Use of French lyophilized plasma transfusion in severe trauma patients is associated with an early plasma transfusion and early transfusion ratio improvement

Nguyen, Cédric; Bordes, Julien; Cungi, Pierre-Julien; Esnault, Pierre; Cardinale, Michaël; Mathais, Quentin; Cotté, Jean; Beaume, Sébastien; Sailliol, A.; Prunet, Bertrand; Meaudre, Éric

doi:10.1097/ta.0000000000001801

Cited by 34 publications

(50 citation statements)

References 22 publications

(32 reference statements)

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“…There were also significantly less cases of massive transfusion utilization and RBC transfusion in the FLyP group compared to the FFP group (7 vs. 45%). No differences in hospital length of stay, ICU length of stay, or 24-h mortality between the two groups were noted [87].…”

Section: French Lyophilized Plasma (Flyp)mentioning

confidence: 84%

“…A dried plasma product introduced in the USA will allow for earlier plasma administration starting prehospital and continuing into the hospital setting, which will likely improve patient outcomes, as demonstrated by the French experience [87]. Dried plasma should certainly replace the recommended crystalloid administration in the ATLS guidelines, which were designed to accommodate all levels of practice and take into account the variable availability of blood products.…”

Section: Future Of Lyophilized Plasmamentioning

confidence: 99%

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Dried Plasma

Zaza¹,

Kalkwarf²,

Holcomb³

2019

Damage Control Resuscitation

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Section: French Lyophilized Plasma (Flyp)mentioning

confidence: 84%

Section: Future Of Lyophilized Plasmamentioning

confidence: 99%

Dried Plasma

Zaza¹,

Kalkwarf²,

Holcomb³

2019

Damage Control Resuscitation

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“…Of the nine included studies, one study was an RCT comparing FDP to FFP , while eight studies were nonrandomized. Of the eight nonrandomized studies, two studies had a control group: one study compared FDP to FFP and one study compared FDP + RBC to whole blood . The six other studies were uncontrolled .…”

Section: Resultsmentioning

confidence: 99%

Freeze‐dried plasma in major haemorrhage: a systematic review

et al. 2020

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Background and objectives Freeze-dried plasma (FDP) has logistical advantages in terms of storage and reconstitution time compared to fresh-frozen plasma. In vitro studies show FDP to be equivalent to fresh-frozen plasma regarding coagulation and clotting capacities. FDP is used in an increasing number of countries. We wanted to evaluate the clinical effects of FDP in major haemorrhage compared to standard care.Methods MEDLINE, Embase, Central, Biosis Previews, WHO ICTRP, Clinical Trials and Open Grey were systematically searched from inception until September 2018, without language restriction. Studies were eligible if they examined haemorrhagic adult patients transfused with FDP. Our primary outcome was mortality. Two reviewers independently assessed studies for eligibility, extracted data and assessed bias.Results Nine studies were eligible for inclusion. Three studies had a comparison group: one was a randomized controlled trial and two were before and after comparisons. Six studies were uncontrolled. A total of 606 patients received FDP, while 72 patients received non-FDP transfusion. In total, five minor adverse effects were documented. Two studies compared FDP to fresh-frozen plasma and found no difference in 30-day mortality between the groups. The included studies were heterogenous and had several methodological weaknesses, such as no control group, missing data or no protocol. ConclusionsThe available research does not document the clinical effects of FDP. We cannot recommend or discourage use of FDP in major haemorrhage on base of available research.

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“…French lyophilized plasma (FLYP) has been used in military operations around the world and has also been authorized in France for civilian use in austere settings . A recent randomized trial indicated that the use of FLYP in trauma patients resulted in improved coagulation parameters and better early transfusion ratios compared to FFP . In July 2018, FLYP was approved by the FDA for limited use by the US military .…”

Section: Dried Plasma Is Most Urgently Neededmentioning

confidence: 99%

“…33 A recent randomized trial indicated that the use of FLYP in trauma patients resulted in improved coagulation parameters and better early transfusion ratios compared to FFP. 34,35 In July 2018, FLYP was approved by the FDA for limited use by the US military. 36 While meeting a short-term urgent need, this is considered a limited, temporary measure until a US product can attain FDA approval to meet the longer-term military requirement.…”

Section: Dried Plasma Is Most Urgently Neededmentioning

confidence: 99%

The need for dried plasma – a national issue

et al. 2019

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Recent studies have demonstrated that early transfusion of plasma or RBCs improves survival in patients with severe trauma and hemorrhagic shock. Time to initiate transfusion is the critical factor. It is essential that transfusion begin in the prehospital environment when transport times are longer than approximately 15 to 20 minutes. Unfortunately, logistic constraints severely limit the use of blood products in the prehospital setting, especially in military, remote civilian, and mass disaster circumstances, where the need can be most acute. US military requirements for logistically supportable blood products are projected to increase dramatically in future conflicts. Although dried plasma products have been available and safely used in a number of countries for over 20 years, there is no dried plasma product commercially available in the United States. A US Food and Drug Administration–approved dried plasma is urgently needed. Considering the US military, disaster preparedness, and remote civilian trauma perspectives, this is an urgent national health care issue.

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Use of French lyophilized plasma transfusion in severe trauma patients is associated with an early plasma transfusion and early transfusion ratio improvement

Abstract: Therapeutic, level IV.

Cited by 34 publications

References 22 publications

Dried Plasma

Dried Plasma

Freeze‐dried plasma in major haemorrhage: a systematic review

The need for dried plasma – a national issue

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