Use of Diffusion-Weighted MRI to Differentiate Chronic Pancreatitis From Pancreatic Cancer

Nutakki, Kavitha; Tahir, Bilal; Dhanabal, Aginiprakash; Tann, Mark; Coté, Gregory A.

doi:10.2214/ajr.12.10170

Cited by 52 publications

(33 citation statements)

References 35 publications

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“…Such applications include the differentiation of pancreatic adenocarcinoma from mass-forming chronic pancreatitis, the prediction of tumour grade and, finally, the prediction and early assessment of tumour response following neoadjuvant or palliative oncological therapy. Particularly for the differentiation of PDAC from mass-forming chronic pancreatitis, the reported data on the role of mono-exponential-based ADC calculations are contradictory [40], [41]. Interestingly, the IVIM-derived perfusion fraction f was shown to be able to differentiate between the two entities [37].…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models

Kartalis

Manikis

Loizou

et al. 2016

European Journal of Radiology Open

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ObjectivesTo compare two Gaussian diffusion-weighted MRI (DWI) models including mono-exponential and bi-exponential, with the non-Gaussian kurtosis model in patients with pancreatic ductal adenocarcinoma.Materials and methodsAfter written informed consent, 15 consecutive patients with pancreatic ductal adenocarcinoma underwent free-breathing DWI (1.5T, b-values: 0, 50, 150, 200, 300, 600 and 1000 s/mm2). Mean values of DWI-derived metrics ADC, D, D*, f, K and DK were calculated from multiple regions of interest in all tumours and non-tumorous parenchyma and compared. Area under the curve was determined for all metrics.ResultsMean ADC and DK showed significant differences between tumours and non-tumorous parenchyma (both P < 0.001). Area under the curve for ADC, D, D*, f, K, and DK were 0.77, 0.52, 0.53, 0.62, 0.42, and 0.84, respectively.ConclusionADC and DK could differentiate tumours from non-tumorous parenchyma with the latter showing a higher diagnostic accuracy. Correction for kurtosis effects has the potential to increase the diagnostic accuracy of DWI in patients with pancreatic ductal adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Diffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models

Kartalis

Manikis

Loizou

et al. 2016

European Journal of Radiology Open

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“…However, mass-forming FP showed no restriction of diffusion, without any significant difference between the ADC values of mass-forming focal pancreatitis and the remaining pancreas. Sandrasegaran et al[46] however found no significant difference between the signal intensity on DW images ( P = 0.82, P = 0.85) or ADC values ( P = 0.51, P = 0.76) between pancreatic cancer and chronic pancreatitis.…”

Section: Applications Of Dwi In Oncologymentioning

confidence: 98%

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

Mahajan

Deshpande

Thakur

2017

WJR

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“Personalized oncology” is a multi-disciplinary science, which requires inputs from various streams for optimal patient management. Humongous progress in the treatment modalities available and the increasing need to provide functional information in addition to the morphological data; has led to leaping progress in the field of imaging. Magnetic resonance imaging has undergone tremendous progress with various newer MR techniques providing vital functional information and is becoming the cornerstone of “radiomics/radiogenomics”. Diffusion-weighted imaging is one such technique which capitalizes on the tendency of water protons to diffuse randomly in a given system. This technique has revolutionized oncological imaging, by giving vital qualitative and quantitative information regarding tumor biology which helps in detection, characterization and post treatment surveillance of the lesions and challenging the notion that “one size fits all”. It has been applied at various sites with different clinical experience. We hereby present a brief review of this novel functional imaging tool, with its application in “personalized oncology”.

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“…In general, differentiation remains difficult. This also applies to the differentiation of these two pathologies via MRI even using DWI [42].…”

Section: Pancreatic Lymphomamentioning

confidence: 99%

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

Grözinger¹,

Grözinger²,

Horger³

2014

Fortschr Röntgenstr

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The review discusses the potential role of volume perfusion CT (VPCT) in the diagnosis and follow-up of different pathologies of the pancreas. VPCT enables a differentiation of different pancreatic tumors like adenocarcinoma or neuroendocrine tumors based on functional parameters like blood flow, blood volume and permeability. Furthermore, the article discusses the potential indications for VPCT imaging of inflammatory diseases of the pancreas such as acute or chronic pancreatitis and autoimmune pancreatitis. Key Points: ??VPCT may help to diagnose even small pancreatic tumors based on functional parameters ??Functional perfusion parameters can help to characterize pancreatic neoplasms ??In acute pancreatitis VPCT can evaluate the perfusion status of the organ Citation Format: ??Gr?zinger G., Gr?zinger A., Horger M. The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas. Fortschr R?ntgenstr 2014; 186: 1082???1093

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Use of Diffusion-Weighted MRI to Differentiate Chronic Pancreatitis From Pancreatic Cancer

Abstract: The addition of DWI to conventional MRI does not facilitate differentiation of pancreatic cancer from chronic pancreatitis.

Cited by 52 publications

References 35 publications

Diffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models

Diffusion-weighted MR imaging of pancreatic cancer: A comparison of mono-exponential, bi-exponential and non-Gaussian kurtosis models

Diffusion magnetic resonance imaging: A molecular imaging tool caught between hope, hype and the real world of “personalized oncology”

The Role of Volume Perfusion CT in the Diagnosis of Pathologies of the Pancreas

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