Use of Complementary/Integrative Nutritional Therapies during Cancer Treatment: Implications in Clinical Practice

Kumar, Nagi B.; Hopkins, Keandra; Allen, Kathy; Riccardi, Diane; Besterman-Dahan, Karen; Moyers, Susan

doi:10.1177/107327480200900307

Cited by 32 publications

(19 citation statements)

References 35 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further the anti-noise stressor activity of OS has already been reported for the central cholinergic system (Sembulingam et al, 2005). Kumar et al, (2002) reported that Indian Hypericum perforatum treatment (doses of 50 and 200 mg/kg) significantly decreased the levels of serotonin and its metabolite 5-hydroxy indole acetic acid and 5-HT turnover in all the brain regions (hypothalamus, hippocampus, striatum, ponsmedulla and frontal cortex). Moreover, they also reported that, it significantly augmented the levels of norepinephrine and its metabolite methylhydroxy phenyl glycol (MHPG) and norepinephrine turnover in all the brain regions studied.…”

Section: Discussionmentioning

confidence: 99%

Effect of Plumbago zeylanica administration on brain neurotransmitter level in Wistar albino rats

Baskaran¹,

Shanmugam²,

Raman³

2015

J App Pharm Sci

View full text Add to dashboard Cite

According to WHO about 80% of the world's population relies on traditional medicine for their primary health care. Plumbago zeylanica L. is a medicinal plant, belong to the family of Plumbaginaceae and the root of P. zeylanica contains several bioactive constituent like L-dopa, Plumbagin (naphthoquinone), droseron, chitranone, triterpenoid, anthraquinone. This study is designed to evaluate the effect of P. zeylanica and naphthoquinone on the level of various amine neurotransmitters namely epinephrine, norepinephrine, serotonin, 5-hydroxyindole 3-acetic acid (5-HIAA), and dopamine on the discrete regions of the brain tissues. Wistar male albino rats were treated separately with ethanoloic extract of P. zeylannica (root) and the commercially purchased phytochemical naphthoquinone at the dose of 2mg/kg b. wt with different experimental groups. The brain tissue homogenates (cerebral cortex, cerebellum, hypothalamus, pons-medulla, midbrain, and corpus striatum) were analyzed to quantify the aforementioned neurotransmitters by high performance liquid chromatography (HPLC). The results showed that, administration of P. zeylanica and NQ does not alter the many of the studied neurotransmitter at significant level; however, there is a change in the neurotransmitter profile in few specific regions of Wistar rat brain and striatum was found to be affected more.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Plumbago zeylanica administration on brain neurotransmitter level in Wistar albino rats

Baskaran¹,

Shanmugam²,

Raman³

2015

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Only 53% of the patients ceased using these products before surgery. Although the use of supplements in cancer patients is well documented, 3 there are no randomized clinical trials that have examined the effects of these supplements in the perioperative period.…”

mentioning

confidence: 99%

“…Many biologics and botanical supplements used by these patients have no proven efficacy in cancer treatment and may even interfere in traditional treatment modalities such as chemotherapy and radiation therapy if taken perioperatively. 3 Recent observations 3 and a growing body of literature have increased our understanding of the composition and function of these herbal supplements. As a result, serious concerns have been raised on the widespread use of herbal supplements among the presurgical population, which may have a negative impact on preoperative patient care.…”

mentioning

confidence: 99%

“…10 In a study of 820 cancer patients receiving chemotherapy or radiation therapy, 29.1% reported using complementary/integrative nutritional therapies that were not prescribed by their physician. 3 Of the 820 patients, 50.8% were men and 49.2% were women. Caucasians and patients over 60 years of age were predominant users of complementary/integrative therapies during treatment.…”

mentioning

confidence: 99%

“…1 The use of herbal supplements by cancer patients in the perioperative period is prevalent and consistent with the substantial increase in the use of alternative medical therapies by cancer patients. 3 Anywhere from 25% to 85% of cancer patients are seeking alternative and complementary nutritional therapies for prevention or during cancer treatment. The use of these therapies is highest among patients with breast cancer (80% to 85%), 4,5 pediatric cancer (46%), 6 prostate cancer (27% to 43%), [7][8][9] and head and neck cancer (25%).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Perioperative Herbal Supplement Use in Cancer Patients: Potential Implications and Recommendations for Presurgical Screening

2005

Self Cite

View full text Add to dashboard Cite

Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation

Dechêne¹,

Sowa²,

Gieseler³

et al. 2010

Hepatology

140

103

View full text Add to dashboard Cite

Acute liver failure (ALF) is associated with massive short-term cell death, whereas chronic liver injury is accompanied by continuous cell death. Hepatic stellate cells (HSCs) contribute to tissue repair and liver fibrosis in chronic liver injury, although their role in ALF remains unexplained. Twenty-nine patients (median age 5 43 years, 17 females and 12 males) with ALF according to the Acute Liver Failure Study Group criteria were included. Upon the diagnosis of ALF and after 7 days, we determined liver stiffness (LS) with FibroScan, standard laboratory parameters, and serum levels of matrix metalloproteinase 1 (MMP-1), MMP-2, MMP-9, tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2, hyaluronic acid, and markers of overall cell death (M65) and apoptosis (M30). Stellate cell activation and progenitor response were analyzed immunohistochemically in biopsy samples of 12 patients with a-smooth muscle actin (a-SMA), keratin-17, and keratin-19 staining, respectively. Cell death markers (M30 level 5 2243 6 559.6 U/L, M65 level 5 3732 6 839.9 U/L) and fibrosis markers (TIMP-1 level 5 629.9 6 69.4 U/mL, MMP-2 level 5 264 6 32.5 U/mL, hyaluronic acid level 5 438.5 6 69.3 lg/mL) were significantly increased in patients versus healthy controls. This was paralleled by collagen deposition, elevated a-SMA expression, and higher LS (25.6 6 3.0 kPa). ALF was associated with ductular progenitor proliferation. Conclusion: Our results demonstrate HSC activation and a progenitor response in ALF. Positive correlations between LS, the degree of liver cell damage, and the intensity of HSC activation suggest that fibrosis is a response to ALF in an attempt to repair damaged tissue. (HEPATOLOGY 2010;52:1008-1016 A cute liver failure (ALF) is a devastating clinical syndrome associated with high mortality in the absence of immediate state-of-the-art intensive care or liver transplantation. 1 ALF can occur as a result of various etiologies (overdosing with acetaminophen or other drugs, viral hepatitis, ischemia, and other causes 1 ); in approximately 15% of adult cases and 50% of pediatric cases, the reason is unidentified. 2

show abstract

Use of Complementary/Integrative Nutritional Therapies during Cancer Treatment: Implications in Clinical Practice

Abstract: A considerable proportion of cancer patients use unproven CINTs during cancer treatment. The health professional should become more aware of the complementary/integrative therapies that their patients are using during cancer treatment.

Cited by 32 publications

References 35 publications

Effect of Plumbago zeylanica administration on brain neurotransmitter level in Wistar albino rats

Effect of Plumbago zeylanica administration on brain neurotransmitter level in Wistar albino rats

Perioperative Herbal Supplement Use in Cancer Patients: Potential Implications and Recommendations for Presurgical Screening

Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation

Contact Info

Product

Resources

About