The increased incidence of cancer is one of the serious health problems related to climate change. The deterioration of the environment becomes one of the risk factors for cancer. In respond to that problem, the Indonesian health system makes a breakthrough to strengthen health resilience by encouraging the use of Indonesian plant medicine in adjunct with standard pharmaceutical therapy for cancer. The study aimed to investigate the potential of Indonesian plant medicine for the development of complementary medicine for cancer.This review is based on the original paper published on the last five years. The search found several Indonesian plant with high potency for anti-cancer activity, based on in vitro and in vivo study. The medicinal plant include Curcuma longa, Annona muricata, Morinda citrifolia, Elephantopus scaber, Zanthoxylum acanthopodium DC, and Caesalpinia sappan.