Use of Chlorpromazine in Two Hundred Seventy-Eight Mentally Deficient Patients

Antipsychotics and Autism: Weight, Metabolism, and Safety

“…Trials reviewing safety and efficacy of other first-generation antipsychotics, such as trifluoperazine (Fish et al, 1966), fluphenazine (Faretra et al, 1970), chlorpromazine (Tarjan et al, 1957), and pimozide (Naruse et al, 1982) all revealed overall improvement in stereotypy, social withdrawal, irritability, and verbal communication over placebo, with similar side effect profile to haloperidol.…”

Neuroleptics and Epilepsy in Mentally Handicapped Patients

“…Bonafede (1955) reported an increase in fits in two out of 26 patients with epilepsy, most of whom were mentally handicapped, after being prescribed 200-300 mg of chlorpromazine daily. Tarjan, Lowery & Wright (1957) found an increase in fits in 12 out of 82 mentally handicapped patients with epilepsy given 25-700 mg of chlorpromazine daily. On the other hand, Baldwin & Kenny (1966) reported a reduction in the frequency of fits in six out of 33 children, many of whom were mentally handicapped, when prescribed thioridazine 15-200 mg daily, and Carter (1959) found a reduction in the frequency and severity of seizures amongst 'emotionally disturbed' mentally handicapped children given 30-600 mg of prochlorperazine daily.…”

Efficacy of Neuroleptic Medication in Pervasive Developmental Disorders of Childhood

“…The child with seizures presents a difficult problem. There have been several reports of chlorpromazine lowering the seizure threshold in epileptic children (Fabisch 1955;Hunt, Frank, and Krush 1956;Tarjan, Lowery, and Wright 1957), and it would therefore seem advisable to avoid its use in children with seizure disorders. Similar, but less welldocumented findings have also been reported for fluphenazine (Arnold and Magin 1967) and trifluoperazine (Engelhardt, Polizos, and Margolis 1972).…”