Use of cycles of compression to characterize the behaviour of apatitic phosphate powders

Pontier, Catherine; Champion, Éric; Viana, Marylène; Chulia, Dominique; Bernache‐Assollant, Didier

doi:10.1016/s0955-2219(01)00453-8

Cited by 27 publications

(11 citation statements)

References 9 publications

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“…1). The difference between total energy and expansion energy defines the (specific) net energy during compaction (A'BD) (Busignies et al, 2004;Michaut et al, 2010;Pontier et al, 2002;Rodriguez and Chulia, 2005;Vachon and Chulia, 1999).…”

Section: 'In-die' Measurementsmentioning

confidence: 99%

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

Grymonpré

Verstraete

Bockstal

et al. 2017

International Journal of Pharmaceutics

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As the number of applications for polymers in pharmaceutical development is increasing, there is need for fundamental understanding on how such compounds behave during tableting. This research is focussed on the tableting behaviour of amorphous polymers, their solid dispersions and the impact of hot-melt extrusion on the compaction properties of these materials. Soluplus, Kollidon VA 64 and Eudragit EPO were selected as amorphous polymers since these are widely studied carriers for solid dispersions, while Celecoxib was chosen as BCS class II model drug. Neat polymers and physical mixtures (up to 35% drug load) were processed by hot-melt extrusion (HME), milled and sieved to obtain powders with comparable particle sizes as the neat polymer. A novel approach was used for in-line analysis of the compaction properties on a rotary tablet press (Modul P, GEA) using complementary sensors and software (CDAAS, GEA). By combining 'in-die' and 'out-of-die' techniques, it was possible to investigate in a comprehensive way the impact of HME on the tableting behaviour of amorphous polymers and their formulations. The formation of stable glassy solutions altered the formulations towards more fragmentary behaviour under compression which was beneficial for the tabletability.Principal component analysis (PCA) was applied to summarize the behaviour during compaction of the formulations, enabling the selection of Soluplus and Kollidon VA 64 as the most favourable polymers for compaction of glassy solutions.

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Section: 'In-die' Measurementsmentioning

confidence: 99%

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

Grymonpré

Verstraete

Bockstal

et al. 2017

International Journal of Pharmaceutics

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“…In order to characterize the compression properties of the compacts, the compression processes were evaluated in terms of compression work, elastic work, compaction ratio and tensile strength as follows [52]:…”

Section: Compact Propertiesmentioning

confidence: 99%

Application of N-hexoyl chitosan derivatives with high degree of substitution in the preparation of super-disintegrating pharmaceutical matrices

Al-Remawi

2015

Journal of Drug Delivery Science and Technology

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“…Uygun bir yardımcı madde ve bu yardımcı maddelerin formülasyon içindeki seviyelerinin seçimi başarılı bir üretim için çok önemlidir. Doğrudan basım için formülasyon hazır-larken yardımcı maddenin basılabilirliği ve akıcılığı dikkate alınmalıdır [11][12][13][14][15][16].…”

Section: Gi̇ri̇ş Tabletunclassified

Tabletler Ve Tablet Basimina Etki Eden Kuvvetlerin Belirlenmesinde Kullanilabilecek Bazi Yeni Esitlikler

Halaçoğlu¹,

Uğurlu²

2015

MUSBED

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Use of cycles of compression to characterize the behaviour of apatitic phosphate powders

Cited by 27 publications

References 9 publications

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

Application of N-hexoyl chitosan derivatives with high degree of substitution in the preparation of super-disintegrating pharmaceutical matrices

Tabletler Ve Tablet Basimina Etki Eden Kuvvetlerin Belirlenmesinde Kullanilabilecek Bazi Yeni Esitlikler

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