Use of Cumulative Live Birth Rate per Total Number of Embryos to Calculate the Success of IVF in Consecutive IVF Cycles in Women Aged ≥35 Years

Zhang, Meng; Bu, Tao; Tian, Haiqing; Li, Xia; Wang, Duolao; Wan, Xiaohui; Wang, Qingli; Mao, Xinmin; La, Xiaolin

doi:10.1155/2019/6159793

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…Further, we identified that the CLBR was significantly higher as the number of totals transferred was two. This result is different from the findings of previous research [ 58 ]. This could be due to high-quality embryos being preferentially selected for transfer, and women without obtained live birth needed to perform repeated embryo transfers.…”

Section: Discussioncontrasting

confidence: 99%

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Wang

Zhang

et al. 2023

JCM

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The cumulative live birth rate (CLBR) can better reflect the overall treatment effect by successive treatments, and continuous rather than categorical variables as exposure variables can increase the statistical power in detecting the potential correlation. Therefore, the dose–response relationships might find an optimal dose for the better CLBR, offering evidence-based references for clinicians. To determine the dose–response relationships of the factors and the optimal ranges of the factors in assisted reproductive technology (ART) associated with a higher CLBR, this study retrospectively analyzed 16,583 patients undergoing the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) from January 2017 to January 2019. Our study demonstrated the optimal ranges of age with a higher CLBR were under 32.10 years. We estimated the CLBR tends to increase with increased levels of AMH at AMH levels below 1.482 ng/mL, and the CLBR reaches a slightly high level at AMH levels in the range from 2.58–4.18 ng/mL. The optimal ranges of basal FSH with a higher CLBR were less than 9.13 IU. When the number of cryopreserved embryos was above 1.055 and the number of total transferred embryos was 2, the CLBR was significantly higher. In conclusion, there is a non-linear dose–response relationship between the CLBR with age, AMH, basal FSH, and the number of cryopreserved embryos and total transferred embryos. We proposed the optimal ranges of the five factors that were correlated with a higher CLBR in the first oocyte retrieval cycle, which may help consultation at IVF clinics.

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Section: Discussioncontrasting

confidence: 99%

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Wang

Zhang

et al. 2023

JCM

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“…Further observation revealed little difference after three cycles between conservative and optimistic CLBR. The report in the literature on CLBR was significantly different based on BMI and age; low CLBR was found with the age of ≥ 42 years and obesity 35 . In all the four groups, CLBR increased from cycle one subsequently to cycle three, meaning despite their infertility status, low prognosis women can increase their probability of conception by undergoing multiple cycles of IVF/ICSI.…”

Section: Discussionmentioning

confidence: 89%

“…It follows that, since POSEIDON criteria were introduced within the last decade, several publications have opted to assess different fertility outcomes among the four groups of low prognosis defined by the criteria 18,19 . With the majority assessing the cumulative probability of pregnancies 20,21 , a few assessed cumulative probabilities of pregnancy. However, to our knowledge, the long term perinatal and obstetric outcome is still unexplored among poor ovarian responders stratified by the criteria.…”

mentioning

confidence: 99%

Cumulative live-birth, perinatal and obstetric outcomes for POSEIDON groups after IVF/ICSI cycles: a single-center retrospective study

Abdullah

Liu

Zhao

et al. 2020

Sci Rep

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Recently, perinatal outcomes and cumulative live birth rate (cLBR) have widely been utilized to assess the fertility outcomes and safety of assisted reproductive technology (ARt), but more robust research is needed to address the success rates of live-healthy births resulting from this procedure, particularly for patients with low prognosis. this study aims to assess and comparative perinatal outcomes and cLBR per cycle of in vitro fertilization/intracytoplasmic sperm injection (iVf/icSi) between four groups of low prognosis characterized by poSeiDon criteria. A retrospective assessment was done among infertile women with a low prognosis undergoing iVf/icSi at a reproductive center in china. Data were collected between January 2011 and December 2015 with a follow-up of at least two years, and censoring was defined by three-cycle completion, discontinuation, or having a live birth. Participants were grouped into 4 groups according to the POSEIDON classification (POSEIDON1, POSEIDON2, POSEIDON3, and POSEIDON4). The main outcomes were perinatal and obstetric outcomes with cLBR per cycle after iVf/icSi procedure. And iVf/icSi-technique outcomes as a secondary outcome. Statistical analyses were performed by SpSS, and a p value of < 0.05 was considered significant. A total of 461 eligible participants underwent a total of 825 IVF/ICSI cycles. POSEIDON1 had the best perinatal outcomes in terms of live births (≥ 28w) (54.8%). POSEIDON4 had a higher risk for perinatal and obstetric complications with abortion rate (9.8%); LBW (11.7%), PTD (23.5%), PROM (11.7%), and gestational diabetes (17.6%). POSEIDON2 had a high rate for malpresentation (14.2%), and cesarean delivery(57.2%), while POSEIDON3 was much associated with the occurrences of placenta previa (9.3%) compared to other groups (p value = 0.001). After adjusting odds ratio by age and BMI, POSEIDON4 had the least odds for biochemical pregnancy (p value = 0.019); and the least odds for clinical pregnancy (p value = 0.001) of the four groups. CLBR per cycle was better in POSEIDON1 and increased with an increasing number of cycles in all groups during the three cycles. conservative cLBR after three complete cycles were 77.27%, 42.52%, 51.4% and 22.34%, while optimistic CLBR were 79.01%, 51.19%, 58.59% and 34.46% in POSEIDON1 to POSEIDON4, respectively. Younger women with low prognosis and normal ovarian reserve have a higher probability for live births and better perinatal outcomes compared with older women with poor or normal ovarian reserve. Besides, young women with low prognosis, despite ovarian reserve status, can increase their probability of conception and get relatively higher cLBR by undergoing multiple cycles of iVf/icSi. Age is therefore considered as a critical parameter in predicting the perinatal outcome and cLBR.

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“…However, In Vitro Fertilization (IVF) success remains lower than 100% and not satisfactory. Therefore, important indicators of decision making stand for the success probability and cost effectiveness as crucial to patients with a low ratio (7) . So, how to increase the favorable outcome of ART has become a critical topic for both clinicians and infertile couples.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Pregnancy Rate in Infertile Women Underwent in Vitro Fertilization / Intracytoplasmic Sperm Injection Cycle

Al-Jubouri¹,

Al-Obaidi²,

Hussaini³

2023

PJMHS

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Intracytoplasmic sperm injection is more being used for non-male factor indications, although it was developed for overcoming infertility of males because pregnancy rate of in vitro fertilization is still < 40%. This work aims at evaluating the vitro sperm injecting cycle fertilization/ Intracytoplasmic efficiency in infertile women and the factors that predicting clinical pregnancy rate. Al-Nahrain University at the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, we conducted a randomized clinical trial from 1st Sep. 2018 to 1st Sep. 2020. 40 women complaining from infertility underwent IVF / ICSI protocols were sampled for this work. Positive serum βhCG test were used to evaluate pregnancy r, two weeks following transferring embryo. In this study, 12 infertile women got pregnant with pregnancy rate of 30%. Duration of stimulation, number of mature eggs, fertilized eggs, and grade I transferred embryo, and changes in percentages in endometrial zone at day of pickup in comparison with that at day of hCG were significantly higher (P < 0.05) in pregnant women than those who were not pregnant. Failure rate of pregnancy is still high and the most important factors that associated with failure of IVF/ICSI outcome were short duration of gonadotropin stimulation, few number of mature eggs and embryos, and suboptimal endometrial receptivity. Keywords: IVF, ICSI, infertility, pregnancy rate, predictors, Iraq.

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Use of Cumulative Live Birth Rate per Total Number of Embryos to Calculate the Success of IVF in Consecutive IVF Cycles in Women Aged ≥35 Years

Cited by 10 publications

References 37 publications

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Association of the Cumulative Live Birth Rate with the Factors in Assisted Reproductive Technology: A Retrospective Study of 16,583 Women

Cumulative live-birth, perinatal and obstetric outcomes for POSEIDON groups after IVF/ICSI cycles: a single-center retrospective study

Factors Affecting Pregnancy Rate in Infertile Women Underwent in Vitro Fertilization / Intracytoplasmic Sperm Injection Cycle

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