Use of CereportTM (RMP-7) to Increase Delivery of Carboplatin to Gliomas: Insight and Parameters for Intracarotid Infusion Via a Single-Lumen Cannula

Bartus, Raymond T.; Snodgrass, Pamela; Dean, Reginald L.; Kim, Byong Su; Black, Keith L.; Emerich, Dwaine F.

doi:10.1080/107175499267110

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…RMP-7 penetrates the BTB by activating B2 receptors on endothelial cells ( 60 ), which seems to be regulated by the NO-cyclic GMP pathway ( 123 , 124 ). Infusion of RMP-7 also enhances intra-arterial delivery of a therapeutic herpes simplex virus vector ( 64 , 125 ) and tumor uptake of carboplatin ( 61 , 126 ). Short-chain alkylglycerols promote delivery of methotrexate ( 68 ) ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review

2020

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Conventional treatments for brain tumors relying on surgery, radiation, and systemic chemotherapy are often associated with high recurrence and poor prognosis. In recent decades, intra-arterial administration of anti-cancer drugs has been considered a suitable alternative drug delivery route to intravenous and oral administration. Intra-arterial administration is believed to offer increasing drug responses by primary and metastatic brain tumors, and to be associated with better median overall survival. By directly injecting therapeutic agents into carotid or vertebral artery, intra-arterial administration rapidly increases intra-tumoral drug concentration but lowers systemic exposure. However, unexpected vascular or neural toxicity has questioned the therapeutic safety of intra-arterial drug administration and limits its widespread clinical application. Therefore, improving targeting and accuracy of intra-arterial administration has become a major research focus. This systematic review categorizes strategies for optimizing intra-arterial administration into five categories: (1) transient blood-brain barrier (BBB)/blood-tumor barrier (BTB) disruption, (2) regional cerebral hypoperfusion for peritumoral hemodynamic changes, (3) superselective endovascular intervention, (4) high-resolution imaging techniques, and (5) others such as cell and gene therapy. We summarize and discuss both preclinical and clinical research, focusing on advantages and disadvantages of different treatment strategies for a variety of cerebral tumor types.

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Section: Resultsmentioning

confidence: 99%

Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review

2020

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“…Fortunately, it was demonstrated that internal carotid artery (ICA) infusion of low doses of a BK agonist selectively and transiently caused breakdown of the BBTB . Coinfusion of GNPs and RI‐BK concurrently would, therefore, provide the simplest, most rational approach because there would be no significant difference in drug delivery efficacy between this and other combined dosing regimens . We then chose the rat C6 glioma model to investigate the size dependence of the enhanced BBTB permeability induced by RI‐BK.…”

Section: Resultsmentioning

confidence: 99%

Effect of Retro‐Inverso Isomer of Bradykinin on Size‐Dependent Penetration of Blood–Brain Tumor Barrier

Wang

Xie

et al. 2018

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Retro-inverso bradykinin (RI-BK) has better metabolic stability and higher affinity for the BK type 2 (B2) receptor, compared with bradykinin. At low doses, RI-BK can selectively enhance the permeability of the blood-brain tumor barrier (BBTB) without harming normal brain tissue. In this study, gold nanoparticles (GNPs) of size ranging from 5 to 90 nm are synthesized to assess the optimal size of nanocarriers that achieves maximum brain accumulation after the treatment of RI-BK. The ability of the GNPs to cross the BBTB is tested in a rat C6 glioma tumor model. The results of inductively coupled plasma-mass spectrometry and transmission electron microscopy indicate that GNPs with size of 70 nm achieve maximum permeability to the glioma. The present study supports the conclusion that RI-BK can enhance the permeability of BBTB and provides fundamental information for further development of nanomedicines or nanoprobes for glioma therapy.

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Translating the therapeutic potential of neurotrophic factors to clinical ‘proof of concept’: A personal saga achieving a career-long quest

Bartus¹

2012

Neurobiology of Disease

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Use of CereportTM (RMP-7) to Increase Delivery of Carboplatin to Gliomas: Insight and Parameters for Intracarotid Infusion Via a Single-Lumen Cannula

Cited by 9 publications

References 17 publications

Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review

Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review

Effect of Retro‐Inverso Isomer of Bradykinin on Size‐Dependent Penetration of Blood–Brain Tumor Barrier

Translating the therapeutic potential of neurotrophic factors to clinical ‘proof of concept’: A personal saga achieving a career-long quest

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