Use of cyanoacrylate adhesives in dermal lesions: a review

Martín-Ballester, Antonio; García-Cerdá, David; Prieto‐Moure, Beatriz; Martı́n-Martı́nez, José Miguel; Lloris‐Carsí, José Miguel

doi:10.1080/01694243.2013.852784

Cited by 10 publications

(7 citation statements)

References 84 publications

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“…Cyanoacrylates are commonly used in human surgery, with favorable results. 11,12 In clinical studies in which researchers compared cyanoacrylates directly with skin staples or suture, cyanoacrylates had equal or lower SSI rates, had similar dehiscence rates, saved time in surgery, and were cost effective. [13][14][15] In the veterinary literature, celiotomy incision closure in dogs with 2-octyl cyanoacrylate (2OC) and a mesh was reported to be faster and had superior strength compared with an intradermal suture only.…”

Section: Introductionmentioning

confidence: 99%

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Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

2020

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Objective: To compare the prevalence of incisional complications after skin closure with n-butyl cyanoacrylate (NBC) or stainless-steel skin staples (SS) after ventral midline celiotomy for colic surgery in the horse. Study design: Retrospective study (2014-2018). Animals: Two hundred eighteen horses. Methods: Medical records of horses that underwent exploratory celiotomy for colic were included when the skin was closed with NBC or SS and the horse survived ≥15 days after surgery. Records and a follow-up questionnaire were used to determine in-hospital and posthospital discharge incisional complications. Associations between variables were assessed by using bivariable and multivariable analysis. Results: The cutaneous incision was closed with SS in 113 of 218 (51.8%) horses and with NBC in 105 of 218 (48.2%) horses. Follow-up information was available in 166 of 218 horses. Five horses with incisional complications prior to discharge but without follow-up were included in the overall analysis. Incisional complications were recorded in 17.5% (30/171) of horses, including 19.1% (17/89) of closures with SS and 15.9% (12/82) of closures with NBC (P = .54). Complications occurred before discharge in 14 of 218 (6.4%) horses and after discharge in 16 of 166 (9.6%) horses. Four horses with in-hospital incisional complications (surgical site infection) developed a second complication after discharge (hernia). Packed cell volume was a risk factor for in-hospital incisional complications (P = .04), and in-hospital incisional complications were associated with posthospital discharge incisional complications (P = .01).

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Section: Introductionmentioning

confidence: 99%

“…Cyanoacrylates are commonly used in human surgery, with favorable results 11,12 . In clinical studies in which researchers compared cyanoacrylates directly with skin staples or suture, cyanoacrylates had equal or lower SSI rates, had similar dehiscence rates, saved time in surgery, and were cost effective 13‐15 .…”

Section: Introductionmentioning

confidence: 99%

Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

2020

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“…PCA-based TAs offer several advantages, such as rapid and painless application, no requirement for complicated surgery and complex dressings, the prevention of microorganisms from entering the wounds, low dehiscence rates, and good tolerance and comfort with high patient satisfaction [ 97 ]. In contrast, several disadvantages, such as the limited strength in the presence of water or blood, low tensile strength, allergic concerns in patients, adverse reactions to asthma and deep burn wounds, and potential toxicity, have also been reported for PCA-based TAs [ 131 ].…”

Section: Representative Examples Of Polymeric Tasmentioning

confidence: 99%

Progress of tissue adhesives based on proteins and synthetic polymers

et al. 2023

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In recent years, polymer-based tissue adhesives (TAs) have been developed as an alternative to sutures to close and seal incisions or wounds owing to their ease of use, rapid application time, low cost, and minimal tissue damage. Although significant research is being conducted to develop new TAs with improved performances using different strategies, the applications of TAs are limited by several factors, such as weak adhesion strength and poor mechanical properties. Therefore, the next-generation advanced TAs with biomimetic and multifunctional properties should be developed. Herein, we review the requirements, adhesive performances, characteristics, adhesive mechanisms, applications, commercial products, and advantages and disadvantages of proteins- and synthetic polymer-based TAs. Furthermore, future perspectives in the field of TA-based research have been discussed.

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“…This class of adhesives has good biocompatibility, low residue, and low toxicity, but drawbacks include a slow curing process, complex preparation, and low viscosity; collagen-based adhesive products include GRF glue®, 12 Dermabond®, 13 and others, which have good biocompatibility and low toxicity, but suffer from being animal-derived, having low viscosity, and requiring longer adhesion times; α-cyanoacrylate adhesives include Cyanobond, Eastman 910, AronAlpha, etc . 14 Well-known examples are 504 coagulants (with butyl cyanoacrylate as the main component) and 508 medical adhesives (with octyl cyanoacrylate as the main component), which, although have a short adhesion time, produce a brittle glue layer and inevitably generate formaldehyde upon decomposition. However, to date, no adhesive product has been designed specifically for the adhesion of cartilage tissue after damage.…”

Section: Introductionmentioning

confidence: 99%