Use of epinet database for observational study of status epilepticus in Auckland, New Zealand

Bergin, Peter; Jayabal, Jayaganth; Walker, Eleanor M.; Jones, P. G.; Yates, Kim; Thornton, Vanessa; Dalzeil, S.; Litchfield, Rhonda; Roberts, Lindsay R.; Timog, Jerelyn; Bennett, Patricia; Ao, Braden Te; Parmer, P.; Feigin, Valery; Davis, Suzanne L.; Beghi, Ettore; Rossetti, Andrea O.

doi:10.1016/j.jns.2015.08.490

Cited by 3 publications

(5 citation statements)

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“…The EpiNet study group was established to provide a platform to undertake multicenter collaborative research studies in epilepsy . We undertook a population‐based epidemiological incidence study of SE in greater Auckland, New Zealand (population = 1.614 million), using the EpiNet platform, with comprehensive data collection based on the new ILAE SE classification …”

Section: Introductionmentioning

confidence: 99%

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Status epilepticus in Auckland, New Zealand: Incidence, etiology, and outcomes

et al. 2019

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Objective To determine the incidence, etiology, and outcome of status epilepticus (SE) in Auckland, New Zealand, using the latest International League Against Epilepsy (ILAE) SE semiological classification. Methods We prospectively identified patients presenting to the public or major private hospitals in Auckland (population = 1.61 million) between April 6, 2015 and April 5, 2016 with a seizure lasting 10 minutes or longer, with retrospective review to confirm completeness of data capture. Information was recorded in the EpiNet database. Results A total of 477 episodes of SE occurred in 367 patients. Fifty‐one percent of patients were aged <15 years. SE with prominent motor symptoms comprised 81% of episodes (387/477). Eighty‐four episodes (18%) were nonconvulsive SE. Four hundred fifty episodes occurred in 345 patients who were resident in Auckland. The age‐adjusted incidence of 10‐minute SE episodes and patients was 29.25 (95% confidence interval [CI] = 27.34‐31.27) and 22.22 (95% CI = 20.57‐23.99)/100 000/year, respectively. SE lasted 30 minutes or longer in 250 (56%) episodes; age‐adjusted incidence was 15.95 (95% CI = 14.56‐17.45) SE episodes/100 000/year and 12.92 (95% CI = 11.67‐14.27) patients/100 000/year. Age‐adjusted incidence (10‐minute SE) was 25.54 (95% CI = 23.06‐28.24) patients/100 000/year for males and 19.07 (95% CI = 16.91‐21.46) patients/100 000/year for females. The age‐adjusted incidence of 10‐minute SE was higher in Māori (29.31 [95% CI = 23.52‐37.14]/100 000/year) and Pacific Islanders (26.55 [95% CI = 22.05‐31.99]/100 000/year) than in patients of European (19.13 [95% CI = 17.09‐21.37]/100 000/year) or Asian/other descent (17.76 [95% CI = 14.73‐21.38]/100 000/year). Seventeen of 367 patients in the study died within 30 days of the episode of SE; 30‐day mortality was 4.6%. Significance In this population‐based study, incidence and mortality of SE in Auckland lie in the lower range when compared to North America and Europe. For pragmatic reasons, we only included convulsive SE if episodes lasted 10 minutes or longer, although the 2015 ILAE SE classification was otherwise practical and easy to use.

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Section: Introductionmentioning

confidence: 99%

“…13,14 We undertook a population-based epidemiological incidence study of SE in greater Auckland, New Zealand (population = 1.614 million), 15 using the EpiNet platform, with comprehensive data collection based on the new ILAE SE classification. 16 We also compared population incidence using previous ILAE classifications.…”

Section: Introductionmentioning

confidence: 99%

Status epilepticus in Auckland, New Zealand: Incidence, etiology, and outcomes

et al. 2019

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“…14 The form contains subforms focused on SE Onset, Patient Care, History, and Outcome. 14 The form contains subforms focused on SE Onset, Patient Care, History, and Outcome.…”

Section: Se Form In Epinetmentioning

confidence: 99%

“…A structured online clinical record was created in EpiNet to collect comprehensive information regarding an episode of SE. 14 This study was approved by the Northern B New Zealand Ethics Committee and the research governance committees of Auckland District Health Board, Waitemata District Health Board, and Counties Manukau District Health Board. Informed consent was obtained from patients after they had recovered from their episode of SE; if patients did not or could not give informed consent retrospectively, the ethics committee gave us permission to record deidentified data in the EpiNet database.…”

Section: Se Form In Epinetmentioning

confidence: 99%

EpiNet study of incidence of status epilepticus in Auckland, New Zealand: Methods and preliminary results

et al. 2018

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The EpiNet project has been commenced to facilitate investigator-led collaborative research in epilepsy. A new Web-based data collection tool has been developed within EpiNet to record comprehensive data regarding status epilepticus and has been used for a study of status epilepticus in Auckland, New Zealand. All patients aged >4 weeks who presented to any of the five public hospitals and the major private hospital within Auckland city (population = 1.61 million) with an episode of status epilepticus between April 6, 2015 and April 5, 2016 were identified using multiple overlapping sources of information. For this study, status epilepticus was defined as any seizure exceeding 10 minutes in duration, or repeated seizures lasting >10 minutes without recovery between seizures. Patients who had either convulsive or nonconvulsive status epilepticus were included. Episodes of status epilepticus were classified according to the 2015 International League Against Epilepsy ILAE status epilepticus classification. A total of 477 episodes in 367 patients were considered as definite or probable status epilepticus; 285 episodes (62%) lasted >30 minutes, which is the duration that has previously been used for epidemiological studies of status epilepticus.

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“…First described in early writings of Antiquity and subsequently recognised by French physicians as a clinical entity ( état de mal épileptique ) since 1824, SE is a complex, heterogeneous condition which carries a high morbidity‐mortality depending on the cause, age of onset, seizure severity, and medical co‐morbidities, and where management remains a major challenge largely due to lack of evidence. Whilst ongoing trials will hopefully advance our status quo in the management of SE, its incidence, causes, responses to treatment and outcomes are also being determined in a New Zealand study . In the meantime, a clear therapeutic plan focusing on the initial stages (where evidence exists) by way of implementing integrated algorithms such as the suggested one is essential, for a prompt and accurate diagnosis will usually result in a better outcome.…”

mentioning

confidence: 99%

Algorithm for the treatment of status epilepticus: a New Zealand perspective

Iniesta

2017

Internal Medicine Journal

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Use of epinet database for observational study of status epilepticus in Auckland, New Zealand

Cited by 3 publications

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Status epilepticus in Auckland, New Zealand: Incidence, etiology, and outcomes

Status epilepticus in Auckland, New Zealand: Incidence, etiology, and outcomes

EpiNet study of incidence of status epilepticus in Auckland, New Zealand: Methods and preliminary results

Algorithm for the treatment of status epilepticus: a New Zealand perspective

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