Use of chloro-aluminum sulfonated phthalocyanine as a photosensitizer in the treatment of malignant tumors in dogs and cats

Peavy, George M.; Klein, Mary K.; Newman, H. C.; Roberts, W. Gregory; Berns, Michael W.

doi:10.1117/12.44004

Cited by 5 publications

(6 citation statements)

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“…It is obviously that the time constant of 810 fs, which is markedly larger, must reflect a different pathway of energy dissipation of AlPcS 4 in cancerous tissue. It is well known that the phthalocyanine-based photosensitizers are effective in photodynamic therapy − when the excited molecule transfers its excess energy to the ground state of the molecular oxygen 3 O 2 producing the excited-state singlet oxygen 1 O 2 . In this reaction (called Type II reaction) the photosensitizer goes through intersystem crossing from the excited-state S 1 to the triplet-state T 1 followed by regeneration of ground-state S 0 .…”

Section: Discussionmentioning

confidence: 99%

“…Phthalocyanines are promising materials in medicine, electronics, opto-electronics, electrochemistry, and catalysis. The growing numbers of phthalocyanines play an important role as photosensitizers in photodynamic therapy (PDT), inactivation of antibiotic-resistant microorganisms, − and as materials in low-gap semiconducting electronic devices . Localization, tumor affinity, and phototoxicity of photosensitizers are known to be determined by vascular permeability and interstitial diffusion, which depend on many factors such as molecular size, configuration, charge, and hydrophilic or lipophilic properties .…”

Section: Introductionmentioning

confidence: 99%

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Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

et al. 2013

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A promising material in medicine, electronics, opto electronics, electrochemistry, catalysis, and photophysics, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS 4 ) is investigated at biological interfaces of human breast tissue by means of steady state and time resolved pump−probe spectroscopies: IR, Raman, UV−vis, fluorescence, and electronic transient absorption by pump−probe spectroscopy. Spectrally resolved pump−probe data were recorded on time scales ranging from femtoseconds to nanoseconds and give insight into molecular interactions and primary events in the interfacial region. The nature of these fast processes and pathways of the competing relaxation processes from the initially excited electronic states in AlPcS 4 films and at biological interfaces of human breast cancerous and noncancerous tissues is studied. Comparison between photochemical dynamics in the biological environment of the human breast tissues and that occurring in aqueous solutions is presented. The excited state absorption (ESA) decays and bleaching recovery of the ground state have been fitted in the time window extending to nanoseconds (0−1 ns). We found that the excited state dynamics of AlPcS 4 at biological interfaces of human breast tissue is extremely sensitive to the biological environment and differs drastically from that observed in solutions and films. We demonstrated that the ultrafast dynamics at biological interfaces is described by three time constants in the ranges of 110−170 fs, 1−7 ps, and 20−60 ps. We were able to ascribe these three time constants to the primary events occurring in phthalocyanine at biological interfaces. The shortest time constants have been assigned to vibrational wavepacket dynamics in the Franck−Condon region down to the local minimum of the excited state S 1 . The 1−7 ps components have been assigned to vibrational relaxation in the excited and ground electronic states. In contrast to the dynamics observed in aqueous solutions with the components in the range of 150−500 ps assigned to decay from S 1 to the ground electronic state, these slow components have not been recorded in human breast tissue. We have shown that the lifetimes characterizing the first excited state S 1 in the interfacial regions of the breast tissue are markedly shorter than those in solution. It suggests that molecular structures responsible for harvesting of the light energy in biological tissue find their own ways for recovery through some special features of the potential energy surfaces such as conical intersections, which facilitate the rate of radiationless transitions. We found that the dynamics of photosensitizers in normal (noncancerous) breast tissue is markedly faster than that in cancerous tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

et al. 2013

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“…Until now, several photosensitizers have been applied in veterinary oncology, including porfimer sodium [78][79][80][81][82], phthalocyanines [83,84], and 5-ALA [85][86][87], among others. The use of third-generation approaches was also reported [18].…”

Section: Pdt In Veterinary Oncologymentioning

confidence: 99%

“…Squamous cell carcinoma lesions in 15 cats were followed up three months after CASPcbased PDT. 3/15 cats had no response, 2/15 cats had a partial response (50% reduction), 10/15 cats had a complete response, and 2/15 cats had a recurrence following a complete initial response [83]. CASPc activated by 100 and 200 J/cm 2 was used to determine whether an increase in fluency would improve the advanced squamous cell carcinoma remission period.…”

Section: Carcinomasmentioning

confidence: 99%

“…CASPc-based PDT was administered to three dogs with fibrosarcoma and four with hemangiopericytoma. Of the three animals with fibrosarcoma, one had no response, one had recurrence after nine months, and the other had regional metastasis in 15 months and a relapse after 18 months of treatment [83]. In the case of the hemangiopericytoma patients, the masses were surgically excised, and PDT was performed seven days later.…”

Section: Sarcomasmentioning

confidence: 99%

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Oncological Applications of Photodynamic Therapy in Dogs and Cats

et al. 2022

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Photodynamic therapy (PDT) in small animals’ oncology has been under research focus, pointing to new treatment possibilities. Moreover, several animal studies constitute experimental human disease models due to the similarity of tumor biology between animals and man. PDT uses photosensitizing compounds without toxicity per se. When subjected to a specific wavelength, the photosensitizers are activated, triggering the production of reactive oxygen species (ROS) that lead to cell death. Additionally, antiangiogenic effects and immune stimulation may also be elicited. PDT is minimally invasive, non-toxic, and does not induce carcinogenic or mutagenic side effects. Thus, it is safe for non-neoplastic tissues compared with other neoplasms treatment modalities. This review describes the applications of PDT in the cancer treatment of small animals, particularly dogs and cats, focusing on the respective photosensitizers and treatment protocols used in trials in this therapeutic modality.

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Photostability of biological systems—Femtosecond dynamics of zinc tetrasulfonated phthalocyanine at cancerous and noncancerous human Breast tissues

Abramczyk

Brożek-Płuska

Surmacki

et al. 2017

Journal of Photochemistry and Photobiology A: Chemistry

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Zinc tetrasulfonated phthalocyanine (ZnPcS 4), was studied in aqueous solutions, films and at the biological interfaces of noncancerous and cancerous human breast tissues by using steady state and time resolved spectroscopy methods, including IR, Raman, UV vis, fluorescence and transient absorption femtosecond pump probe spectroscopy. The pump probe transient absorption spectra were recorded on time scales from femtoseconds to nanoseconds providing insight into the molecular mechanisms of energy dissipation and primary events occurring in solution, film, and at the interface of the biological tissues. The nature of the rapid processes and competing relaxation pathways resulting from the initially excited electronic states of ZnPcS 4 in aqueous solutions, films and at the biological interfaces of cancerous and noncancerous human breast tissues was studied. The results provide evidence that the sulfonated zinc phthalocyanine dissipates energy through different pathways in the environment of the noncancerous tissue and of the cancerous tissue. A detailed understanding of the paths of energy dissipation will reveal the mechanisms underlying light induced signal transduction and the role of photoreceptors in photostability of living cells. Here, we showed that both the dynamics of the ground state S 0 recovery and the dynamics of the first excited state S 1 decay at the interfacial regions of the noncancerous tissue is markedly faster than that in the cancerous tissue, suggesting that the molecular mechanisms responsible for harvesting the light energy in photosensitizers can be used for practical applications in cancer diagnostics. The paper bridges the fundamentals of cancer research with the femtosecond technologies of high temporal resolution for studying dynamics of photosensitizers in noncancerous and cancerous human breast tissues.

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Use of chloro-aluminum sulfonated phthalocyanine as a photosensitizer in the treatment of malignant tumors in dogs and cats

Cited by 5 publications

References 0 publications

Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

Oncological Applications of Photodynamic Therapy in Dogs and Cats

Photostability of biological systems—Femtosecond dynamics of zinc tetrasulfonated phthalocyanine at cancerous and noncancerous human Breast tissues

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