Use of Cyclosporine in Uterine Transplantation

Abstract

Uterine transplantation has been proposed as a possible solution to absolute uterine factor infertility untreatable by any other option. Since the first human attempt in 2000, various teams have tried to clarify which immunosuppressant would be most suitable for protecting the allogeneic uterine graft while posing a minimal risk to the fetus. Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. It is currently being tested as a potential immunosuppressant to be used during UTn. Its effect on the mother and fetus and its influence upon the graft during pregnancy have been of major concern. We review the role of CsA in UTn and its effect on pregnant transplant recipients and their offspring.

Transplante uterino: implicações reprodutivas, aplicabilidades clínicas e a experiência com nascidos vivos

“…É sabido que as alterações fisiológicas na gravidez incluem aumento do volume de distribuição e indução de atividades nos complexos enzimáticos que resultam em uma alteração do metabolismo. Embora não haja muitos estudos especificamente no contexto do transplante uterino, as principais questões relacionadas à imunossupressão na gravidez são a potencial teratogenicidade dos fármacos, o desenvolvimento de comorbidades, como doença renal, e infecções sistêmicas (Saso, 2012;Martin, 2021).…”

Uterus transplantation: Toward clinical application in Japan

“…[53][54][55][56][57][58][59] However, the significance of basic research using animals might be attenuated because the case number of human UTx is increasing steadily in the world and clinical knowledge has been accumulating. [60][61][62][63][64][65][66][67][68][69][70] Although the animal experiments might be useful for developing adequate surgical techniques that are associated with UTx, the implementation limits from the viewpoint of animal welfare should be considered further.…”