Use of Enantioselective Synthesis and Preparative Chiral Chromatography to Access a Challenging Enantiopure Pharmaceutical Candidate from a Mixture of Four Stereoisomers

High throughput analysis enables high throughput experimentation in pharmaceutical process research

“…experience with them; they represent relatively simple instrumentation and I am certain that they will be indispensable in the laboratory of every organic chemist in the near future". 42 Gradually, we made inroads in the use of preparative chromatography in the syntheses of new clinical candidates, carrying out multikilogram separations using not only HPLC, [43][44][45][46] but also novel large scale preparative SFC equipment that we developed in partnership with Thar Technologies and Novasep. 47 Our analytical HPLC and SFC method development workflows enabled the rapid development of methods for preparative separations of newly prepared compounds, however, analytical chromatography experiments alone are insufficient for predicting preparative chromatographic performance at scale.…”