Use of Dynamic Contrast-Enhanced MRI in Multi-Centre Trials with Particular Reference to Breast Cancer Screening in Women at Genetic Risk

Leach, Martin O.

doi:10.1007/3-540-26420-5_15

Cited by 1 publication

(1 citation statement)

References 52 publications

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“…While it has become widely recognized that MRI offers unique information on the extent of disease, staging and recurrence, it is still too expensive to be practical as a screening tool for the general population. However, a number of groups are exploring the use of MRI in the screening of high-risk women who present with mutations in the BRCA1 or BRCA2 genes or an extensive family history of breast cancer (Leach 1998, Kuhl et al 1999, Stoutjesdijk et al 1999. This small group of women represents an ideal population for screening by MRI as it is only 0.1-0.2% of the general population, yet is responsible for 5-10% of all breast cancer (Ford et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Visualization and quantification of breast cancer biomechanical properties with magnetic resonance elastography

Plewes¹,

Bishop²,

Samani³

et al. 2000

Phys. Med. Biol.

288

200

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A quasistatic magnetic resonance elastography (MRE) method for the evaluation of breast cancer is proposed. Using a phase contrast, stimulated echo MRI approach, strain imaging in phantoms and volunteers is presented. First-order assessment of tissue biomechanical properties based on inverse strain mapping is outlined and demonstrated. The accuracy of inverse strain imaging is studied through simulations in a two-dimensional model and in an anthropomorphic, three-dimensional finite-element model of the breast. To improve the accuracy of modulus assessment by elastography, inverse methods are discussed as an extension to strain imaging, and simulations quantify MRE in terms of displacement signal/noise required for robust inversion. A direct inversion strategy providing information on tissue modulus and pressure distribution is described along with a novel iterative method utilizing a priori knowledge of tissue geometry. It is shown that through the judicious choice of information from previous contrast-enhanced MRI breast images, MRE data acquisition requirements can be significantly reduced while maintaining robust modulus reconstruction in the presence of strain noise. An experimental apparatus for clinical breast MRE and preliminary images of a normal volunteer are presented.

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Section: Introductionmentioning

confidence: 99%