Use of dielectric barrier discharge ionization to minimize matrix effects and expand coverage in pesticide residue analysis by liquid chromatography-mass spectrometry

Lara-Ortega, Felipe J.; Robles-Molina, José; Brandt, Sebastian; Schütz, Alexander; Gilbert-López, Bienvenida; Molina‐Díaz, Antonio; García-Reyes, Juan F.; Franzke, Joachim

doi:10.1016/j.aca.2018.02.077

Cited by 37 publications

(19 citation statements)

References 41 publications

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“…With economic development in recent years, the number of ships has increased significantly and the existing oil–water separation devices cannot effectively treat oil-containing wastewater from ships that hold a large amount of emulsified oil. 1 The discharge of untreated wastewater into seawater can seriously harm the marine ecological environment, 2 therefore, the Marine Environment Protection Committee stipulates that the oil content in the discharged water body cannot exceed 15 ppm. 3 However, the components are complex due to the fact that marine oil-bearing wastewater contains a large amount of surfactant emulsification and inorganic ions that contain iron, and the standards required by the Marine Environment Protection Committee are difficult to meet.…”

Section: Introductionmentioning

confidence: 99%

Effective treatment of emulsified oil wastewater by the coagulation–flotation process

You

Zhang

et al. 2018

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Effective treatment of emulsified oil wastewater by the coagulation–flotation process

You

Zhang

et al. 2018

RSC Adv.

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“…In this work, the use of an active capillary plasma ionization source (based on DBDI), which was developed in our research group, 14,15 was explored for quantitative determination of fragrance allergens. Since DBDI is less affected by matrix effects and ion suppression than ESI and APCI, 16,17 it should allow the analysis of several fragrance allergens simultaneously without any prior chromatographic separation. In this way, the analysis time can be greatly reduced while the sensitivity is still satisfactory.…”

Section: Introductionmentioning

confidence: 99%

Rapid analysis of fragrance allergens by dielectric barrier discharge ionization mass spectrometry

Liu

Zenobi

2021

Rapid Comm Mass Spectrometry

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Rationale Fragrances are organic compounds with pleasant odors that are widely used in every aspect of our daily life; some fragrance ingredients can cause allergic reactions. Hence, the qualitative and quantitative analysis of fragrance allergens can prevent consumers coming into contact with these compounds. In this study, we evaluated the ability of a dielectric barrier discharge ionization (DBDI) source for analyzing allergens that occur in fragrances. Methods A home‐built liquid‐infusion device was used to evaporate the liquid samples. An active capillary plasma ionization source, which is based on a dielectric barrier discharge, was used to ionize the analytes. Mass spectra were acquired in positive ion mode with an LTQ Orbitrap mass spectrometer. Results Seven typical fragrance allergens were analyzed in this study. The limits of detections (LODs) were as low as 0.0001 ppm and a linear dynamic range of 2–3 orders of magnitude was achieved. Allergens in five different perfume products were successfully analyzed and quantified by this method, with analysis times of less than 1 min per sample. Conclusions This work introduces a DBDI‐MS‐based analytical method for detecting and quantifying fragrance allergens. Since DBDI has the advantages of high sensitivity, simple operation and fast analysis time, it is very suitable for the rapid analysis of trace allergens in fragrances, and could easily be used for quality control of consumer products in the cosmetics market.

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“…[20] TheD BDI-MS method introduced here has similar performance in terms of throughput, sensitivity,a nd the ability to distinguish cell types than the recently reported CyESI-MS methodology. [19] However,c ompared to other ionization methods,D BDI has some unique properties,f or example,i ti sl ess affected by matrix effects and ion suppression than ESI, [21] it can analyze polar and nonpolar compounds simultaneously,and does not need vacuum condition. [20a, 22] Very recently,w eh ave applied an ESI-DBDI combination source to single plant cell analysis (data not shown here).…”

Section: Introductionmentioning

confidence: 99%

High‐Throughput Single‐Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma

Liu

Wang

et al. 2021

Angewandte Chemie

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Even populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity.Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic cancer cells. We also analyzed gene expression in a cancer genome atlas dataset and found that the mRNA level of a critical enzyme of lipid synthesis (ATP citrate lyase, ACLY) was upregulated in human pancreatic ductal adenocarcinoma (PDAC). Moreover, both an ACLY chemical inhibitor or a siRNA approach targeting ACLY could suppress the viability of PDAC cells. A significant reduction in lipid content in treated cells indicates that ACLY could be a potential target for treating pancreatic cancer.

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Use of dielectric barrier discharge ionization to minimize matrix effects and expand coverage in pesticide residue analysis by liquid chromatography-mass spectrometry

Cited by 37 publications

References 41 publications

Effective treatment of emulsified oil wastewater by the coagulation–flotation process

Effective treatment of emulsified oil wastewater by the coagulation–flotation process

Rapid analysis of fragrance allergens by dielectric barrier discharge ionization mass spectrometry

High‐Throughput Single‐Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma

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