Use of Contrasted Computerized Tomography as a Surrogate for Nuclear Medicine Renogram to Categorize Renal Function in the Setting of Ureteropelvic Junction Obstruction

Ark, Jacob; Mitchell, Christopher; Marien, Tracy; Herrell, S. Duke

doi:10.1016/j.urology.2016.04.068

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Moreover, DRF was easily and precisely evaluated using the equation from unenhanced CT. In 2016, Jacob et al (8) investigated 49 patients with UPJO and reported a strong correlation between percent cortical area multiplied by HU on CT and DRF of RG. Studies in 2014 by Hamed et al (10) and in 2012 by Sarma et al (14), including 42 and 21 patients, respectively, found that percent RPV on CT strongly correlated with DRF using 99mTc-DTPA renal scan.…”

Section: Discussionmentioning

confidence: 99%

“…Enhanced CT is prohibited in patients with worsening renal function ( 16 ) or allergy to contrast media. Furthermore, some studies ( 8 , 17 , 18 ) have applied HU to calculate CT-based DRF; however, it is difficult to standardize the data because tissue attenuation derived from enhanced CT is affected by a variety of factors ( 19 , 20 ), including contrast medium type, injection concentration and rate, and image acquisition time. However, these disadvantages do not apply in unenhanced CT.…”

Section: Discussionmentioning

confidence: 99%

“…RCMs were evaluated for their power of correlation to DRF. The percent RCM were calculated using the general format "100 * [Left RCM / (Left RCM + Right RCM)]" as previously reported (8,13). All percent RCMs used the left kidney, regardless of whether it was obstructed.…”

Section: Rcm Analysismentioning

confidence: 99%

“…Hence, exploring the relationship between renal CT measurements (RCM) and DRF has been an active area. Nevertheless, the results of previous research may not be applicable to the populations with upper urinary tract stones, given that previous studies primarily focused on patients with ureteropelvic junction obstruction (UPJO) or included heterogeneous population with a wide range of causes of stones (8,9). Furthermore, some studies may exposed patients to the risk for contrast nephropathy due to the use of iodinated contrast medium (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Estimation of Renal Function Using Unenhanced Computed Tomography in Upper Urinary Tract Stones Patients

Yang

Liu

et al. 2020

Front. Med.

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The aim of this study was to determine whether unenhanced computed tomography (CT) imaging can estimate differential renal function (DRF) in patients with chronic unilateral obstructive upper urinary tract stones. Materials and Methods: This was a single-center retrospective study of 76 patients. All the patients underwent unenhanced CT and nuclear renography (RG) at an interval of 4 to 6 weeks due to chronic unilateral obstructive urinary stones. Renal CT measurements (RCMs), including residual parenchymal volume (RPV) and volumetric CT texture analysis parameters, were obtained through a semiautomatic method. Percent RCMs were calculated and compared with renal function determined by RG. Results: The strongest Pearson coefficient between percent RCM and DRF was reflected by RPV (r = 0.957, P < 0.001). Combinations of RPV and other parameters did not significantly improve the correlation compared with RPV alone (r = 0.957 vs. r = 0.957, 0.957, 0.887, 0.815, and 0.956 for combination with Hounsfield unit, parenchymal voxel, skewness, kurtosis, and entropy, respectively; all P < 0.001). Percent RPV was subsequently introduced into linear regression, and the equation y = −2.66 + 1.07 * × (P < 0.001) was derived to calculate predicted DRF. No statistically difference was found between predicted DRF using the equation and observed DRF according to RG (P = 0.959). Conclusion: Unenhanced CT imaging can estimate DRF in patients with chronic unilateral obstructive upper urinary tract stones, and RG might not be necessary as a conventional method in clinical.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Rcm Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Estimation of Renal Function Using Unenhanced Computed Tomography in Upper Urinary Tract Stones Patients

Yang

Liu

et al. 2020

Front. Med.

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The Delayed Nephrogram: Point-of-care Quantitative Measurement, Validation as an Indicator of Obstruction, and Novel Use as a Predictor of Renal Functional Impairment

Strother

Cho

Loecher

et al. 2022

European Urology Focus

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A Technology of Renogram Dividing Based on Blood Vessels to Obtain a More Accurate Diagnosis

Kuo

Lee

et al. 2020

Biomed. Eng. Appl. Basis Commun.

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Nuclear medicine could provide an accurate estimate of the biochemical composition, metabolism, and capability of the kidney. Using nuclear medicine imaging to scan the organ, we can find the time-activity curve, called a renogram, by the intensity of the image. The activity curve can be employed to describe organ capability. Traditional methods of observing the activity curve of the whole kidney can obscure some small details. This paper proposes an improved renogram based on blood vessel distribution to estimate the kidney capability automatically. Every patient must acquire 180 renal dynamic images from the renal scan. First, acquiring region of the kidney in the No. 68 kidney image and correcting the background of this sample image, the sample image will be applied to the rest of the images to find the region of the kidney. The kidney image is then divided into several sub-regions according to the paths of the blood vessels from No. 50 kidney image. For each sub-region, we find the time–intensity curve, called the sub-renogram. Then, we observe the activity curves of the sub-region and the whole kidney separately to assist the diagnosis. The results of the automatic analysis are similar to the traditional methods used on the whole kidney, which ignores any abnormal sub-region activity. The proposed method can improve the accuracy of the doctor’s diagnosis.

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Use of Contrasted Computerized Tomography as a Surrogate for Nuclear Medicine Renogram to Categorize Renal Function in the Setting of Ureteropelvic Junction Obstruction

Cited by 3 publications

References 11 publications

Estimation of Renal Function Using Unenhanced Computed Tomography in Upper Urinary Tract Stones Patients

Estimation of Renal Function Using Unenhanced Computed Tomography in Upper Urinary Tract Stones Patients

The Delayed Nephrogram: Point-of-care Quantitative Measurement, Validation as an Indicator of Obstruction, and Novel Use as a Predictor of Renal Functional Impairment

A Technology of Renogram Dividing Based on Blood Vessels to Obtain a More Accurate Diagnosis

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