Use of Fibrin Sealant in Thermal Injury

McGill, Victoria; Kowal-Vern, Areta; Lee, Martin; Greenhalgh, David G.; Gomperts, Edward D.; Bray, Gordon L.; Gamelli, Richard L.

doi:10.1097/00004630-199709000-00011

Cited by 39 publications

(34 citation statements)

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“…Two RCTs and four cohort studies (3 retrospective and 1 prospective) were included ( Table ). The sample size ranged from 18 to 250 individuals.…”

Section: Resultsmentioning

confidence: 99%

“…The control groups had SSGs secured with staples or a mixture of staples, sutures and dressings. Medical co‐morbidities were not reported in four studies. One study documented no co‐morbidities, and another reported smoking and diabetes only, with no significant difference between groups.…”

Section: Resultsmentioning

confidence: 99%

“…Overall wound healing was described by proportions healed on day 14 and at 1 month; time to complete healing was reported in two studies. One study did not report this outcome.…”

Section: Resultsmentioning

confidence: 99%

“…Boccara and colleagues reported complete wound closure after a mean of 17 days, but with no comparison between the six patients with treatment and control burn sites. McGill and co‐workers reported no significant difference between groups in wound healing time after adjustment for graft size (mean(s.d.) 5(4) versus 18(64) days per 100 cm 2 ; P = 0·77).…”

Section: Resultsmentioning

confidence: 99%

“…Two studies focused on blood loss and the use of blood products, rather than graft take or healing. Ihara and colleagues reported a blood transfusion requirement of 1226 ml in the fibrin glue group compared with 2038 ml in the control group.…”

Section: Resultsmentioning

confidence: 99%

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Systematic review of fibrin glue in burn wound reconstruction

Miller

Wormald

Wade

et al. 2019

British Journal of Surgery

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Background In the reconstruction of burns using split‐skin grafts (SSGs), fibrin glue can be used to improve graft take and reduce haematoma formation, although the efficacy and cost‐effectiveness are unknown. This systematic review evaluated outcomes of fibrin glue compared with conventional SSG attachment techniques. Outcomes of interest included SSG take, haematoma formation, patient satisfaction and cost‐effectiveness. Methods This PROSPERO‐registered review was performed in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and PRISMA statement. Embase, PubMed, Cochrane and http://clinicaltrial.gov databases were searched systematically. Observational and experimental studies comparing fibrin glue with other methods of SSG attachment in burn wounds were included. Risk of bias was assessed using the Cochrane risk‐of‐bias and Risk of Bias In Non‐Randomized Studies – of Intervention tools. The quality of the evidence was assessed using the GRADE tool. Results Two RCTs and four observational studies were included. Graft take at day 5 was not significantly different between groups (3 studies, 183 individuals). Fibrin glue significantly reduced the risk of postoperative haematoma in two studies and reduced patient‐reported pain in two studies, with suggested cost savings in four studies. All studies were at risk of methodological bias and the quality of the evidence was universally very low. Conclusion As the evidence is sparse, the quality very low and the risk of bias significant both within and across studies, it is not possible to make any recommendations regarding the use of fibrin glue in burn wounds.

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“…Two RCTs and four cohort studies (3 retrospective and 1 prospective) were included ( Table ). The sample size ranged from 18 to 250 individuals.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Overall wound healing was described by proportions healed on day 14 and at 1 month; time to complete healing was reported in two studies. One study did not report this outcome.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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