Use of Discriminant Analysis in
Relating Maternal Anti-D Levels to the Severity of
Haemolytic Disease of the Newborn

Morley, G.; Gibson, M.; Eltringham, D.

doi:10.1159/000467420

Cited by 7 publications

(8 citation statements)

References 9 publications

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“…The concentra tions of the anti-D were assayed using the Auto Analyzer [5]; anti-D (Jo) was found to have a In order to use this data it is necessary to cal culate the molar concentrations of the antigen and antibody. The 10% v/v cell suspension is equi valent to a concentration of 10» cells/ml.…”

Section: Methodsmentioning

confidence: 99%

A Study of Different Rhesus Phenotypes and their Binding Characteristics

Morley¹

1978

Vox Sanguinis

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A method has been developed using the AutoAnalyzer to study the binding characteristics of anti-D with cells of various rhesus phenotypes. A positive association has been demonstrated between site density and association constant. A hypothesis is proposed for the presence of two types of antigenic sites on the cell surface recognised only by affinity differences. The higher affinity site binds both arms of an IgG anti-D molecule, whereas the lower affinity site binds only one.

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Section: Methodsmentioning

confidence: 99%

A Study of Different Rhesus Phenotypes and their Binding Characteristics

Morley¹

1978

Vox Sanguinis

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“…The quantity of antibody has more clinical value [14,15,16]. However, it is not only the quantity but also the qualitative characteristics of the IgG-anti D antibodies (IgG-subclass) that determine the extent of red cell destruction [17,18,19,20], The subclass of antibodies greatly influences the process of adherence of sensitized cells to the IgG-receptors on phagocytes.…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and treatment of severe alloimmunization

Gravenhorst¹

1994

Vox Sanguinis

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“…The titre of maternal anti-D antibody in the direct antiglobulin test (IAGT) has little predictive value [26], The quantity of antibody has more clinical value [27][28][29], However, it is not only the quantity but also the qualita tive characteristics of the IgG-anti D antibodies (IgG subclass) that determine the extent of red cell destruction [30][31][32][33]. The subclass of antibodies greatly influences the process of adherence of sensitized cells to the IgG recep tors on phagocytes.…”

Section: D-antibodiesmentioning

confidence: 99%

Management of Serious Alloimmunization in Pregnancy

Gravenhorst¹

1988

Vox Sanguinis

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In the past 40 years, tremendous advances in the treatment of hemolytic disease have been made. The perinatal mortality has been reduced considerably. Rh immunoprophylaxis has decreased the incidence of Rh immunization to around 6 per 100,000 live births. Nevertheless, treatment of severe hemolytic disease is still essential. Increased reliability of diagnostic procedures have made early detection and optimal treatment of hemolytic disease possible. Treatment by plasmapheresis is still controversial. Although believed to be beneficial by some authors, conclusive evidence of its efficacy has not been obtained. With preterm induction of birth at 32 weeks of gestation, the chances for survival are 95%. Improvement of techniques and the use of modern real-time ultrasound equipment have made intrauterine intraperitoneal transfusion, in experienced hands, a relatively safe and successful procedure. Intravascular transfusion appears beneficial in early pregnancy. Combination of both techniques will probably be the answer for the future. The development of neonatal intensive care facilities has made a major contribution to the survival of children with haemolytic disease. The relative low incidence of haemolytic disease has made it imperative that treatment should take place in centers where experience and special skill are available.

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Use of Discriminant Analysis in Relating Maternal Anti-D Levels to the Severity of Haemolytic Disease of the Newborn

Cited by 7 publications

References 9 publications

A Study of Different Rhesus Phenotypes and their Binding Characteristics

A Study of Different Rhesus Phenotypes and their Binding Characteristics

Diagnosis and treatment of severe alloimmunization

Management of Serious Alloimmunization in Pregnancy

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