Use of Ergot Preparations in Migraine

Fuchs, M

doi:10.1001/jama.1950.02910520004003

Cited by 21 publications

(7 citation statements)

References 4 publications

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“…The patient ingested 120 mg of ergotamine tartrate; the maximum recommended dose is 4 mg/day, and 12 mg in one week. Myocardial ischaemia has been described after the administration of conventional doses of ergot derivatives in migrainous subjects with and without heart disease (Snell, Russell-Smith and Coysh, 1978), but myocardial infarction has been reported rarely (Goldfischer, 1960;Fuchs and Blumenthal, 1950). Ischaemia of the extremities due to ergot alkaloids is well recognized and historically is known as St Antony's Fire.…”

Section: Discussionmentioning

confidence: 99%

Self-induced myocardial infarction

Carr

1981

Postgraduate Medical Journal

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SummaryA case of acute myocardial infarction and peripheral vascular insufficiency following overdose with ergotamine is described. IntroductionDespite the prevalence of migraine and the widespread use of ergotamine preparations in its treatment, there are few reports of the effect of a massive overdose of these compounds. This case illustrates the consequences of an overdose of Migril, a compound containing 2 mg ergotamine tartrate B.P., 50 mg cyclizine hydrochloride B.P. and 100 mg caffeine hydrate B.P. per tablet.

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Section: Discussionmentioning

confidence: 99%

Self-induced myocardial infarction

Carr

1981

Postgraduate Medical Journal

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“…1,2 Substernal chest pain and discomfort suggestive of myocardial ischemia have been described with ergot preparations [ Table 1]. [3][4][5][6][7][8][9][10][11][12][13] Ergotamine taken orally in therapeutic doses has been associated with myocardial ischemia, 6,9,12 myocardial infarction, 4,13 cardiac arrest 4,14 and even sudden death 3 [ Table 1]. These complications have occurred with standard dosages more often than with overdosages.…”

Section: Discussionmentioning

confidence: 99%

Myocardial Ischemia Related to Ergot Alkaloids: A Case Report and Literature Review

et al. 1991

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Ergotamine tartrate and methysergide are widely used headache treatments with important vasoconstrictive properties. We report a 31-year-old man with cluster headaches who developed severe, prolonged myocardial ischemia following combination therapy with ergotamine tartrate and methysergide. We reviewed the cardiovascular complications of each agent alone and in combination. Given the pharmacologic similarity of these agents, we propose that they may have additive or synergistic cardiac toxicity, at least in vulnerable individuals. We recommend caution when these agents are used together.

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“…There have been several reports of myocardial ischaemia due to the use of ergotamine, for indications other than migraine, in patients with known heart disease (Labbe et al, 1929a;Lichtman, 1936;Scherf and Schlachman, 1948;McNerney and Leedham, 1950), and also in a case of thyrotoxicosis (Labbe, Justin-Besanion and Gouyen, 1929b). In a survey of the literature four cases of myocardial ischaemia occurring in previously healthy migraine sufferers have been found; in two of these angina occurred (Bailey Carter, 1940;Bemreiter, 1965), one developed a probable myocardial infarct (Fuchs and Blumenthal, 1950), and one a definite infarct (Goldfischer, 1960). A further complication of the use of ergotamine for migraine is that the drug itself may cause headache, and this may lead to an increase in dose by the patient, and the establishment of a vicious circle (Wainscott, Volans and Wilkinson, 1974).…”

Section: Discussionmentioning

confidence: 99%