for voltammetric sensing of umifenovir.

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confidence: 99%

The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media

Özok¹,

Kıran²,

Yunusoğlu³

et al. 2023

J. Electrochem. Soc.

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Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

Belov,

Dyshin,

Khodov

2024

Journal of Molecular Liquids

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Use of galvanostatic coulometry in the analysis of arbidol drug

Cited by 2 publications

References 3 publications

The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media

The First Electroanalytical Study Of Umifenovir (Arbidol) Used As A Potential Antiviral Drug For The Treatment of SARS-CoV-2: A Voltammetric Quantification On The Boron-Doped Diamond Electrode By Using Anionic Surfactant Media

Conformational analysis of arbidol in supercritical carbon Dioxide: Insights into 'opened' and 'closed' conformer groups

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