Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient

Gonzalez, Anthony

doi:10.1097/won.0000000000000231

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…In vivo studies have demonstrated that OFM is anti-inflammatory [24], stimulates angiogenesis [25] and is remodeled over time [26]. Clinically, OFM has found a range of applications in soft tissue repair, including wound healing [27][28][29][30][31][32][33], reconstructive surgery [34], and abdominal wall repair [35]. Given that dECM biomaterials contain a milieu of growth factor binding proteins, cytokines and growth factors, it is not surprising these biomaterials recruit MSCs in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo

et al. 2020

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Soft tissue is composed of cells surrounded by an extracellular matrix that is made up of a diverse array of intricately organized proteins. These distinct components work in concert to maintain homeostasis and respond to tissue damage. During tissue repair, extracellular matrix proteins and their degradation products are known to influence physiological processes such as angiogenesis and inflammation. In this study we developed a discovery platform using a decellularized extracellular matrix biomaterial to identify new chemotrophic factors derived from the extracellular matrix. An in vitro culture of RAW.264 macrophage cells with the biomaterial ovine forestomach matrix led to the identification of a novel~12 kDa chemotactic factor, termed 'MayDay', derived from the N-terminal 31-188 sequence of decorin. The recombinant MayDay protein was shown to be a chemotactic agent for mesenchymal stromal cells in vitro and in vivo. We hypothesize that the macrophage-induced cleavage of decorin, via MMP-12, leads to the release of the chemotactic molecule MayDay, that in turn recruits cells to the site of damaged tissue.

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Section: Introductionmentioning

confidence: 99%

A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo

et al. 2020

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“…There is a growing body of evidence to support the use of OFM in healing a variety of wound types. 22 , 23 , 24 , 25 , 26 , 27 , 28 However, to the authors' knowledge there has not been a large, retrospective RWD study of OFM making comparisons to a reconstituted collagen product. In this instance we selected collagen/ORC for the comparison given the products long‐established use in wound care.…”

Section: Discussionmentioning

confidence: 99%

“…There is a growing body of evidence to support the use of OFM in healing a variety of wound types 22‐28 . However, to the authors' knowledge there has not been a large, retrospective RWD study of OFM making comparisons to a reconstituted collagen product.…”

Section: Discussionmentioning

confidence: 99%

Retrospective real‐world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers

Bosque¹,

Frampton

Chaffin

et al. 2021

International Wound Journal

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The retrospective pragmatic real‐world data (RWD) study compared the healing outcomes of diabetic foot ulcers (DFUs) treated with either ovine forestomach matrix (OFM) (n = 1150) or collagen/oxidised regenerated cellulose (ORC) (n = 1072) in out‐patient wound care centres. Median time to wound closure was significantly (P = .0015) faster in the OFM group (14.6 ± 0.5 weeks) relative to the collagen/ORC group (16.4 ± 0.7). A sub‐group analysis was performed to understand the relative efficacy in DFUs requiring longer periods of treatment and showed that DFUs treated with OFM healed up to 5.3 weeks faster in these challenging wounds. The percentage of wounds closed at 36 weeks was significantly improved in OFM treated DFUs relative to the collagen/ORC. A Cox proportional hazards analysis showed OFM‐treated wounds had a 18% greater probability of healing versus wounds managed with collagen/ORC, and the probability increased to 21% when the analysis was adjusted for multiple variables. This study represents the first large retrospective RWD analysis comparing OFM and collagen/ORC and supports the clinical efficacy of OFM in the treatment of DFUs.

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“…Collagen can interact with a various regenerative process that ranges from angiogenesis to re epithelialization in wound healing [ it is used in different scaffolds to enhance the wound healing process. Collagen was first utilized as a modern biomaterial in 1881 by Joseph Lister and William Macewan obtained from a sheep's small intestine [ Since then, collagen biomaterial as dressing has evolved countless times until today, where it flavoured numerous types of wounds with a faster healing rate [21,22]. Its biocompatibility with tissues, biodegradability and non nature are among the advantages conferred by the collagen dressing [7].…”

Section: Fig 4 Collagen Based Wound Dressing Product Applicationmentioning

confidence: 99%

Bovine Based Collagen Dressings in Wound Care Management

Santhanam

Rameli

Jeffri³

et al. 2020

JPRI

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Collagen plays a significant role in treating acute and chronic wounds such as cuts, burns, ulcers associated with other illness via enhancing the debridement of infected tissues, angiogenesis and promoting natural growth. There are several types of collagen, which can be obtained from various animal sources such as chicken, bovine, porcine, fish etc. Among that bovine based collagen contributed many shares towards biomedical application. Nowadays using bovine based collagen biomaterials for wound care is in trend to minimize the negative impacts such as infection, pain and other side effects. However, its applicable and effectiveness are not fully revealed. At the same time, clinicians and researchers are exploring and implementing advanced techniques and treatment procedures to reduce the wound healing burden effectively. In this review, we aimed to focus on the fundamental information about types of wound dressings, collagen dressings and the clinical utility of bovine based collagen dressings in providing essential knowledge in advanced wound care management.

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Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient

Cited by 10 publications

References 11 publications

A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo

A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo

Retrospective real‐world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers

Bovine Based Collagen Dressings in Wound Care Management

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