Use of Clinical Tools and Tests in Sleep Medicine

Goldstein, Cathy; Chervin, Ronald D.

doi:10.1016/b978-0-323-24288-2.00060-x

Cited by 4 publications

(2 citation statements)

References 150 publications

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“…PSG is a typical application of long-term biopotential recording that can monitor sleep status overnight and classify different sleep stages. PSG can be used to diagnose dozens of sleep disorders, and is the gold standard for obstructive sleep apnea hypopnea syndrome (OSAHS) diagnosis [ 52 ]. Sleep staging based on biopotentials is the key to interpreting sleep.…”

Section: Resultsmentioning

confidence: 99%

High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography

Huang

et al. 2022

Nano-Micro Lett.

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Highlights Polyimide-based flexible microneedle array (PI-MNA) electrodes realize high electrical/mechanical performance and are compatible with wearable wireless recording systems. The normalized electrode–skin interface impedance (EII) of the PI-MNA electrodes reaches 0.98 kΩ cm2 at 1 kHz and 1.50 kΩ cm2 at 10 Hz, approximately 1/250 of clinical standard electrodes. This is the first report on the clinical study of microneedle electrodes. The PI-MNA electrodes are applied to clinical long-term continuous monitoring for polysomnography. Abstract Microneedle array (MNA) electrodes are an effective solution to achieve high-quality surface biopotential recording without the coordination of conductive gel and are thus very suitable for long-term wearable applications. Existing schemes are limited by flexibility, biosafety, and manufacturing costs, which create large barriers for wider applications. Here, we present a novel flexible MNA electrode that can simultaneously achieve flexibility of the substrate to fit a curved body surface, robustness of microneedles to penetrate the skin without fracture, and a simplified process to allow mass production. The compatibility with wearable wireless systems and the short preparation time of the electrodes significantly improves the comfort and convenience of electrophysiological recording. The normalized electrode–skin contact impedance reaches 0.98 kΩ cm2 at 1 kHz and 1.50 kΩ cm2 at 10 Hz, a record low value compared to previous reports and approximately 1/250 of the standard electrodes. The morphology, biosafety, and electrical/mechanical properties are fully characterized, and wearable recordings with a high signal-to-noise ratio and low motion artifacts are realized. The first reported clinical study of microneedle electrodes for surface electrophysiological monitoring was conducted in tens of healthy and sleep-disordered subjects with 44 nights of recording (over 8 h per night), providing substantial evidence that the electrodes can be leveraged to substitute for clinical standard electrodes.

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Section: Resultsmentioning

confidence: 99%

High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography

Huang

et al. 2022

Nano-Micro Lett.

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“…It was discovered in the 1970s. It received FDA approval in 1993 and has been available generically in the USA since 2004 . Gabapentin is approved for use in the United Kingdom (U.K.) to treat various conditions, including focal seizures, peripheral neuropathic pain, menopausal symptoms in women with breast cancer, oscillopsia and spasticity in multiple sclerosis, as well as muscular symptoms in motor neurone disease .…”

Section: Mechanism Of Action Of Antiepileptic Drugsmentioning

confidence: 99%

Anticonvulsant Classes and Possible Mechanism of Actions

Abd-Allah,

El-Mohsen Anwar,

Mohammed

et al. 2023

ACS Chem. Neurosci.

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Epilepsy is considered one of the most common neurological disorders worldwide; it needs long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs, approximately 30% patients still suffer from drug-resistant epilepsy. Subsequently, searching for new anticonvulsants with lower toxicity and better efficacy is still in paramount demand. Using target-based studies in the discovery of novel antiepileptics is uncommon owing to the insufficient information on the molecular pathway of epilepsy and complex mode of action for most of known antiepileptic drugs. In this review, we investigated the properties of anticonvulsants, types of epileptic seizures, and mechanism of action for anticonvulsants.

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Contemporary Concepts in the Diagnosis and Management of Obstructive Sleep Apnea

Arumugam

2021

Advances in Medical Technologies and Clinical Practice

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Optimal sleep is an inseparable component of both physical and psychological well-being. With the widespread increase in the prevalence of sleep disorders, there has been an immense interest among the global researchers in exploring the molecular biology of sleep and innovative modalities for diagnosing and treating sleep disorders. Notably, sleep disorders encompass a wide spectrum of sleep disturbances with potential multisystem complications. Polysomnography is an overnight sleep study that is widely considered as the gold standard objective diagnostic method for diagnosing obstructive sleep apnea (OSA) and provision of continuous positive airway pressure (CPAP), which maintains airway patency during sleep remains the cornerstone therapy for OSA. Although CPAP remains the mainstay of therapy for OSA, various oral appliances and surgical interventions have widely been considered for OSA. This chapter provides a comprehensive overview of contemporary diagnostic and therapeutic approaches available in clinical practice for sleep-related breathing disorders with particular emphasis on OSA.

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Use of Clinical Tools and Tests in Sleep Medicine

Cited by 4 publications

References 150 publications

High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography

High-Performance Flexible Microneedle Array as a Low-Impedance Surface Biopotential Dry Electrode for Wearable Electrophysiological Recording and Polysomnography

Anticonvulsant Classes and Possible Mechanism of Actions

Contemporary Concepts in the Diagnosis and Management of Obstructive Sleep Apnea

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