Use of Fomepizole in Pediatric Methanol Exposure: The First Case Report in Taiwan and a Literature Review

Chen, Tzu-Hua; Kuo, Chang-Hung; Huang, Chia-Tsuan; Wang, Weili

doi:10.1016/j.pedneo.2013.08.009

Cited by 4 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fomepizole-treated patients also showed fewer complications and the best outcome when compared with the non-fomepizole-treated patients. In agreement, a case report study had reported that the use of fomepizole prevented vision defects and stabilized vital signs of a 1 year old who ingested alcohol paste with 80% methanol [37]. In contrast, Holzman, Larsen (2021), reported that all cases of methanol poisoning died despite administering fomepizole and hemodialysis [29].…”

Section: Discussionmentioning

confidence: 76%

Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia

Alqurashi

Alhusayni

et al. 2023

JCM

View full text Add to dashboard Cite

Methanol poisoning is a challenging issue due to its inducing acute multiple organ failures, and especially due to a lack of preparedness, available antidotes, and management protocols. The current study presents six cases of methanol poisoning that attended the emergency department of King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia, between March and November 2022. All of the patients suffered from severe metabolic acidosis and visual impairment following the ingestion of homemade alcoholic beverages and colonia. Three patients were comatose, suffered from post-cardiac pulmonary arrest, and, finally, died, while the other three were non-comatose and discharged from the ICU after improvement. Management was based on clinical symptoms and other laboratory findings due to a shortage of methanol level measurement resources. The antidote, fomepizole, was not given to all of the cases due to its deficiency, and ethanol was given only to one patient due to difficulties in administering it without monitoring its concentration. Methanol poisoning and its outbreak provide insights into the dangers of hazardous homemade alcohol and other pharmaceutical preparations that might be adulterated with methanol, particularly to the shortage of suitable diagnostic testing and antidotes in addition to poor resources for management of intoxicated patients in some regions of Saudi Arabia.

show abstract

Section: Discussionmentioning

confidence: 76%

Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia

Alqurashi

Alhusayni

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…As it has been shown by other authors, inhibition of CYP2E1 by 4-MP significantly decreases oxidative stress [39]. The property of 4-MP to inhibit CYP2E1 and alcohol dehydrogenase is widely used to prevent poisoning with ethanol, methanol and ethylene glycol [39][40][41].…”

Section: Discussionmentioning

confidence: 84%

Protective Effects of CYP2E1 Inhibitors on Metabolic Syndrome-induced Liver Injury in Guinea Pigs

Rushchak

Shayakhmetova

Matvienko

et al. 2015

BBJ

View full text Add to dashboard Cite

This work was carried out in collaboration between all authors. Author VVR managed the analyses of the study, performed the statistical analysis and wrote the first draft of the manuscript. Author GMS managed the analyses of the study, managed the literature searches and wrote part of the manuscript. Author AVM managed the histopathology studies. Author MOC designed the study and wrote the protocol. All authors read and approved the final manuscript.

show abstract

“…Methanol is metabolized to toxic metabolites by alcohol dehydrogenase. Severe abdominal pain, retina toxicity, acidosis, convulsions, and coma are among its toxic effects (7,26). Exposure to high doses of methanol leads to severe clinical effects such as metabolic acidosis, CNS depression, hypotension, acute renal failure, and methanol blindness (16,26).…”

Section: Methanolmentioning

confidence: 99%

“…Fomepizole does not cause hypoglycemia and sedative side effects, and its tolerability is also more than ethanol. However, its higher cost compared to ethanol restricts its use in clinics (16,(26)(27)(28).…”

Section: Methanolmentioning

confidence: 99%

Evaluation of Common Non-pharmacological Chemical Substance Poisonings in Childhood

Ünüvar¹

2017

jpr

View full text Add to dashboard Cite

Songül Ünüvar ABS TRACTÖz Acute intoxications in adolescents and adults are mostly associated with intentional or accidental ingestions. Intoxications are commonly seen in children aged between 1 and 5 years and most of the cases are associated with accidental intake. In most of the children, no clinical symptoms related to intoxication are observed or only mild effects can develop. The main route of drug elimination is through kidneys. Absolute clearance in children is often lower than in adults but weight-adjusted clearance is higher. Depending on more rapid elimination in children the plasma half-life of the drug might be shorter in children than in adults. A shorter elimination half-life means that plasma steady-state is achieved with repeated doses. It is important to prevent childhood intoxications, and the use of child-resistant packaging and adequate supervision together with the secure storage of household substances are the basis of prevention of accidental childhood intoxications. Intoxications represent one of the most common medical emergencies in children, and epidemiological characteristics vary in different countries. Therefore, special epidemiological surveillance is necessary for each country to determine the problem according to which preventive measures should be taken. Early awareness and taking appropriate therapeutic measures seems to be effective in the reduction of mortality rate. The major and most common non-pharmacological chemical intoxications in childhood have been reviewed here with the intent of helping health-care professionals, particularly pediatricians to recognize and reduce the risk of harmful childhood intoxications. Keywords: Childhood, intoxication, child health, antidote Ergen ve yetişkinlerdeki akut zehirlenmeler çoğunlukla kasıtlı veya kazara alımlar ile ilişkilidir. Bir ve beş yaş arasındaki çocuklarda zehirlenmeler yaygın görülmektedir ve olguların çoğu kazara alımlara bağlıdır. Çocukların çoğunda zehirlenmeye bağlı hiçbir klinik belirti gözlenmez veya sadece hafif etkiler gelişebilir. İlaç eliminasyonu esas olarak böbrekler aracılığı ile olur. Çocuklarda mutlak klerens yetişkinlere göre genellikle daha düşüktür, fakat vücut ağırlığına göre hesaplanan klerens daha yüksektir. Çocuklarda daha hızlı eliminasyona bağlı olarak, ilacın plazma yarı ömrü yetişkinlere kıyasla daha kısa olabilir. Eliminasyon yarı-ömrünün daha kısa olması, plazma kararlı durumuna tekrarlanan dozlarda ulaşıldığı anlamına gelir. Çocukluk çağı zehirlenmelerinin önlenmesi önemlidir, çocuk emniyeti olan ambalaj kullanılması ve evsel ürünlerin kontrollü olarak güvenli muhafaza edilmeleri, kazara oluşan çocukluk çağı zehirlenmelerinin önlenmesinin esasını oluşturur. Zehirlenmeler, çocukluk çağında en sık görülen acil tıbbi durumlardan biridir ve epidemiyolojik özellikleri ülkeden ülkeye farklılık göstermektedir. Bu nedenle, sorunu belirlemek için hangi önleyici tedbirlerin alınabileceği konusunda her ülke için özel epidemiyolojik takip gereklidir. Zehirlenmelerde erken farkındalık ve uygun terapötik ...

show abstract

Use of Fomepizole in Pediatric Methanol Exposure: The First Case Report in Taiwan and a Literature Review

Cited by 4 publications

References 12 publications

Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia

Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia

Protective Effects of CYP2E1 Inhibitors on Metabolic Syndrome-induced Liver Injury in Guinea Pigs

Evaluation of Common Non-pharmacological Chemical Substance Poisonings in Childhood

Contact Info

Product

Resources

About