Use of Diterpene Ginkgolides Meglumine Injection to Regulate Plasma Levels of PAI-1 and t-PA in Patients With Acute Atherosclerotic Cerebral Infarction

Abstract

Background: To: (i) explore the effect of diterpene ginkgolides meglumine injection (DGMI) on neurological deficit symptoms in acute atherosclerotic cerebral infarction (AACI) patients; (ii) measure the level of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA).Methods: Eighty AACI patients were divided equally and randomly into the DGMI group and control group. In addition to basic treatment, the DGMI group was treated with DGMI (25 mg/d) for 14 days. The control group had basic treatment without DGMI. Before and after treatment, the degree of neurological deficit was assessed, thromboelastography undertaken, and plasma levels of PAI-1 and t-PA measured. Results:The National Institutes of Health Stroke Scale score of patients in the DGMI group after treatment was lower than that in the control group, and the Barthel Index was higher than that in the control group (P < 0.05). Thromboelastography revealed that, in the DGMI group, the R value and K value after treatment were higher than before treatment, the angle and maximum amplitude value were lower than before treatment, and both were significant (P < 0.05). Compared with the control group, the plasma PAI-1 level of patients in the DGMI group was lower than that in the control group, and the t-PA level was higher than that in the control group (P < 0.05) after 14 days of treatment.Conclusions: DGMI may affect the activity of the blood coagulation and fibrinolysis system by regulating the plasma level of PAI-1 and t-PA, and improving neurological deficit symptoms. DGMI is important for improving the prognosis of patients with AACI.

Effect of Risk-Focused Diversified Safety Management Mode in Patients with Major Artery Stent Implantation

“…At this stage, some developed countries have begun to pay attention to the training of medical staff in patient safety education knowledge and have constructed a content system for patient safety education [15,16]. Diversity management is a human resource management activity, the basic principle of which is to recognize different problems in the work and adopt different methods to help solve them [17,18]. It can reach all aspects of the work and continuously improve the hidden problems in each of them, helping to improve the effectiveness of care.…”

The efficacy and safety of diterpene ginkgolides meglumine injection for cerebral infarction: A meta-analysis of randomized controlled trials

“…Out of 22 studies, 10 studies [13][14][15][16][19][20][21][22]28,31] were randomly grouped using the random number table method, while 1 study [25] was randomly grouped using the random sampling method. The selective bias caused by the random sequence in this study was evaluated as "low risk"; one study [18] mentioned a randomized double blind method, but did not mention a description of the relevant measures; 10 studies [12,17,23,24,26,27,29,30,32,33] only mentioned "random grouping" and were all evaluated as "unclear."…”

“…A total of 12 studies were included. [12][13][14][15][16][17][18][19]21,27,[29][30][31] We divided the patients into 3 subgroups based on their NHISS scores before treatment: mild ≤ 10 points, moderate to severe > 10 points, and unmentioned scores. [34] Mild stroke before treatment, NHISS ≤ 10 points: a total of 5 studies were included [12,14,17,30,31] using a fixed effects model.…”

“…A total of 20 studies were inclu ded. [12][13][14][15][16][17][18]20,[22][23][24][25][26][27][28][29][30][31][32][33] The meta-analysis results of the random effects model showed that the NHISS scores of the experimental group was lower than that of the control group, and the difference was statistically significant [MD = −2.04, 95%CI (−3.06, −1.03), P < .001] (shown in Fig. 4).…”

“…A total of 11 studies were inclu ded. [13][14][15]20,23,24,26,27,29,31,33] The meta-analysis results of the random effects model showed that the Barthel index of the experimental group was better than that of the control group, and the difference was statistically significant [MD = 7.49, 95%CI (5.17, 9.82), P < .001], as shown in Figure 5. According to the NHISS score of patients before treatment, they were divided into 2 subgroups: mild ≤ 10 points and moderate to severe > 10 points.…”