Use of Clonidine in the Management of Patients with Neurogenic Bladder
Dysfunction

Rao, M.S.; Vaidyanathan, S.; Chary, K.S.N.

doi:10.1159/000473349

Cited by 8 publications

(2 citation statements)

References 8 publications

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“…This includes, inter alia, migraine, tardive dyskinesia [54] , essential tremor [55] , neurogenic bladder [56] , idiopathic orthostatic hypotension, paroxysmal localized hyperhidrosis [57] , diabetic neuropathy [58] and stiff-man syndrome [59] .…”

Section: Other Usesmentioning

confidence: 99%

Clonidine Use in Psychiatry: Panacea or Panache?

Naguy¹

2016

Pharmacology

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Clonidine, an alpha agonist, formally prescribed in clinical medicine as antihypertensive medication, is currently being used more frequently to address a multitude of psychiatric entities. The long-acting formulation is approved by the Food and Drug Administration for use in treating the attention-deficit/hyperactivity disorder. In addition to this only legitimate indication, it has long been used successfully for opiate detoxification, post-traumatic stress disorder and de la Tourette syndrome. Moreover, clonidine helps in the treatment of neuroleptic-induced akathisia, stimulant-induced insomnia and clozapine-induced sialorrhea. It has been tried in treating menopausal syndrome and psychogenic polydipsia. Although the strength of evidence supporting the use of clonidine in such clinical scenarios is highly variable and oscillating, from strong to only flimsy, this overview is intended to shed some light on the clonidine portfolio as a potential and attractive addition to the psychopharmacologic armamentarium.

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Section: Other Usesmentioning

confidence: 99%

Clonidine Use in Psychiatry: Panacea or Panache?

Naguy¹

2016

Pharmacology

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“…Clonidine and phenoxybenzamine diminished Pura and the EMG activity of the rhabdosphincter; phentolamine diminished Pura but had no effect on the EMG sphinteric activity. Rao et al [1980] showed that clonidine diminished Pura in patients with neurogenic bladder disfunction. Pedersen [Pedersen, 1980;Pedersen et al, 1978,19801 injected intravenous and intra-arterial thymoxamine (an alphaadrenergic blocking agent that crosses the BBB) in paraplegic patients and suggested a central relaxation of the spastic external sphincter.…”

Section: Neurourodynamicsmentioning

confidence: 99%

Urodynamic action of clonidine in the chronic spinal cat

Galeano

Jubelin

Carmel

et al. 1986

Neurourology and Urodynamics

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Spinalization produces a central micturition dysreflexia characterized by weak vesical contraction reflexes and by an exaggerated urethro-urethral contraction reflex, causing the peripheral syndromes of underactive detrusor and detrusor-sphincter dys-synergia. We explored the action of catecholaminergic drugs of central action on these micturitional dysfunctions.Twenty-four male cats were spinalized by transection of the spinal cord at C S C 6 level and studied 1-18 weeks later. Cystosphincterograms were performed without using anesthetic drugs. Pves, Pura, the EMG of the external sphincter, the EMG of the extensor hindleg muscles, and urine emission were studied. The responses of the spinal vesicovesical contraction, urethro-vesical contraction, and urethro-urethral contraction reflexes were explored. Clonidine (0.02-0.06 mg/kg intravenously [IV] , intraperitoneally [IP], or per os), phentolamine (0.7-1 mg/kg, IV), and yohimbine (0.4-1 mg/kg, IV) were administered.Clonidine, at doses of 0.02 mg/kg, IV or IP, or higher, produced the following effects: (1) it significantly increased the intensity and duration of Pves waves; (2) it inhibited the spasms of the external sphincter; (3) it induced voiding; (4) it reduced spasticity; (5) it reinforced the vesico-vesical contraction reflex; (6) it antagonized the exaggeration of the urethro-urethral contraction reflex; (7) it corrected totally or partially the underactive detrusor and detrusor-sphincter dys-synergia. Taken orally (0.02-0.03 mg/kg) the urodynamic effect of clonidine was not significant; higher doses produced vomiting and other adverse effects. The action of clonidine was blocked by yohimbine but not by phentolamine.These results suggest that the absence of the descending noradrenergic pathways plays a role in the physiopathology of neurogenic bladder dysfunctions in chronic spinalized cats.

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Sonstige Indikationen von Clonidin. Clonidin: Forschungsinstrument und Therapeutikum

Görlich

1983

Zentrale Blutdruckregulation Durch Α 2-Rezeptorenstimulation

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Use of Clonidine in the Management of Patients with Neurogenic Bladder Dysfunction

Cited by 8 publications

References 8 publications

Clonidine Use in Psychiatry: Panacea or Panache?

Clonidine Use in Psychiatry: Panacea or Panache?

Urodynamic action of clonidine in the chronic spinal cat

Sonstige Indikationen von Clonidin. Clonidin: Forschungsinstrument und Therapeutikum

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