Use of fMRI in the Study of Chronic Aphasia Recovery After Therapy: A Case Study

Harnish, Stacy M.; Neils-Strunjaš, Jean; Lamy, Martine; Eliassen, James C.

doi:10.1310/tsr1505-468

Cited by 32 publications

(23 citation statements)

References 35 publications

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“…Interestingly, in three of these studies, the intervention approach was comprehensive in that it targeted multiple modalities and utilized a variety of different strategies, typically individualized to the person with aphasia’s specific deficits and strengths (Basso & Caporali, 2001; Harnish, Neils-Strunjas, Lamy, & Eliassen, 2008; Hinckley & Craig, 1998). In the fourth study two different treatments were compared at two different intensities (Pulvermuller et al, 2001), although participants randomized to the intensive treatment fared better, a clear statement of the effect of intensity alone cannot be made.…”

Section: Aphasia Treatment Intensity: State Of the Evidencementioning

confidence: 99%

Aphasia treatment: Intensity, dose parameters, and script training

Cherney

2012

International Journal of Speech-Language Pathology

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Studies of aphasia treatment have shown that intensive speech-language therapy is associated with significant improvements. However, there is no standard definition of intensity and the simplistic notion that “more is better” is not necessarily supported by the research. First, current evidence regarding intensity and aphasia treatment was briefly summarized. Second, studies that directly compare conditions of higher- and lower-intensity treatment for aphasia were reviewed with regard to the inclusion of parameters that contribute to a definition of intensity. In addition to five parameters proposed by Warren, Fey and Yoder (2007) and highlighted by Baker (2012), total number of sessions was also often documented. The review illustrated the complexity of quantifying the dose of comprehensive treatments that target multiple modalities and utilize a variety of different strategies. Third, data from a study reporting a relationship between intensive computer-based script training and outcomes in aphasia were examined. Results serve to illustrate Baker’s contention that intensity alone is insufficient without also considering the active ingredients of the teaching episode. Information about dose, therapeutic inputs, and client acts can lead to better optimization of an intervention.

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Section: Aphasia Treatment Intensity: State Of the Evidencementioning

confidence: 99%

Aphasia treatment: Intensity, dose parameters, and script training

Cherney

2012

International Journal of Speech-Language Pathology

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“…Harnish et al [38] analyzed the role of intensity of aphasia therapy using functional MRI (fMRI) to document changes in neural activation patterns associated with therapy in an individual with chronic conduction aphasia. They found that task improvement across fMRI testing sessions corresponded with increases in the fMRI blood oxygenation level dependent (BOLD) signal.…”

Section: Some Recent Advancesmentioning

confidence: 99%

A Review of Conduction Aphasia

Ardila

2010

Curr Neurol Neurosci Rep

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In this paper, a historical overview of the interpretation of conduction aphasia is initially presented. It is emphasized that the name conduction aphasia was proposed by Wernicke and was interpreted as a disconnection between the temporal and frontal brain language areas; this interpretation was re-taken by Geschwind, attributing the arcuate fasciculus the main role in speech repetition disturbances and resulting in the so-called Wernicke-Geschwind model of language. With the introduction of contemporary neuroimaging techniques, this interpretation of conduction aphasia as a disconnection syndrome due to an impairment of the arcuate fasciculus has been challenged. It has been disclosed that the arcuate fasciculus does not really connect Wernicke's and Broca's areas, but Wernicke's and motor/premotor frontal areas. Furthermore, conduction aphasia can be found in cases of cortical damage without subcortical extension. It is concluded that conduction aphasia remains a controversial topic not only from the theoretic point of view, but also from the understanding of its neurologic foundations.

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“…This deficit is typically tested in a naming task, where a patient is required to name visually presented objects or pictures of objects. While imaging overt speech is crucial for assessment of speech recovery in aphasic individuals, important insights on language recovery processes were obtained in fMRI studies that used the silent paradigm (Davies et al, 2006;Harnish et al, 2008). One problem related to using covert speech is that it prevents monitoring of task performance (Peck et al, 2004).…”

Section: Fmri Of Language Deficitsmentioning

confidence: 99%