Use of cis-atracurium to maintain moderate neuromuscular blockade in experimental pigs

Tutunaru, Alexandru-Cosmin; Dupont, Julien; Huberty, Vincent; Ibrahim, Mostafa; Serteyn, Didier; Sandersen, Charlotte

doi:10.1016/j.vaa.2016.09.006

Cited by 6 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, doses of 1 mg/kg cis‐atracurium were needed to achieve a complete decrease in the TOF count and TOFR in the pigs. Compared to other cis‐atracurium studies in the pig, where the neuromuscular blockade end‐point was to achieve a decrease in TOF count to ≤2 twitches, the dose administered in the present study was up to three times higher (Tutunaru et al., ). These high doses may increase the possibility that cis‐atracurium acts on M2 receptors and affects cardiovascular values.…”

Section: Discussionmentioning

confidence: 71%

See 1 more Smart Citation

Neuromuscular block monitoring after the administration of 1 mg/kg intravenous cis‐atracurium in the anaesthetized pig

Aguilar

Moll

García

et al. 2018

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Neuromuscular blocking agents should be included as part of a balanced anaesthetic protocol to improve anaesthetic management, although doses are not always established for each species. Cis-atracurium is a benzylisoquinolinium neuromuscular blocking agent with an intermediate duration of action devoid of significant adverse effects previously used in pigs with a wide dosage range. Cis-atracurium was administered at 1 mg/kg bolus to sixteen pigs to establish its time profile and effects. The pigs were premedicated intramuscularly with 4 mg/kg azaperone, 8 mg/kg ketamine and 0.2 mg/kg morphine IM and maintained with isoflurane in oxygen. After cis-atracurium administration, neuromuscular monitoring via acceleromyography was started until the recovery of the 90% of the train of four ratio. Complete decrease in the train of four ratio was accomplished in eleven pigs. Onset of action was 70 s, with a recovery of the fourth twitch at 26 min and a recovery of a train of four ratio greater than 90% in 60 min. In conclusion, 1 mg/kg intravenous cis-atracurium in the pig allowed for a rapid onset of action and a complete recovery after 60 min although high variability in the time profile is seen.

show abstract

Section: Discussionmentioning

confidence: 71%

“…This monitoring site allowed for repeatable measurements without the possibility of inadvertent movements of the limb as it was fixed in a box. However, other monitoring sites have been described in the pig, such as the peroneal nerve (Tutunaru et al., ).…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular block monitoring after the administration of 1 mg/kg intravenous cis‐atracurium in the anaesthetized pig

Aguilar

Moll

García

et al. 2018

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

show abstract

“…Anesthesia was induced with an intramuscular cocktail of atropine 0.04 mg/kg, butophanol 0.05–0.1 mg/kg, esketamine 10–15 mg/kg, and midazolam 0.4 mg/kg ( 5 ). Animals were intubated using 6.0–7.5 mm endotracheal tube, followed by sevoflurane (2%–3%), cis-atracurium 0.5 mg/kg/h, and sufentanil 0.3 μg/kg/h for anesthesia maintenance ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

Resuscitative Rectal Balloon Compression Combined With Pelvic Binder Efficiently Controlled Fatal Venous Hemorrhage in a Hemodynamically Unstable Pelvic Fracture Canine Model

Chu

Jin

Bing

et al. 2023

Shock

View full text Add to dashboard Cite

Objective: This study evaluated the feasibility of a combination of pelvic binder and rectal balloon compression in managing fatal venous hemorrhage in a canine model of pelvic fracture. Methods: Rectums from humans (rectal cancer patients), swine, and canines were retrieved to determine their elasticity by measuring their stress and strain. Canines were selected as the animal model in this study because their rectum demonstrated more reversible strain than swine rectum. Doppler ultrasound was used to assess the effect of rectal balloon volume on the blood flow of pelvic iliac blood vessels in three canines. A rectal balloon of 250 mL was chosen to control pelvic venous bleeding as it could provide a peak effect in reducing the blood flow of bilateral internal iliac veins. Then, the open-book pelvic fracture with fatal bleeding of both internal iliac veins animal model was built. The animals were divided into four groups after the modeled surgery to undergo no treatment, pelvic binder, rectal balloon compression, or a combination of pelvic binder and rectal balloon compression. The treatment efficacy was evaluated based on their survival time, survival rate, blood loss, bleeding rate, infusion rate, blood pH, lactate concentration, the stability of hemodynamics, blood loss, and fluid infusion volume. Results: Our results showed that after the reproducible injuries in both internal iliac veins, the combination of pelvic binder and rectal balloon compression was associated with the best survival rate and survival time compared with the other treatment groups. In addition, the combination of pelvic binder and rectal balloon compression exhibited more stable hemodynamics than the pelvic binder or rectal balloon compression treatment alone. Conclusions: This study demonstrated the potential feasibility of using pelvic binder combined with rectal balloon compression to manage the fatal venous bleeding in pelvic fractures.

show abstract

“…Many other NMBAs have already been studied in horses [1] and the use of cis-atracurium is documented in dogs and pigs [2,3]. To the authors’ knowledge, there is no study on the clinical use of cis-atracurium published in this species.…”

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of clinical use of cis-atracurium in horses

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background To the authors’ knowledge, there are no reports describing the use of cis-atracurium in the horse. Objective To describe the onset time and the duration of the neuromuscular blockade (NMB) of three different doses of cis-atracurium in horses and to determine the appropriate dose needed maintain a NMB. Study design Retrospective study. Methods Horses which received cis-atracurium as part of a balanced anaesthetic protocol at the Equine Teaching Hospital of the University of Liège between March 2014 and June 2017 were included in this study. A train-of-four (TOF) stimulation pattern was used to assess the NMB. The cis-atracurium induction dose, the onset and duration of action (when TOF count was under three twitches) of the first bolus, the number of supplementary boluses of cis-atracurium and the total dose of cis-atracurium administered per horse, the total duration of the NMB and the recovery time were recorded and analysed. Also the use of an antidote and any side effects produced by cis-atracurium were recorded. Results From 37 horses that received cis-atracurium during this period, only 23 had a complete records and were included in the study. Three different doses of cis-atracurium were used to induce NMB: 100 μg/kg ( n = 8) 75 μg/kg ( n = 3) and 50 μg/kg ( n = 12). Cis-atracurium 50 μg/kg failed to induce NMB in 3 horses. The onset of action was not significantly different between the three doses (5 minutes). The duration of the NMB was dose-dependent. The calculated dose of cis-atracurium necessary to maintain a NMB was 2.3 μg/kg/minute based on the sum of the induction dose and the supplementary boluses divided by the duration of the NMB. Main limitations A further prospective study is needed to confirm the results. Conclusions Cis-atracurium can be an alternative to other NMBA in horses.

show abstract

Use of cis-atracurium to maintain moderate neuromuscular blockade in experimental pigs

Cited by 6 publications

References 7 publications

Neuromuscular block monitoring after the administration of 1 mg/kg intravenous cis‐atracurium in the anaesthetized pig

Neuromuscular block monitoring after the administration of 1 mg/kg intravenous cis‐atracurium in the anaesthetized pig

Resuscitative Rectal Balloon Compression Combined With Pelvic Binder Efficiently Controlled Fatal Venous Hemorrhage in a Hemodynamically Unstable Pelvic Fracture Canine Model

Retrospective evaluation of clinical use of cis-atracurium in horses

Contact Info

Product

Resources

About