Use of EBV PCR for the Diagnosis and Monitoring of Post-Transplant Lymphoproliferative Disorder in Adult Solid Organ Transplant Patients

Abstract

Epstein-Barr virus (EBV) is known to be involved in

Use of Serum Protein Electrophoresis to Monitor Patients with Post-transplant Lymphoproliferative Disorder

“…With potential risks of CT contrast dye and expense of the procedures, there is a need for a simple blood-based monitoring test. Epstein-Barr virus PCR of peripheral blood lymphocytes has been shown to be an effective diagnostic and monitoring tool in some patients (9). However the availability and expense of EBV PCR in many centers hinders its widespread use.…”

Post Transplant Lymphoproliferative Disorders After Liver Transplantation

“…Despite the consensus that PTLD patients have a significantly higher EBV-DNA load compared with healthy EBV-seropositive donors or non-PTLD transplant recipients, it is still unclear which threshold values are predictive for PTLD. Many different threshold values have been reported, all with different sensitivity (60-100%) and specificity (71-100%) (Lee TC et al, 2005;Rowe DT et al, 2001;Tsai DE et al, 2002). Another limitation of EBV-DNA load monitoring may be the observation that PTLD developing late after transplantation is not necessarily associated with EBV (negative staining for EBV in the tumour), and may therefore develop without a concomitant rise in EBV-DNA load.…”

Post-Trasplant Lymphoproliferative Disorders (PTLD) in Adult Kidney Trasplantated Patients

“…Despite the consensus that PTLD patients have a significantly higher EBV-DNA load compared with healthy EBV-seropositive donors or non-PTLD transplant recipients, it is still unclear which threshold values are predictive for PTLD. Many different threshold values have been reported, all with different sensitivity (60-100%) and specificity (71-100%) (Lee et al, 2005;Rowe et al, 2001;Tsai et al, 2002). Another limitation of EBV-DNA load monitoring may be the observation that PTLD developing late after transplantation is not Fig.…”