Use of cyanoacrylate in the coaptation of edges of surgical wounds

Abstract

Cyanoacrylate has been used in several fields of different surgical specialties as an adhesive for closure of gingival flaps and in mucous and cutaneous lacerations. One of its advantages is that it has an excellent immunological response. In view of aesthetic needs, cyanoacrylate has been applied with satisfactory results, when compared with sutures. It presents better coaptation of edges of cutaneous and mucosal lesions, smaller residual scars, and biocompatibility. However, it is limited to areas of little tissue tension. This work attempts to provide a literature review with the aim of revealing the advantages of using tissue adhesives, especially cyanoacrylates, in wound coaptation in comparison with conventional methods.

The aplication of cyanoacrilate surgical glue on skin suture in rats

“…One half was directly taken to a freezer at -20°C to be subjected to the study of rupture strength and the other half was immediately fixed in 10% buffered forma-lin for the histological analysis 8 .…”

“…They are easily manipula-ble but show some drawbacks such as lower resistence in high tension areas when compared with conventional sutures and toxicity in some patients, one of the most rele-vant advantages is the surgical time reduction and the easy handling compared to oth-ers methods of synthesis 8 .…”

Oral Applications of Cyanoacrylate Adhesives: A Literature Review

“…The pain-free application procedure for these adhesives allows their use in cases where the anesthetic effect has diminished [5, 10, 36, 37] and for anxious or fearful patients [42] such as children. Moreover, cyanoacrylates do not exhibit genotoxic activity or systemic toxicity, and they do not cause mucosal irritation or cutaneous sensitivity [4, 8, 10, 43].…”

Erratum for the Research Article: “Engineering a highly elastic human protein–based sealant for surgical applications” by N. Annabi, Y.-N. Zhang, A. Assmann, E. S. Sani, G. Cheng, A. D. Lassaletta, A. Vegh, B. Dehghani, G. U. Ruiz-Esparza, X. Wang, S. Gangadharan, A. S. Weiss, A. Khademhosseini

“…Sealing wound tissue using sutures and staples can also be challenging and time-consuming and may not be possible in regions of the body that are not readily accessible (2). In addition, piercing tissues to place sutures and staples can further damage the surrounding wound area and can increase the risk for infection (1,3,4). Sealant materials have attracted attention as alternatives to seal and reconnect tissues or incorporate implant devices into tissues because of their ease of application and versatility (3,(5)(6)(7).…”

“…However, these surgical products cannot completely achieve the required adhesive and cohesive properties for lung incision sealing, such as tensile strength, elasticity, adhesive strength, and burst pressure resistance (20)(21)(22)(23)(24). Cyanoacrylate and gelatin-resorcinol-formaldehyde/glutaraldehyde glues have a much stronger adhesive strength to tissue, but their toxic degraded products prevent clinical translation (4,23). Their nondegradable polymer nature can also cause tissue irritation and infection (23).…”