Use of collagen shields for ocular-surface drug delivery

Greenwald, Yoel; Kleinmann, Guy

doi:10.1586/17469899.3.6.627

Cited by 11 publications

(3 citation statements)

References 33 publications

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“…In eye, collagen shield encapsulated or physically absorbed with drug molecules can sustain for maximum 3 days prior to complete degradation 147 . Collagen shields has been used for various ocular applications including antibacterial 148 149 , antiinflammatory 150 , anti-coagulant 151 , anti-fungal 152 , immunosuppressive 153 , steroidal 154 of for glaucoma treatment 145 . The ZnO/PVP nanoparticles were used for the crosslinking agent with 1:1 of collagen, and fabricated collagen shield exhibited sustained release for 14 days.…”

Section: Collagenmentioning

confidence: 99%

Recent advances in drug delivery systems for glaucoma treatment

Patel

Silva

Park

et al. 2022

Materials Today Nano

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Section: Collagenmentioning

confidence: 99%

Recent advances in drug delivery systems for glaucoma treatment

Patel

Silva

Park

et al. 2022

Materials Today Nano

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“…It is important to keep in mind that visual acuity is impaired by the presence of a corneal shield. The use of collagen corneal shields for ocular drug delivery has been reviewed recently by Greenwald and Kleinmann [85].…”

Section: Nonimplantablementioning

confidence: 99%

Drug delivery systems for the eye

Kearns

Williams

2009

Expert Review of Medical Devices

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Topical and systemic administration of drugs to the eye is highly inefficient and there is a need for controlled, sustained release, particularly for conditions that affect the posterior segment. Various nonimplantable and implantable drug delivery devices have been developed. Colloidal carriers may allow targeted drug delivery and afford protection to substances that are sensitive to degradation, particularly RNA/DNA-based treatments. Gene therapy and cell transplantation are also starting to emerge as alternatives to conventional pharmacological treatment. There is the potential to use existing ocular devices to deliver drugs. In order to exploit this opportunity, modifications to drugs and devices, along with clarification of the appropriate drug dose, must be undertaken. This review will describe some of the treatment options for ocular disease and barriers to drug delivery, discuss the design of existing drug delivery systems and highlight some of the research into combining drug delivery with existing ocular medical devices.

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“…Waste from the fishing industry: skin, fins, tail contains collagen [1,2]. Materials based on fish collagen have a number of advantages compared to the analogue of animal origin: first of all, it is a greater structural similarity with human collagen, providing a higher level of biocompatibility [1,[3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of grafted polybutyl acrylate copolymer on fish collagen

Uromicheva

Kuznetsova

Valetova

et al. 2021

Izvestiâ vuzov. Prikladnaâ himiâ i biotehnologiâ

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Increasingly, scientists are turning to the study of marine, or fish, collagen, which is increasingly replacing collagen of terrestrial animals, due to the fact that it is hypoallergenic, since it is 96% identical to human protein. Materials based on fish collagen have a number of advantages over their analogue of animal origin: it is not a carrier of infectious diseases of animals transmitted to humans, it has a greater structural similarity to human collagen, which provides a higher level of biocompatibility. Materials based on collagen copolymers with synthetic monomers are promising. The use of hybrid materials also helps to reduce the consumption of non-renewable natural resources. Synthesis of grafted collagen copolymers with polybutyl acrylate was carried out at azobisisobutyronitrile initiation and triethyl borane – oxygen system initiation under comparable conditions under intensive stirring of aqueous solution dispersion of collagen and butyl acrylate. After the synthesis, the aqueous and organic phases of the reaction mixture were analyzed by composition and molecular weight parameters using infrared spectroscopy and size-exclusion chromatography. Changes indicating the formation of a copolymer are observed in the copolymer isolated from the aqueous phase, more pronounced in the triethyl borane – oxygen system. It is assumed that the formation of copolymer macromolecules for azobisisobutyronitrile and organoelement initiator takes place according to different schemes. Schemes for the formation of copolymer macromolecules for AIBN and an organoelement initiator are proposed. Only polybutyl acrylate is present in the organic phase. Biological studies were carried out for fungal resistance and bactericidal activity of the obtained copolymers.

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Use of collagen shields for ocular-surface drug delivery

Cited by 11 publications

References 33 publications

Recent advances in drug delivery systems for glaucoma treatment

Recent advances in drug delivery systems for glaucoma treatment

Drug delivery systems for the eye

Synthesis of grafted polybutyl acrylate copolymer on fish collagen

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