Use of coconut coir fibers as an inert solid support for production of cyclosporin A

Abstract

In the present study, coconut coir was evaluated as an inert support for the production of cyclosporin A (CyA) using=qçäóJ éçÅä~Çáìã= áåÑä~íìã MTCC 557 by solid state fermentation. Initially, four different inert supports such as coconut coir, polyurethane foam, polystyrene beads, and sugarcane baggase were screened using different production media as moistening agents for the maximum production of CyA. Different parameters such as fermentation time, carbon sources, moisture content, pH, and inoculum size were optimized. It was observed that coconut coir impregnated with medium modified with glycerol as carbon source, pH 6, at 80% moisture content, and inoculum size of 2.5 mL/2.5 g support produced 2641 mg/kg of CyA after 12 days as compared to 998 mg/kg before optimization. The yields were further increased to 3597 mg/kg substrate with addition of combination of amino acids after 48 h of fermentation. © KSBB hÉóïçêÇëW=~ÅíáåçãóÅáå=áåÉêí=ëìééçêíI=ÅçÅçåìí=ÅçáêI=ÅóÅäçëéçêáå=^I=Tolypocladium inflatum= = = = =

Experimental Study of the Drying Kinetics of the Coconut Shells (Nucifera) of Cameroon

“…The humid mass m 0 and the equilibrium mass m eq allowed the calculation of the water content of each of the samples tested using Equation (1). The Table 3 shows the median values and the standard deviations obtained from 20 samples tested per species.…”

“…Although the by-products of the coconuts tree are for the most part thrown away into our environment, thus causing pollution, the populations look non-stop for ways to use them. It is thus the fibers of the trunk and the CS that are exploited in the elaboration of composites [1]; the CS is used in the elaboration of active carbon [2], in decoration, in kitchen utensils and in art objects. Outside of this, a non-negligible quantity of the CS is thrown away into our immediate environment.…”

Produção de enzimas fúngicas hidrolíticas para obtenção de amino-oligossacarídeos

“…Dentre as alternativas tecnológicas no setor de produção de enzimas industriais destaca-se a FES por apresentar alta produtividade, simplicidade de operação, formação de produtos concentrados e condição menos favorável a contaminação quando comparada com fermentações submersas, além de possibilitar o uso de resíduos de origem vegetal e animal como substratos de baixo custo (SURVASE et al, 2009;MAZUMDER et al, 2009). FES é definida como o crescimento de microrganismos em meio isento de água livre.…”

“…A seleção de um substrato sólido adequado desempenha um papel importante no desenvolvimento de um eficiente processo de FES. O tamanho da partícula, composição química dos substratos, custo e disponibilidade são considerações importantes (SURVASE et al, 2009;VISHWANATHA et al, 2010;COUTO, 2008).…”