Use of Curare in Cataract Surgery

Kirby, Daniel B.

doi:10.1001/archopht.1950.00910010689006

Cited by 29 publications

(4 citation statements)

References 9 publications

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“…The rationale of the method used has already been discussed by Beaugie and Samuel (I973)v The present observation that the administration of tubocurarine lowers the IOP does not agree with that of Sadove and Unna (I951), who claimed no change in the IOP after tubocurarine, but it supports those of Colle, Duke-Elder, and Duke-Elder (I93I), Kirby (1950), Roche (I950), and Kornblueth, Aladjemoff, Magora, and Gobbay (959), who reported varying degrees of fall in IOP after tubocurarine. The fall in IOP was attributed both to muscle paralysis and to the fall in blood pressure that accompanies the use of tubocurarine (Colle and others,193I).…”

Section: Discussioncontrasting

confidence: 64%

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

Al-Abrak¹,

Samuel²

1974

British Journal of Ophthalmology

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The introduction of new anaesthetic drugs demands that their action should be compared with that of already established agents.Pancuronium bromide was introduced into clinical anaesthetic practice by Baird Material and methodsTen patients undergoing urological surgery (all males aged 3 I to 7 I yrs) were investigated, five being studied for each drug. The nature of the study was explained to each patient and written consent obtained.The methods were similar to those of a previous study by Beaugie and Samuel (I973). The respiratory and cardiovascular status was stabilized by the method of Samuel, Grange, and Hawkins (I968), substituting pancuronium for tubocurarine in the group in which pancuronium was studied.The patients were not premedicated. Either tubocurarine 0-5 mg./kg. body weight, or pancuronium bromide o i mg./kg. were injected intravenously followed by thiopentone 5 mg./kg. and pethidine i o mg./kg. The larynx was sprayed with lignocaine I00 mg. and a cuffed endotracheal tube introduced. Respiration was controlled with a Manley Ventilator set at constant pressure with a constant gas flow of I5 1./min. (nitrous oxide I0 1./min. and oxygen 5 1./min.) to minimize the effects of changes in intrathoracic pressure. The patients lay horizontal throughout the investigation.

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Section: Discussioncontrasting

confidence: 64%

Effects of general anaesthesia on the intraocular pressure in man. Comparison of tubocurarine and pancuronium in nitrous oxide and oxygen.

Al-Abrak¹,

Samuel²

1974

British Journal of Ophthalmology

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“…Hg (Schiotz) because of atony of the extrinsic eye muscles as there is no fall in blood pressure. The vitreous falls away from the anterior chamber, thus reducing the risk of loss (Kirby, 1950).…”

Section: Methodsmentioning

confidence: 99%

Anaesthesia for Intra-Ocular Surgery

Jk¹

1956

British Journal of Ophthalmology

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“…Durch Relaxation der extraokulären Muskeln senkt d-Tubocurarin den Augeninnendruck (6). In früheren Jahren verabreichte man bei Kataraktoperationen unter Lokalanästhesie kleine Mengen Curare, um den Prolaps von Augeninhalt zu verhindern (30). Wegen des Auftretens von respiratorischer Insuffizienz hat diese Methode jedoch bald ihre Popularität verloren.…”

Section: Muskelrelaxantien Nicht-depolarisierende Muskelrelaxantienunclassified