Use of enamel matrix protein derivative with minimally invasive surgical approach in intra-bony periodontal defects: clinical and patient-centered outcomes

Abstract

This case series evaluated the clinical performance and patient-centered outcomes after a minimally invasive surgical technique (MIST) associated with enamel matrix protein derivative (EMD), for the treatment of intra-bony defects. Twelve patients presenting teeth with probing depth >or=5 mm and bleeding on probing associated with radiographic evidence of intra-bony defect were treated by MIST associated with EMD. Clinical parameters were measured at baseline, 3 and 6 months. Patient perception during the intraoperative period and during the first postoperative week was evaluated. The use of MIST with EMD promoted significant improvements in clinical parameters, minimal pain/discomfort and maximum esthetics satisfaction. Within of limits of the present study, it could be shown that MIST combined with EMD for the treatment of intra-bony defects promotes satisfactory clinical and patient-centered outcomes.

Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis

“…The studies included a number of subjects ranging between 10 and 87. Only one study did not report the mean age of patients (Harrel, Wilson, & Nunn, ), while eleven did not report the age range of subjects (Aimetti et al, , Ghezzi et al, , Harrel et al, , Harrel, Wilson, & Nunn, , Harrel et al, , Ribeiro, Casarin, Palma, et al, 2011a, Ribeiro et al, , Ribeiro, Casarin, Palma, et al, 2011b, Ribeiro et al, , Schincaglia et al, , Trombelli et al, ). The overall age range of subjects analysed is 25–79 years.…”

“…The minimally invasive surgical technique (MIST) was used in eleven studies by different authors (Aimetti et al, ; Cortelini et al, ; Cortellini et al, ; Cortellini & Tonetti, , ; Cortellini & Tonetti, , ; Cosyn et al, ; De Bruyckere et al, ; Ghezzi et al, ; Ribeiro, Casarin, Palma, et al, 2011a; Ribeiro, Casarin, Palma, et al, 2011b; Ribeiro et al, , ), with the aid of an operating microscope. It consists of an envelope full‐thickness flap extended to the buccal and lingual aspects of the two teeth adjacent to the defect to expose 1–2 mm of the residual bone crest; flaps are then repositioned without any coronal displacement, and the suturing approach consists of a single modified internal mattress suture.…”

“…Regarding the use of grafts, these were tested in fourteen studies (Aimetti et al, , Cortellini et al, , Cortellini & Tonetti, , ; Cortellini et al, , Cortellini & Tonetti, , Cosyn et al, , De Bruyckere et al, , Ghezzi et al, , Harrel et al, , Ribeiro, Casarin, Palma, et al, 2011a, Ribeiro et al, , Schincaglia et al, , Trombelli et al, , Trombelli et al, ) (for details, see Table ).…”

Enhancing Periodontal Health Through Regenerative Approaches: A Commentary on the Need for Patient‐Reported Outcomes

“…Periodontists are clearly aware that pain is an outcome that deserves attention. Quite a number of researchers asked their patients to indicate their level of pain at different points in time after different types of periodontal surgery, 16‐20 or they focused on the degree to which patients reported dentin hypersensitivity after certain procedures 14,19‐21 …”

Enamel matrix protein derivatives: role in periodontal regeneration

“…In a case cohort study, Cortellini and Tonetti indicated that a minimally invasive surgical technique combined with EMD in the regenerative treatment of isolated intrabony defects resulted in excellent clinical improvements while limiting patient morbidity 111. The use of a minimally invasive surgical technique with EMD promoted significant improvements in clinical parameters, with minimal pain/discomfort and maximum esthetic satisfaction in the treatment of intrabony defects 112. No additional clinical benefits were apparent when using Emdogain in comparison with sites treated with a placebo (the Emdogain carrier alone) in deep and wide intrabony defects 113…”