Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

Misaka, Kenji; Kishimoto, Takashi; Kawahigashi, Yuji; Sata, Michio; Nagao, Yumiko

doi:10.1159/000450679

Cited by 24 publications

(19 citation statements)

References 12 publications

(13 reference statements)

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“…From the availability of new direct‐acting anti‐retrovirals (DAAs) for treatment of hepatitis C (Chung et al, ), SVR can reach levels of almost 100% (Liang & Ghany, ), and thus, EHMs can be controlled when the immune tolerance is indirectly restored (Comarmond et al, ). The same has been reported for the treatment of OLP‐HCV, that is, exacerbation of OLP lesions occurs when hepatitis C is treated with interferon and ribavirin (Grossmann, Teixeira, de Aguiar, & do Carmo, ; Nagao, Kawaguchi, Ide, Kumashiro, & Sata, ), and their cure occurs in patients undergoing interferon‐free therapy with DAAs (Misaka, Kishimoto, Kawahigashi, Sata, & Nagao, ; Nagao, Kimura, Kawahigashi, & Sata, ).…”

Section: Discussionsupporting

confidence: 52%

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection

et al. 2019

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Objective: To verify whether there are differences between populations of CD8 + and FoxP3 + T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP-HCV) and lesions of idiopathic oral lichen planus (OLP-I). Materials and Methods:A case-control study was performed using a convenience sample of 11 paraffin-embedded tissue blocks of OLP-HCV and 19 of OLP-I.Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Immunohistochemistry was used to identify CD8 + and FoxP3 + T cells. The count of positive cells was compared between the two groups and correlated to clinical and demographic data (p < 0.05).Results: There were no statistically significant differences in the distribution of CD8 + and FoxP3 + T cells regarding the inflammatory infiltrate in lesions of OLP-HCV and OLP-I. Atrophic/erosive lesions showed a higher relationship between counts of CD8/FoxP3 T cells per mm 2 (p = 0.018) and counts of CD8 + T cells per mm 2 (p = 0.034) in OLP-HCV group compared to OLP-I group.Conclusion: Overall, no difference was found between cell populations in the lesions of OLP-HCV and OLP-I. However, atrophic/erosive lesions of OLP-HCV had a higher amount of CD8 + T cells and lower FoxP3 expression. K E Y W O R D SCD8, extra-hepatic manifestations, FoxP3, hepatitis C, oral lichen planus | 1101 de CAMARGO et Al. de CAMARGO et Al. | CON CLUS IONAlthough the present study has evidenced greater amount of CD8 + T cells and higher ratio of CD8/FoxP3 + cells in erosive/ulcerated lesions in the OLP-HCV group compared to the OLP-I group, more studies should be carried out to confirm this trend and to assess whether this characteristic can actually influence the treatment of this type of LP. CO N FLI C T S O F I NTE R E S TNone to declare. AUTH O R CO NTR I B UTI O N SCamargo AR performed data collection and tabulation. Tenório JR and Martins F participated in the acquisition of histological sections and immunohistochemical staining. Grando LJ and Corrêa EBD performed the statistical analyzes. Trierveiler M participated as a reviewer and did the immunohistochemical analysis. Ortega KL designed the study and participated in all phases of article review.

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Section: Discussionsupporting

confidence: 52%

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection

et al. 2019

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“…We showed that, of patients with OLP, 62% had HCV antibodies and 60% had HCV RNA in their serum [11]. Furthermore, there is evidence that treatment with DAAs improves OLP associated with HCV-related infection [12][13][14][15].…”

Section: Ehime Prefecturementioning

confidence: 78%

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Nagao¹,

Nishioka²,

Koresawa³

2019

obm hg

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“…Local conditions such as poor oral hygiene and smoking may exacerbate the risk of immune stimulation due to increased exposure [31,45]. There are reports about the association of OLP with a number of viral infections such as EBV, VZV, HSV, HPV, CMV, and HIV; the most common evidence of HCV is available [5,31,45,52].…”

Section: Etiologymentioning

confidence: 99%

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

Agha‐Hosseini

Samami

Tavakol

et al. 2019

J Islam Dent Assoc Iran

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Background and Aim: Oral lichen planus (OLP) is a chronic, inflammatory, T-cellmediated autoimmune oral mucosal disease. Oral lichenoid lesions develop as a type IV hypersensitivity reaction. Both of these entities are potential precancerous conditions; this adds to their clinical significance. The purpose of this literature review was to detect the similarities and the differences of these lesions to enhance the information of colleagues in managing these groups of patients. Materials and Methods: For this review, we searched Cochrane, Medline, and Embase databases from January 1990 to the end of October 2018. A total of 96 published papers, including review papers, case reports, cohort studies, case-control studies, and meta-analysis studies, were included and analyzed. Results: OLP and oral lichenoid reactions are two distinct diseases. They can be clinically similar but they have different etiologic factors. A histopathological study is necessary to differentiate them. Conclusion: The definitive diagnosis of these conditions is extremely important given their potentially premalignant nature. A timely diagnosis probably results in proper management. Based on the present research, the final differentiation between OLP and oral Lichenoid reactions relies on both clinical and histopathological manifestations according to the modified World Health Organization (WHO) criteria.

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Use of Direct-Acting Antivirals for the Treatment of Hepatitis C Virus-Associated Oral Lichen Planus: A Case Report

Cited by 24 publications

References 12 publications

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection

Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Oral Lichen Planus or Oral Lichenoid Reaction? A Literature Review

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