Use of D-mannose in the prevention of recurrent lower urinary tract infection in women

Kuzmenko, A V; Kuzmenko, V V; Gyaurgiev, T A

doi:10.18565/urology.2020.3.128-132

Cited by 3 publications

(2 citation statements)

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“…After reviewing the abstracts, a total of 21 publications were identified that were fully read. Two studies were excluded as the full text was not in English (28,29), 11 studies (19,(30)(31)(32)(33)(34)(35)(36)(37)(38)(39) were excluded as they did not report the data on symptoms of UTI/cystitis, but only the risk of recurrent UTI or the frequency of UTI in patients submitted to urodynamics, and one (40) study was excluded as it reported a Visual Analogic Scale (VAS) evaluation of symptoms 12 months after study entry, but included women with rUTI without any specific indication of symptoms of UTI/cystitis at study entry.…”

Section: Systematic Reviewmentioning

confidence: 99%

Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

et al. 2022

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Several studies, reviews and meta-analyses have documented that D-mannose use lowers the risk of recurrent urinary tract infections (UTI), but its role in the treatment of UTI/cystitis-related symptoms is unclear. In particular, no systematic review has analyzed the role of treatment with D-mannose in acute UTI/cystitis. In this paper, we systematically reviewed the published data on the effect of D-mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. PubMed/Medline and EMBASE databases were searched, from 1990 to January 2022, using combinations of the following keywords: 'urinary tract infections', 'cystalgia', 'recurrent next urinary tract infection', 'cystitis', 'mannose', 'mannoside', 'D-mannose', 'bacteriuria', 'pyuria', 'pyelocystitis' with the appropriate Boolean modifiers (Limits: Human, English, full article). Studies were selected for the systematic review if they were clinical studies and reported original data, the number of patients using D-mannose alone or in association with other treatments, and the number of patients with symptoms of UTI/cystitis at trial entry and after the follow-up period. A total of seven studies were identified. D-mannose was given alone in two studies, and was associated with cranberry extract, Morinda citrifolia fruit extract, pomegranate extract, fructo-oligosaccharides, lactobacilli, and N-acetylcysteine in the others. All studies reported that symptoms decreased after treatment with D-mannose. Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D-mannose may be useful in the treatment of UTI/cystitis symptoms.

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Section: Systematic Reviewmentioning

confidence: 99%

Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

et al. 2022

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“…A safe supraphysiological dose of D-mannose has beneficial effects on individual health. D-mannose is widely used as a treatment for a congenital disorder of glycosylation [31,32] and recurrent UTIs [33,34]. Numerous studies have shown that D-mannose binds to the cilia of Escherichia coli, preventing bacterial attachment to the urothelium in UTIs [35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

D-Mannose prevents bone loss under weightlessness

Líu

et al. 2023

J Transl Med

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Background Astronauts undergo significant microgravity-induced bone loss during space missions, which has become one of the three major medical problems hindering human's long-term space flight. A risk-free and antiresorptive drug is urgently needed to prevent bone loss during space missions. D-mannose is a natural C-2 epimer of D-glucose and is abundant in cranberries. This study aimed to investigate the protective effects and potential mechanisms of D-mannose against bone loss under weightlessness. Methods The hind legs of tail-suspended (TS) rats were used to mimic weightlessness on Earth. Rats were administered D-mannose intragastrically. The osteoclastogenic and osteogenic capacity of D-mannose in vitro and in vivo was analyzed by micro-computed tomography, biomechanical assessment, bone histology, serum markers of bone metabolism, cell proliferation assay, quantitative polymerase chain reaction, and western blotting. RNA-seq transcriptomic analysis was performed to detect the underlying mechanisms of D-mannose in bone protection. Results The TS rats showed lower bone mineral density (BMD) and poorer bone morphological indices. D-mannose could improve BMD in TS rats. D-mannose inhibited osteoclast proliferation and fusion in vitro, without apparent effects on osteoblasts. RNA-seq transcriptomic analysis showed that D-mannose administration significantly inhibited the cell fusion molecule dendritic cell-specific transmembrane protein (DC-STAMP) and two indispensable transcription factors for osteoclast fusion (c-Fos and nuclear factor of activated T cells 1 [NFATc1]). Finally, TS rats tended to experience dysuria-related urinary tract infections (UTIs), which were suppressed by treatment with D-mannose. Conclusion D-mannose protected against bone loss and UTIs in rats under weightlessness. The bone protective effects of D-mannose were mediated by inhibiting osteoclast cell fusion. Our findings provide a potential strategy to protect against bone loss and UTIs during space missions.

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Urinary Microbiota Shift is Associated with a Decline in Renal Function in the Aging Kidney

et al. 2022

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Use of D-mannose in the prevention of recurrent lower urinary tract infection in women

Cited by 3 publications

References 0 publications

Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

Systematic review of the effect of D‑mannose with or without other drugs in the treatment of symptoms of urinary tract infections/cystitis (Review)

D-Mannose prevents bone loss under weightlessness

Urinary Microbiota Shift is Associated with a Decline in Renal Function in the Aging Kidney

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